Foxg1 and Retinoic Acid Signaling Regulate Zonal Patterning in the Developing Olfactory Epithelium
ABSTRACT Odor information processing begins in the olfactory epithelium (OE), which in mice is spatially divided into two zones: the dorsomedial zone (D‐zone), responsible for innate aversive behaviors, and the ventrolateral zone (V‐zone), associated with learning‐dependent behaviors.
Anzu Kuriyama, Carina Hanashima
wiley +1 more source
Shared Lineage, Distinct Outcomes: Yap and Taz Loss Differentially Impact Schwann and Olfactory Ensheathing Cell Development Without Disrupting GnRH-1 Migration. [PDF]
Taroc EZM+7 more
europepmc +1 more source
Abstract Antenatal destructive events affecting the central nervous system of the foetus lead to disruptive brain lesions that are often associated with impaired neurodevelopment. The pathogenesis of these lesions encompasses a range of causes, including haemorrhagic, embolic, or other vascular events; exposure to teratogens, such as drugs or substance
Ana Alarcón+33 more
wiley +1 more source
Spatiotemporal regulation by downstream genes of <i>Prok2</i> in the olfactory system: from development to function. [PDF]
Kim BR, Rha MS, Cho HJ, Yoon JH, Kim CH.
europepmc +1 more source
Abstract Objective Autoimmune encephalitis (AE) is characterized by inflammatory processes in the central nervous system and frequently presents with seizures. Even though an ictogenic potential has been shown for some antibodies against neuronal surface antigens (NSAbs), AE pathophysiology is complex, and NSAbs‐independent mechanisms are likely to ...
Sara Prevosti+14 more
wiley +1 more source
IL-6 and Olfactory Dysfunction: Focus on Changes, Effects, and Mechanisms. [PDF]
Song XY+8 more
europepmc +1 more source
Type I interferon signalling and interferon‐responsive microglia in health and disease
Recent insights reveal that type I interferon (IFN‐I) signalling plays critical roles in the nervous system beyond antiviral defence. Dysregulated IFN‐I activity is increasingly linked to neurological dysfunction and neurodegeneration, with microglia as central mediators. This review explores the broader impact of IFN‐I signalling on the nervous system
Jose P. Lopez‐Atalaya+1 more
wiley +1 more source
Stem cell CNTF promotes olfactory epithelial neuroregeneration and functional recovery following injury. [PDF]
Cox D+6 more
europepmc +1 more source
A guide to heat shock factors as multifunctional transcriptional regulators
The heat shock factors (HSFs) are evolutionarily conserved transcription factors best known as regulators of molecular chaperone genes in response to heat shock and other protein‐damaging stresses. Vertebrate HSFs, HSF1‐5, HSFX, and HSFY, are implicated in various physiological and pathological processes, including organismal development and cancer ...
Hendrik S. E. Hästbacka+3 more
wiley +1 more source
Olfactory schwannoma in an adolescent: a case report. [PDF]
de Sousa R+10 more
europepmc +1 more source