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2016
The guanine nucleotide protein (G protein)-coupled receptors (GPCRs) superfamily represents the largest class of membrane protein in the human genome. More than a half of all GPCRs are dedicated to interact with odorants and are termed odorant-receptors (ORs).
Gabriela, Antunes +1 more
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The guanine nucleotide protein (G protein)-coupled receptors (GPCRs) superfamily represents the largest class of membrane protein in the human genome. More than a half of all GPCRs are dedicated to interact with odorants and are termed odorant-receptors (ORs).
Gabriela, Antunes +1 more
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Olfactory receptor gene expression
Seminars in Cell & Developmental Biology, 1997Recognition and discrimination of odorous molecules are determined by heptahelical G-protein-coupled receptor proteins localized primarily in the ciliary membrane of olfactory sensory neurons. The discovery of a large multigene family encoding odorant receptors allows us to approach various facets concerning the molecular basis of olfactory ...
H, Breer, J, Strotmann
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Amphibian olfactory receptor neurons express olfactory marker protein
Brain Research, 1992Expression of olfactory marker protein (OMP) in olfactory receptor neurons (ORNs) in two amphibians was investigated by immunohistochemical methods. The OMP immunoreactivity was observed in the cilia, apical dendritic knobs, dendrites and somas of ORNs; the axons of ORNs also showed intense immunoreactivity for OMP throughout their course from the ...
N S, Krishna +3 more
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Genomics of Olfactory Receptors
2009In many species, the sense of smell plays important roles in locating food, detecting predators, navigating, and communicating social information. The olfactory system has evolved complex repertoires of odor receptors (ORs) to fulfill these functions.
Xiaohong, Zhang, Stuart, Firestein
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Olfactory Receptor Interactions with Other Receptors
Annals of the New York Academy of Sciences, 2009Olfactory receptors expressed in heterologous cells often suffer from retention in the endoplasmic reticulum and poor trafficking to the plasma membrane. Interactions of the olfactory receptor M71 with several subtypes of adrenergic and purinergic receptors can alleviate M71 trafficking deficits in heterologous cells and allow for robust M71 plasma ...
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Surface processes of olfactory receptors
Cell and Tissue Research, 1978The free surface morphology of olfactory receptor cells from the nasal mucosa of Cynomolgus monkeys was studied electron microscopically. The receptor cell, in addition to showing characteristic cilia, possess several branched or unbranched shorter elevations or spiny processes covered by numerous delicate lace-like filaments not previously described ...
P, Glees, P E, Spoerri
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Olfactory receptor neurons express D2 dopamine receptors
The Journal of Comparative Neurology, 1999The role of the dopamine (DA) in the olfactory bulb (OB) was explored by determining which of the potential target cells express dopamine receptors (DARs). Previously, it was reported that D2-like DAR (D2, D3, and D4 subtypes) radioligand binding is restricted to the outer layers of the OB.
N L, Koster +6 more
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Evolution of Olfactory Receptors
2013Olfactory receptors are a specialized set of receptor cells responsible for the detection of odors. These cells are G protein-coupled receptors and expressed in the cell membranes of olfactory sensory neurons. Once a cell is activated by a ligand, it initiates a signal transduction cascade that produces a nerve impulse to the brain where odor ...
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1988
The olfactory system displays a dramatically sensitive and selective recognition system for odorants. Animals can detect and discriminate thousands of odorants, some at ambient concentrations as low as one part per trillion (1 ppt). While numerous theories have been advanced to explain this sensitivity and selectivity (Amoore, 1982), remarkably few ...
Solomon H. Snyder +2 more
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The olfactory system displays a dramatically sensitive and selective recognition system for odorants. Animals can detect and discriminate thousands of odorants, some at ambient concentrations as low as one part per trillion (1 ppt). While numerous theories have been advanced to explain this sensitivity and selectivity (Amoore, 1982), remarkably few ...
Solomon H. Snyder +2 more
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Olfactory Receptor Gene Regulation
1998The mammalian olfactory system recognizes and discriminates a vast array of odorant ligands . The number of odors that can be distinguished is on the order of tens of thousands. Recognition is accomplished, initially, by members of a family of 1000 odorant receptors. Thus the olfactory system rivals the immune system in its ability to recognize a large
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