Predicting olfactory receptor neuron responses from odorant structure
Chemistry Central Journal, 2007 Background Olfactory receptors work at the interface between the chemical world of volatile molecules and the perception of scent in the brain. Their main purpose is to translate chemical space into information that can be processed by neural circuits ...
Hähnel Melanie +3 more
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Chromatin Modulatory Proteins and Olfactory Receptor Signaling in the Refinement and Maintenance of Fruitless Expression in Olfactory Receptor Neurons. [PDF]
PLoS Biology, 2016 During development, sensory neurons must choose identities that allow them to detect specific signals and connect with appropriate target neurons. Ultimately, these sensory neurons will successfully integrate into appropriate neural circuits to generate ...
Catherine E Hueston +6 more
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High Precision of Spike Timing across Olfactory Receptor Neurons Allows Rapid Odor Coding in Drosophila [PDF]
iScience, 2018 Summary: In recent years, it has become evident that olfaction is a fast sense, and millisecond short differences in stimulus onsets are used by animals to analyze their olfactory environment.
Alexander Egea-Weiss +3 more
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Ir76b is a Co-receptor for Amine Responses in Drosophila Olfactory Neurons
Frontiers in Cellular Neuroscience, 2021 Two large families of olfactory receptors, the Odorant Receptors (ORs) and Ionotropic Receptors (IRs), mediate responses to most odors in the insect olfactory system. Individual odorant binding “tuning” OrX receptors are expressed by olfactory neurons in
Alina Vulpe, Karen Menuz, Karen Menuz
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Neuromodulation of olfactory sensitivity in the peripheral olfactory organs of the American cockroach, Periplaneta americana. [PDF]
PLoS ONE, 2013 Olfactory sensitivity exhibits daily fluctuations. Several studies have suggested that the olfactory system in insects is modulated by both biogenic amines and neuropeptides. However, molecular and neural mechanisms underlying olfactory modulation in the
Je Won Jung +5 more
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Chemoreceptor co-expression in Drosophila melanogaster olfactory neurons
eLife, 2022 Drosophila melanogaster olfactory neurons have long been thought to express only one chemosensory receptor gene family. There are two main olfactory receptor gene families in Drosophila, the odorant receptors (ORs) and the ionotropic receptors (IRs). The
Darya Task +11 more
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Transplant Antennae and Host Brain Interact to Shape Odor Perceptual Space in Male Moths. [PDF]
PLoS ONE, 2016 Behavioral responses to odors rely first upon their accurate detection by peripheral sensory organs followed by subsequent processing within the brain's olfactory system and higher centers. These processes allow the animal to form a unified impression of
Seong-Gyu Lee +3 more
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Frontiers in Ecology and Evolution, 2022 In moths, mate finding relies on female-emitted sex pheromones that the males have to decipher within a complex environmental odorant background. Previous studies have shown that interactions of both sex pheromones and plant volatiles can occur in the ...
Paul Vandroux +6 more
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Cell Reports, 2020 Summary: Olfactory neurons allow animals to discriminate nutritious food sources from potential pathogens. From a forward genetic screen, we uncovered a surprising requirement for the olfactory neuron gene olrn-1 in the regulation of intestinal ...
Kyle J. Foster +5 more
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Olfactory deficits in an alpha-synuclein fly model of Parkinson's disease. [PDF]
PLoS ONE, 2014 Parkinson's disease (PD) is the most common motor neurodegenerative disorder. Olfactory dysfunction is a prevalent feature of PD. It often precedes motor symptoms by several years and is used in assisting PD diagnosis. However, the cellular and molecular
Alex Y Chen +3 more
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