Results 81 to 90 of about 133,718 (290)

S3RL: Enhancing Spatial Single‐Cell Transcriptomics With Separable Representation Learning

Advanced Science, EarlyView.
Separable Spatial Representation Learning (S3RL) is introduced to enhance the reconstruction of spatial transcriptomic landscapes by disentangling spatial structure and gene expression semantics. By integrating multimodal inputs with graph‐based representation learning and hyperspherical prototype modeling, S3RL enables high‐fidelity spatial domain ...
Laiyi Fu, Penglei Wang, Gaoyuan Xu, Jitao Lu, Qinke Peng, Danyang Wu, Hequan Sun   +6 more
wiley   +1 more source

Beyond anosmia: olfactory dysfunction as a common denominator in neurodegenerative and neurodevelopmental disorders

Frontiers in Neuroscience
Olfactory dysfunction has emerged as a hallmark feature shared among several neurological conditions, including both neurodevelopmental and neurodegenerative disorders.
Yu-Nan Chen, Johanna Katharina Kostka
doaj   +1 more source

Effect of acute copper sulfate exposure on olfactory responses to amino acids and pheromones in goldfish (Carassius auratus) [PDF]

, 2009
Exposure of olfactory epithelium to environmentally relevant concentrations of copper disrupts olfaction in fish. To examine the dynamics of recovery at both functional and morphological levels after acute copper exposure, unilateral exposure of ...
Baldwin D. H., Beyers D. W., Boulay N., Carreau N. D., Chen T. G., De Boeck G., De Boeck G., Dittman A., Evans R. E., Gao X. L., Graziadei G. A., Hansen A., Hansen A., Hansen J. A., Hansen J. A., Hara T. J., Hubbard P. C., Hubbard P. C., Jennings R. A., Julliard A. K., Julliard A. K., Julliard A. K., Keller J. N., Kolmakov N. N., Konzelmann S., Kotrschal K., Mangos S., Masukawa L. M., McIntyre J. K., Moran D. T., Nair A. V., Nikonov A. A., Niyogi S., Pyle G. G., Rolen S. H., Saglio P., Sandahl J. F., Sandahl J. F., Sandahl J. F., Sato Y., Saucier D., Sloman K. A., Sorensen P., Sorensen P. W., Sorensen P. W., Stacey N., Starcevic S. L., Susankova K., Tilton F., Wang R. T., Winberg S., Zippel H. P., Zippel H. P.   +52 more
core   +2 more sources

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Hendra and Nipah Virus Infection in Cultured Human Olfactory Epithelial Cells

mSphere, 2017
Henipaviruses are emerging zoonotic viruses and causative agents of encephalitis in humans. However, the mechanisms of entry into the central nervous system (CNS) in humans are not known.
Viktoriya Borisevich, Mehmet Hakan Ozdener, Bilal Malik, Barry Rockx   +3 more
doaj   +1 more source

Subpopulations of Projection Neurons in the Olfactory Bulb

Frontiers in Neural Circuits, 2020
Generation of neuronal diversity is a biological strategy widely used in the brain to process complex information. The olfactory bulb is the first relay station of olfactory information in the vertebrate central nervous system.
Fumiaki Imamura, Ayako Ito, Brandon J. LaFever   +2 more
doaj   +1 more source

The neuroanatomical organization of projection neurons associated with different olfactory bulb pathways in the sea lamprey, Petromyzon marinus. [PDF]

PLoS ONE, 2013
Although there is abundant evidence for segregated processing in the olfactory system across vertebrate taxa, the spatial relationship between the second order projection neurons (PNs) of olfactory subsystems connecting sensory input to higher brain ...
Warren W Green, Alfred Basilious, Réjean Dubuc, Barbara S Zielinski   +3 more
doaj   +1 more source

Expanding the spectrum of impulse control disorders in Parkinson's disease: the phenomenology of sweet craving [PDF]

, 2013
Thesis (M.A.)--Boston UniversityBackground: The recognized spectrum of impulse control disorders in Parkinson’s disease (PD) includes pathologic gambling, hypersexuality, compulsive buying, and binge eating, and is commonly related to exposure to ...
Brown, Caitlin Harrington
core   +1 more source

Rapid evolution of chemosensory receptor genes in a pair of sibling species of orchid bees (Apidae: Euglossini). [PDF]

, 2015
BackgroundInsects rely more on chemical signals (semiochemicals) than on any other sensory modality to find, identify, and choose mates. In most insects, pheromone production is typically regulated through biosynthetic pathways, whereas pheromone sensory
Brand, Philipp, Eltz, Thomas, Leese, Florian, Quezada-Euan, J Javier G, Ramírez, Santiago R, Tollrian, Ralph   +5 more
core   +3 more sources

Multimodal interactions in insect navigation [PDF]

, 2020
Animals travelling through the world receive input from multiple sensory modalities that could be important for the guidance of their journeys. Given the availability of a rich array of cues, from idiothetic information to input from sky compasses and ...
Buehlmann, Cornelia, Graham, Paul, Mangan, Michael   +2 more
core   +2 more sources