Results 101 to 110 of about 1,599,645 (340)

Up regulated hippocampal insulin pathway and oxidative stress are related to opposite changes in olfaction and episodic memory in a compensatory metabolic syndrome model in rats

Frontiers in Cellular Neuroscience
Insulin resistance, a major component of metabolic syndrome (MetS), is involved in phosphorylated tau and beta amyloid buildup, linking MetS to neurodegenerative processes, e.g., Alzheimer’s disease.
Pedro Isauro Clavel-Pérez, Bryan V. Phillips-Farfán, Luz Camacho-Castillo, Ana Laura Calderón-Garcidueñas, Karla Carvajal   +4 more
doaj   +1 more source

Molecular Atlas of Key Food Odorants Reveals Mixture‐Level Organization and Enables Generative Aroma Design

Advanced Science, EarlyView.
KFO‐Atlas reveals how real‐world aromas are organized as structured mixtures rather than individual molecules. Building on these principles, KFO‐Gen, a generative AI framework, designs perceptually valid aroma formulations and reconstructs meat‐like aromas exclusively from plant‐derived odorants, providing a foundation for mixture‐level studies and AI ...
Jingzhi Zhang, Huadong Xing, Antonella Di Pizio, Qinfei Ke, Xingran Kou, Dachuan Zhang   +5 more
wiley   +1 more source

Mechanisms of pattern processing in olfactory bulb-like circuits [PDF]

, 2010
The scope of brain research spans several orders of magnitude ranging from small groups of amino acid residues in ion channels to fMRI signals reflecting activity averaged over thousands of neurones. From a theoreticians point of view very interesting
Wiechert, Martin Takeo
core   +1 more source

Olfactory-hypoglossal connections

, 2003
Natural olfactory stimulation with amyl acetate significantly modulates the electrical activity of hypoglossal neurons and the electromyographic responses of the tongue musculature.
Melis, Francesco, Caria, Marcello Alessandro, Stanzani, Stefania, Becciu, Chiara Ombretta, Tavera, Claudio, Borke, Rosrmary, Pellitteri, Rosaria, Russo, Antonella, BORKE R, TAVERA C, CARIA M. A, MELIS F, PELLITTERI R, MAMELI O   +13 more
core   +2 more sources

A Real‐Data‐Driven Framework for Evaluating Differential Transcript Usage Methods Across Long‐Read Bulk, Single‐Cell, and Spatial Transcriptomics

Advanced Science, EarlyView.
Grounded in real biological RNA‐seq data, the framework benchmarks ten differential transcript usage (DTU) methods across short‐read bulk, long‐read bulk, long‐read single‐cell, and long‐read spatial transcriptomics. By integrating reference transcript sets with ranked DTU results, the Transcript Set Enrichment Score (TSES) identifies data‐type ...
Chenxing Zhang, Jun Liu, Qi Zhao, Huilong Yin, Angang Yang, Minhua Zheng, Rui Zhang   +6 more
wiley   +1 more source

Neuroinvasion of the 263K scrapie strain after intranasal administration occurs through olfactory-unrelated pathways.

, 2009
The olfactory system has been implicated in the pathogenesis of transmissible spongiform encephalopathies (TSEs). To examine this issue and identify the pattern of TSE agent spread after intranasal administration, we inoculated a high-infectious dose of ...
Cardone F., BENTIVOGLIO FALES, Marina, ZANUSSO, Gianluigi, Valanzano A., De Pascalis A., Pocchiari M., MONACO, Salvatore, Graziano S., Lu M., Ingrosso L., Sbriccoli M.   +10 more
core   +1 more source

Senescence-like cells recruit γδ T cells to drive prolonged hyposmia after SARS-CoV-2 infection in mice

EMBO Reports
Persistent hyposmia is a hallmark of post COVID-19 conditions, yet the mechanisms sustaining olfactory dysfunction after viral clearance remain poorly understood.
Shunya Tsuji, Sosuke Nakano, Koyu Ito, Shohei Minami, Ken Uemura, Yusuke Konishi, Masahiro Wakita, Yumiko Okumura, Shimpei Kawamoto, Akari Matsuki, Shinji Nakaoka, Chikako Ono, Hiroo Takahashi, Itsuki Anzai, Tokiko Watanabe, Akiyoshi Uezumi, Yoshiharu Matsuura, Takeshi Kobayashi, Toru Okamoto, Akio Tsuboi, Masataka Asagiri, Eiji Hara   +21 more
doaj   +1 more source

Astrocytes Coordinate Neurovascular Coupling During Prolonged Sensory Demand via AQP4/TRPA1/BEST1/D‐Serine Signaling

Advanced Science, EarlyView.
Neuronal activation leads to astrocytic transient volume changes, activating transient receptor potential ankyrin 1 (TRPA1) channels, leading to Ca2+ influx. Activation of TRPA1 causes the release of D‐serine through BEST1. Finally, the augmented extracellular levels of D‐serine boost neuronal activity by binding GluN1‐containing NMDARs, leading to CBV
Kayoung Han, Minwoo Wendy Jang, Taeyoung Park, Ki Jung Kim, Victor James Drew, Sunpil Kim, Tai Young Kim, Mingu Gordon Park, Myeongju Kim, Seung Won Chung, Minah Suh, C. Justin Lee   +11 more
wiley   +1 more source

Topological reorganization of odor representations in the olfactory bulb. [PDF]

, 2007
Odors are initially represented in the olfactory bulb (OB) by patterns of sensory input across the array of glomeruli. Although activated glomeruli are often widely distributed, glomeruli responding to stimuli sharing molecular features tend to be ...
Benjamin Judkewitz, Rainer W Friedrich, Judkewitz, Benjamin, Yaksi, E., Yaksi, Emre, Friedrich, Rainer W, Judkewitz, B., Friedrich, R., Emre Yaksi, Friedrich Rainer W, Judkewitz Benjamin, Yaksi Emre   +11 more
core   +2 more sources

Utilization of RNA sequencing to investigate olfactory dysfunction in chronic rhinosinusitis without nasal polyps: A pilot study

World Journal of Otorhinolaryngology-Head and Neck Surgery
Objectives Prior research on olfactory dysfunction in chronic rhinosinusitis (CRS) has focused on patients with polyps and suggests that direct inflammation of the olfactory cleft mucosa plays a contributory role.
Jorge A. Gutierrez III, Jeremy L. Barth, Rodney J. Schlosser, Thomas S. Edwards, Timothy L. Smith, Zachary M. Soler   +5 more
doaj   +1 more source