Results 71 to 80 of about 229,983 (244)

Could Cells from Your Nose Fix Your Heart? Transplantation of Olfactory Stem Cells in a Rat Model of Cardiac Infarction

The Scientific World Journal, 2010
This study examines the hypothesis that multipotent olfactory mucosal stem cells could provide a basis for the development of autologous cell transplant therapy for the treatment of heart attack.
Cameron McDonald, Alan Mackay-Sim, Denis Crane, Wayne Murrell   +3 more
doaj   +1 more source

Towards a truly biomimetic olfactory microsystem: an artificial olfactory mucosa

IET Seminar on MEMS Sensors and Actuators, 2006
Today, the capability of the human olfactory system is still, in many ways, superior to that of the electronic nose. Although electronic noses are often compared with their biological counterpart, they neither mimic its neural architecture nor achieve its discriminating performance.
Covington, JA, Gardner, JW, Tan, SL, Hamilton, A, Pearce, TC   +4 more
openaire   +4 more sources

Overcoming intranasal delivery barriers with ultrastable polyzwitterionic siRNA nanocages for enhanced glioblastoma therapy

BMEMat, EarlyView.
A ROS‐responsive, zwitterionic nanocage enables stable, intranasal siRNA delivery to glioblastoma, promoting deep tumor penetration via non‐degradative pathways and trigeminal nerve transport. This platform achieves durable gene silencing and tumor suppression, offering a non‐invasive, storage‐stable strategy for treating glioma and other neurological ...
Jingwen Xie, Jingxing Si, Xiaobei Deng, Jing Tan, Ruijie Zhu, Jizhou Qi, Gaoxia Ma, Bin Wang, Yi Wang, Yunzhou Guo, Yuping Chen, Shiqun Shao, Youqing Shen   +12 more
wiley   +1 more source

Isolation and characterization of olfactory stem cells from canine olfactory mucosa [PDF]

, 2016
Olfactory stem cells have great potential in the treatment of neurodegenerative diseases and they are good candidates for cell therapy due to the easy accessibility of olfactory mucosa.
YAPRAKÇI MV, Celik, Sefa, Yaprakci, Mustafa Volkan, Altunbas, Korhan, ÇELİK S, ALTUNBAŞ K   +5 more
core   +1 more source

Study on the mechanism of electroacupuncture in improving olfactory function in rats with allergic rhinitis-induced olfactory dysfunction through inhibition of inflammatory response

针刺研究
ObjectiveTo observe the effects of electroacupuncture （EA） on olfactory function， olfactory epithelial cell apoptosis， olfactory marker protein （OMP）， cysteinyl aspartate-specific protease-3 （Caspase-3）， and the expression of inflammatory factors in rats
ZHOU Ke-an, WANG Yu-jia, ZHOU Yu-ling, LU Xiao-xiao, ZHANG Qian, HOU Xun-rui, LI Li-hong   +6 more
doaj   +2 more sources

Functional evidence of multidrug resistance transporters (MDR) in rodent olfactory epithelium.

PLoS ONE, 2012
BackgroundP-glycoprotein (Pgp) and multidrug resistance-associated protein (MRP1) are membrane transporter proteins which function as efflux pumps at cell membranes and are considered to exert a protective function against the entry of xenobiotics. While
Adrien Molinas, Gilles Sicard, Ingrid Jakob   +2 more
doaj   +1 more source

Engineering mRNA‐LNP Medicines for the Ageing Brain: Opportunities and Challenges for Neurodegenerative Diseases

Exploration, EarlyView.
This review highlights recent advances in engineering messenger RNA (mRNA)‐lipid nanoparticles (LNPs) to cross the ageing blood–brain barrier and target neurodegenerative diseases. It outlines design principles, delivery routes, and translational challenges, charting a roadmap towards clinical application of mRNA‐LNP therapeutics for neurodegenerative ...
Abdel Ali Belaidi, Denzil L. Furtado, Francesca Alves, Rebecca M. Nisbet, Scott Ayton, Ashley I. Bush   +5 more
wiley   +1 more source

Applying a new version of the Brazilian-Portuguese UPSIT smell test in Brazil [PDF]

, 2010
Standardized olfactory tests are now available to quantitatively assess disorders of olfaction. A Brazilian-Portuguese version of the University of Pennsylvania Smell Identification Test (UPSIT) is currently being developed specifically for the Brazilian
Silveira-Moriyama, L, Azevedo, AMS, Lees, AJ, Ranvaud, R, Barbosa, ER, Doty, RL   +5 more
core  

Acupuncture Alleviates Allergic Rhinitis by Activating the AMPK/PGC‐1α Pathway to Attenuate Mitochondrial Oxidative Stress and Restore Epithelial Barrier Function

Flavour and Fragrance Journal, EarlyView.
Acupuncture at Feishu (BL13), Shenshu (BL23), Yingxiang (LI20), and Dazhui (GV14) alleviates allergic rhinitis by activating the AMPK/PGC‐1α/NRF1/TFAM signalling axis. This activation improves mitochondrial biogenesis and function, reduces mtROS‐mediated oxidative stress, restores ATP production and respiratory complex I/IV activity, suppresses IgE and
Fengying Zhang, Wei Meng, Renzhong Wang, Huijun Du   +3 more
wiley   +1 more source

Engineered 3D cultured human nasal mucosa mesenchymal stem cell derived sEVs for targeted brain‐derived neurotrophic factor delivery to enhance neurogenesis and attenuate brain damage

Interdisciplinary Medicine, EarlyView.
This study successfully developed and evaluated BDNF@RVG‐sEVs, a novel brain‐targeted nanomedicine based on hnmMSC‐derived sEVs, designed to overcome the BBB and enhance neurorestoration. By integrating RVG for enhanced brain targeting and encapsulating BDNF for potent neurorepair, our system address the key limitations of the conventional sEVs and ...
Xueting Wang, Junge Chen, Jiao Xia, Weitong Yang, Teng Ma, Tianzi Shan, Weifeng He, Gaoman Zhang, Zhuoran Xia, Weiwei Wang, Zhusheng Liu, Zhiqiang Yi, Piye Niu, Tian Chen   +13 more
wiley   +1 more source