Results 191 to 200 of about 1,599,645 (340)

Engineered 3D cultured human nasal mucosa mesenchymal stem cell derived sEVs for targeted brain‐derived neurotrophic factor delivery to enhance neurogenesis and attenuate brain damage

open access: yesInterdisciplinary Medicine, EarlyView.
This study successfully developed and evaluated BDNF@RVG‐sEVs, a novel brain‐targeted nanomedicine based on hnmMSC‐derived sEVs, designed to overcome the BBB and enhance neurorestoration. By integrating RVG for enhanced brain targeting and encapsulating BDNF for potent neurorepair, our system address the key limitations of the conventional sEVs and ...
Xueting Wang   +13 more
wiley   +1 more source

Olfactory combinatorial coding supports risk-reward decision-making in <i>Caenorhabditis elegans</i>. [PDF]

open access: yesElife
Hossain Saad MZ   +10 more
europepmc   +1 more source

Limbic Structural Alterations and Structural Covariance Across Prodromal Phenotypes and Early Parkinson's Disease

open access: yesJournal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Non‐motor symptoms may precede motor diagnosis in Parkinson's disease (PD), but whether distinct prodromal phenotypes exhibit differential limbic structural alterations remains unclear. Purpose To investigate limbic structural alterations across prodromal PD phenotypes defined by rapid eye movement sleep behavior disorder (RBD) and ...
Yuanyuan Zhao   +6 more
wiley   +1 more source

Health risk assessment of heavy metal accumulation in fruits exposed to geothermal waters: a case study and global implications

open access: yesJournal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND The present study investigated the potential health risks of heavy metals (HMs) in the fruits and leaves of mulberry and sour cherry trees exposed to water from Sivas geothermal basin (Turkey). RESULTS The target HMs were ranked according to their hazard index as: Cd < Pb < Zn < Cu < Ni < Mn < Cr. The total hazard index for mulberry
E Işıl Arslan Topal   +3 more
wiley   +1 more source

Effect of myrtle aromatization on chemical profile, sensory perception, and bioactivity of white wine vinegar

open access: yesJournal of the Science of Food and Agriculture, EarlyView.
Abstract Background Vinegar is a popular sour condiment rich in nutrients and bioactive components. Individual sour responsiveness greatly affects vinegar acceptance and diet consumption. In this study, the effect of aromatization with myrtle (Myrtus communis), a health‐beneficial Mediterranean aromatic plant, on the chemical composition, sensory ...
Antonella Rosa   +4 more
wiley   +1 more source

Orbital Lymphatic Malformations Are Associated With Intracranial Vascular Anomalies

open access: yesThe Laryngoscope, EarlyView.
In this retrospective series, all seven patients with orbital lymphatic malformations had intracranial vascular anomalies consistent with cerebrofacial venous metameric syndrome and hotspot PIK3CA variants identified through tissue‐based sequencing. Five patients treated with alpelisib experienced symptom improvement within 6 months.
Kelsey A. Loy   +11 more
wiley   +1 more source

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