Results 221 to 230 of about 134,738 (304)

Progress, critical challenges, and translational prospects of intranasal administration of botanical essential oils for the treatment of depression. [PDF]

Front Pharmacol
Cheng K, Zhao H, He K, Xia X, Wang Y, Wang S, Li W.   +6 more
europepmc   +1 more source

Microglial Activation Under Hypoxic Conditions in Early Alzheimer's Disease: Can Natural SIRT1 Activators Be Therapeutic Allies in the Inflammation–Energy Axis?

Phytotherapy Research, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a progressive neurodegenerative condition characterized by a preclinical stage that typically lasts for decades. Early on during this time, microglia react to pathological changes and become protective and even transiently delay neurodegeneration.
Sara Merlo, Cristiana Lucia Rita Lipari, Aurora Patti, Maria Angela Sortino   +3 more
wiley   +1 more source

Intranasal drug delivery: Unlocking the nose-to-brain route for central nervous system therapies. [PDF]

Int J Pharm X
Alwali B, Parumasivam T, Al-Tabakha MM.
europepmc   +1 more source

Can Reprogramming Taste Modulate Excess Food Intake?

Obesity, EarlyView.
Kerstin Rohde‐Zimmermann, Matthias Blüher   +1 more
wiley   +1 more source

Noise‐Induced Hearing Loss: From Pathological Mechanisms to Therapeutic Interventions

Sensory Neuroscience, EarlyView.
ABSTRACT Noise‐induced hearing loss (NIHL), a significant non‐genetic form of hearing impairment, is primarily managed through the use of hearing aids and cochlear implants. However, the fundamental pathological mechanisms underlying NIHL remain inadequately addressed.
Shiqi Huang, Yu Xiao, Jiaxin Liu, Wen Jiang, Weiwei Shi, Hanbing Zhang, Xiaolong Fu, Yunhao Wu   +7 more
wiley   +1 more source

Neuroimaging and Transcriptomic Insights Into Iron Accumulation and Glymphatic Dysfunction in Olfactory Dysfunction. [PDF]

CNS Neurosci Ther
Leong C, Luan J, Wang R, Xu M, Yu H, Zhu L, Shu N, Ouyang G, Xia H, Ma G, Yuan Z.   +10 more
europepmc   +1 more source

GatorST: A Versatile Contrastive Meta‐Learning Framework for Spatial Transcriptomic Data Analysis

Small Methods, EarlyView.
GatorST learns spatially informed embeddings for spatial transcriptomics by coupling two‐hop subgraph graph convolutions with cluster‐aware pseudo‐label supervision and episodic contrastive meta‐learning. The framework captures neighbor‐level topology and tissue‐wide expression semantics without heavy augmentations, delivering robust representations ...
Zhenhao Zhang, Yuxi Liu, Song Wang, Qin Ma, Qianqian Song, Jiang Bian   +5 more
wiley   +1 more source

Integrated stress response genes as novel biomarkers and therapeutic targets in ankylosing spondylitis: a transcriptomic and Mendelian randomization study. [PDF]

Front Immunol
Wang S, Zhu J, Zhang H, Hu S, Mei J, Zhou C, Shi B.   +6 more
europepmc   +1 more source

Information Dynamics and Learning in Complex Adaptive Systems: Toward a Transdisciplinary Framework

Systems Research and Behavioral Science, EarlyView.
ABSTRACT This article develops a framework for understanding learning and adaptation in complex adaptive systems. Drawing from neuroscience, systems theory, information theory and quantum field theory, it examines how information processing, plasticity and systemic coherence emerge from distributed, nonlinear and feedback‐driven interactions. It argues
Anderson de Souza Sant'Anna
wiley   +1 more source

The Olfactory Origins of Affective Processing: A Neurobiological Synthesis Through the Walla Emotion Model. [PDF]

Life (Basel)
Walla P.
europepmc   +1 more source