Predicting olfactory receptor neuron responses from odorant structure [PDF]
Chemistry Central Journal, 2007 Background Olfactory receptors work at the interface between the chemical world of volatile molecules and the perception of scent in the brain. Their main purpose is to translate chemical space into information that can be processed by neural circuits ...
Hähnel Melanie +3 more
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High Precision of Spike Timing across Olfactory Receptor Neurons Allows Rapid Odor Coding in Drosophila [PDF]
iScience, 2018 Summary: In recent years, it has become evident that olfaction is a fast sense, and millisecond short differences in stimulus onsets are used by animals to analyze their olfactory environment.
Alexander Egea-Weiss +3 more
doaj +4 more sources
Olfactory Receptor Neuron Dysfunction in Schizophrenia [PDF]
Neuropsychopharmacology, 2008 Olfactory impairments are a common feature of schizophrenia. Impairments in odor detection and odor identification are present early in the course of illness and among those at risk for the disorder. These behavioral impairments have been linked to both physiological and anatomical abnormalities in the neural substrates subserving olfaction, including ...
Bruce I. Turetsky +3 more
openalex +3 more sources
Olfactory deficits in an alpha-synuclein fly model of Parkinson's disease. [PDF]
PLoS ONE, 2014 Parkinson's disease (PD) is the most common motor neurodegenerative disorder. Olfactory dysfunction is a prevalent feature of PD. It often precedes motor symptoms by several years and is used in assisting PD diagnosis. However, the cellular and molecular
Alex Y Chen +3 more
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Inhibition among olfactory receptor neurons [PDF]
Frontiers in Human Neuroscience, 2013 Often assumed to be epiphenomena of a cell’s activity, extracellular currents and resulting potential changes are increasingly recognized to influence the function of other cells in the vicinity.
Wynand eVan der Goes van Naters
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Advantage of the Highly Restricted Odorant Receptor Expression Pattern in Chemosensory Neurons of Drosophila. [PDF]
PLoS ONE, 2013 A fundamental molecular feature of olfactory systems is that individual neurons express only one receptor from a large odorant receptor gene family. While numerous theories have been proposed, the functional significance and evolutionary advantage of ...
Sana Khalid Tharadra +2 more
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The effect of Drosophila attP40 background on the glomerular organization of Or47b olfactory receptor neurons. [PDF]
G3 (Bethesda), 2023 Duan Q +4 more
europepmc +3 more sources
Asymmetric ephaptic inhibition between compartmentalized olfactory receptor neurons. [PDF]
Nat Commun, 2019 ABSTRACTIn the Drosophila antenna, different subtypes of olfactory receptor neurons (ORNs) housed in the same sensory hair (sensillum) can inhibit each other non-synaptically. However, the mechanisms underlying this unusual form of lateral inhibition remain unclear. Here we use recordings from pairs of sensilla impaled by the same tungsten electrode to
Zhang Y +7 more
europepmc +7 more sources
Differential Contributions of Olfactory Receptor Neurons in a Drosophila Olfactory Circuit. [PDF]
eNeuro, 2016 AbstractThe ability of an animal to detect, discriminate, and respond to odors depends on the functions of its olfactory receptor neurons (ORNs). The extent to which each ORN, upon activation, contributes to chemotaxis is not well understood. We hypothesized that strong activation of each ORN elicits a different behavioral response in theDrosophila ...
Newquist G +3 more
europepmc +4 more sources
Prior activity of olfactory receptor neurons is required for proper sensory processing and behavior in Drosophila larvae. [PDF]
Sci Rep, 2018 Utashiro N +3 more
europepmc +3 more sources