Results 161 to 170 of about 45,601 (262)

TRP canonical 4 and/or 5 channel inhibition reduces aversion‐ and increases reward‐responding in chronically stressed mice

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Pharmacological inhibition of TRPC4 and/or TRPC5 channels reduces Pavlovian aversion memory in stressed mice and reduces amygdala reactivity to aversion in humans with depression. The aims of this mouse study were to improve understanding of these anxiolytic processes, determine whether there are corrective effects on ...
Giulia Poggi   +14 more
wiley   +1 more source

Matsupexole: A novel nonergot dopamine receptor agonist with sustained efficacy in a rat model of Parkinson's disease and limited off‐target activity

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Dopamine receptor agonists, particularly targeting the dopamine D2L receptor (D2LR), have been used to treat Parkinson's disease (PD). However, valvular heart disease and somnolence, mainly caused by activating the serotonin 5‐HT2B receptor (5‐HT2BR) and dopamine D3 receptor (D3R), respectively, currently challenge their clinical
Takayuki Suzuki   +4 more
wiley   +1 more source

Frontolateral transfalcine approach to olfactory groove meningioma: rationale for surgical selection. Two-dimensional video. [PDF]

open access: yesNeurosurg Focus Video
Burgos-Sosa E   +6 more
europepmc   +1 more source

Expanding the Phenotypic Spectrum Associated With Loss‐of‐Function SMARCA4 Variants to Eye Developmental Anomalies

open access: yesClinical Genetics, EarlyView.
This study expands the clinical spectrum of SMARCA4 by describing a novel phenotype in three unrelated individuals with truncating variants. Distinct from Coffin–Siris syndrome and rhabdoid tumor predisposition, this new association is characterized by ocular malformations, specifically microphthalmia and coloboma.
Bertrand Chesneau   +7 more
wiley   +1 more source

Investigating the Effect of Tumour Necrosis Factor Antagonist on Olfaction

open access: yesClinical Otolaryngology, EarlyView.
ABSTRACT Objectives Tumour Necrosis factor antagonists is a potent anti‐inflammatory medication and has shown to improve olfactory function in murine models. The primary aim was to determine the effect of TNF antagonists on olfactory performance in humans.
Andreas Espehana   +7 more
wiley   +1 more source

A New Experimental Setup to Study the Olfactory Behaviour of Trichogramma Egg Parasitoids

open access: yesEntomologia Experimentalis et Applicata, EarlyView.
We developed an experimental setup to assess odor‐induced egg‐laying behavior in tiny egg‐parasitoid wasps. This Y‐shaped olfactometer, coupled with an AI‐based image‐recognition model, automatically quantifies egg parasitism by Trichogramma wasps. Olfactory‐driven egg‐laying preferences were analyzed using Bayesian inference.
Cécile Bresch, Louise van Oudenhove
wiley   +1 more source

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