Results 101 to 110 of about 73,571 (348)

Multi‐Omics Profiling Reveals Immunomodulatory and Pro‐Regenerative Effects of a Graphene Oxide–Collagen Scaffold in Massive Rotator Cuff Tears

Advanced Science, EarlyView.
A graphene oxide/collagen scaffold is developed for chronic massive rotator cuff tear repair. The scaffold improves compressive stability, supports reparative mesenchymal differentiation, and modulates the immune microenvironment. In chronic MRCT models, it reduces muscle degeneration, enhances tendon–bone regeneration, and improves functional recovery,
Renwen Wan, Yechuan Deng, Zixin Hu, Yanwei He, Xinting Feng, Jun Ma, Yisheng Chen, Zhijie Zhao, Jie Mei, Zhiheng Lin, Wei Luo, Zhengyuan Fang, Zhufeng Hu, Kunlun Feng, Xinrong Li, Dan Wu, Bowen Han, James Hoi po Hui, Xuanyong Liu, Chen Chen, Gang Chen, Shiyi Chen, Nirong Bao, Jiajun Qiu, Zhiwen Luo   +24 more
wiley   +1 more source

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

An fMRI study on the influence of sommeliers’ expertise on the integration of flavor

Frontiers in Behavioral Neuroscience, 2014
Flavors guide consumers' choice of foodstuffs, preferring those that they like and meet their needs, and dismissing those for which they have a conditioned aversion.
Lionel ePazart, Alexandre eCOMTE, Alexandre eCOMTE, Alexandre eCOMTE, Eloi eMagnin, Eloi eMagnin, Jean-louis eMillot, Thierry eMoulin, Thierry eMoulin, Thierry eMoulin   +9 more
doaj   +1 more source

Spatiotemporal distribution of a late synchronized activity in olfactory pathways following stimulation of the olfactory bulb in rats

, 1998
International audienceThe evoked potential recorded in the rat piriform cortex in response to electrical stimulation of the olfactory bulb is composed of an early component occasionally followed by a late component (60-70 ms).
Mouly, Anne-Marie, Nadine Ravel, Litaudon, Philippe, Ravel, Nadine, Gervais, Rémi, Chabaud, Pascal, Anne‐Marie Mouly, Rémi Gervais, Philippe Litaudon, Pascal Chabaud   +9 more
core   +1 more source

Endogenous Engineering Reprograms Extracellular Vesicles for Enhanced Therapeutic Function

Advanced Science, EarlyView.
This review explains how Extracellular vesicles‐producing cells can be endogenously engineered to load therapeutic proteins and nucleic acids. We summarize physiological and genetic strategies that harness native sorting pathways for selective cargo loading.
Jinghui Wang, Wenxuan Zhao, Xiaoming Hu, Yishu Wang, Peidong Yang, Diwei Zheng, Yugang Wang, Guanghui Ma, Min Shi, Wei Wei, Shuang Wang   +10 more
wiley   +1 more source

Two olfactomotor pathways in lampreys.

, 2018
Schematic representation of the brain illustrating a medial (green) and a lateral (orange) olfactomotor pathways. Both pathways act on the downstream locomotor control circuitry (blue) and thus contribute to olfactory-induced locomotor behaviors in ...
Richard Robitaille (5818880), Felix Clotten (5818871), Elias Atallah (358459), Réjean Dubuc (358471), Gheylen Daghfous (155482), Jean-Luc Létourneau (5818874), Dominique Derjean (358456), François Auclair (358462), Jean-Patrick Millette (5818877), Barbara S. Zielinski (439048)   +9 more
core   +1 more source

Depression and sickness behavior are Janus-faced responses to shared inflammatory pathways [PDF]

, 2012
It is of considerable translational importance whether depression is a form or a consequence of sickness behavior. Sickness behavior is a behavioral complex induced by infections and immune trauma and mediated by pro-inflammatory cytokines.
Anderson, George, Leonard, B, Cai Song, Goehler, Lisa, Gałecki, Piotr, Michael Berk, Michael Maes, Berk, M, Berk, Michael, Maes, Michael, Song, Cai, Leonard, B., Anderson, G, Anderson, G., Leonard, Brian, Maes, M., Piotr Gałecki, Goehler, L., Gałecki, P., Berk, M., Goehler, L, Brian Leonard, Song, C, Gałecki, P, Lisa Goehler, George Anderson, Maes, M, Song, C.   +27 more
core   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

Characterization of the Olfactory Pathway by Anisotropic Diffusion Using Nuclear Magnetic Resonance Imaging in a Pediatric Population [PDF]

, 2019
Ramírez-Flores Héctor, Barragan-Perez Eduardo, D. Pilar, Diana Platas-Neri, Garcia Julio, Hidalgo-Tobón Silvia   +5 more
openalex   +1 more source

Asymmetrical processing of olfactory input in the piriform cortex mediates "activation" of the avian navigation circuitry

, 2016
The role of odors in the long-distance navigation of birds has elicited intense debate for more than half a century. Failure to resolve many of the issues fueling this debate is due at least in part to the absence of controls for a variety of non ...
Pinto, Belmiro V., Phillips, John B., Jorge, Paulo, Marques, Paulo A. M.   +3 more
core   +1 more source