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RNA-mediated symmetry breaking enables singular olfactory receptor choice. [PDF]

open access: yesNature
Pourmorady AD   +13 more
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Olfactory receptors

Cellular and Molecular Life Sciences (CMLS), 2004
Olfaction is an ancient sensory system allowing an organism to detect chemicals in its environment. The first step in odor transduction is mediated by binding odorants to olfactory receptors (ORs) which belong to the heptahelical G-protein-coupled receptor (GPCR) superfamily. Mammalian ORs are disposed in clusters on virtually all chromosomes. They are
Gaillard, Isabelle   +2 more
openaire   +6 more sources

Modeling of Olfactory Receptors

2023
Olfactory receptors (ORs) form the largest subfamily within class A G protein-coupled receptors (GPCRs). No experimental structural data of any OR is available to date. Homology modeling has become a popular strategy to propose plausible OR models, in order to study the structure-function relationships of the receptors and to aid the discovery and ...
Xueying, Wang   +2 more
openaire   +2 more sources

Recent advances in olfactory receptor-basedbiosensors

Biosensors and Bioelectronics, 2013
Liping Du, Chunsheng Wu, Qingjun Liu
exaly   +2 more sources

Olfactory receptor function

2019
Olfaction plays a critical role in several aspects of life. Olfactory disorders are very common in the general population, and can lead to malnutrition, weight loss, food poisoning, depression, and other disturbances. Odorants are first detected in the upper region of the nose by the main olfactory epithelium (OE). In this region, millions of olfactory
Isaías, Glezer, Bettina, Malnic
openaire   +2 more sources

Olfactory receptor signaling

2016
The guanine nucleotide protein (G protein)-coupled receptors (GPCRs) superfamily represents the largest class of membrane protein in the human genome. More than a half of all GPCRs are dedicated to interact with odorants and are termed odorant-receptors (ORs).
Gabriela, Antunes   +1 more
openaire   +2 more sources

Olfactory Receptor Proteins

2014
Bioelectronic noses can utilize olfactory receptors (ORs) as recognition elements. This chapter describes biochemical characteristics of these OR proteins. ORs being G protein-coupled receptors (GPCRs) are integral membrane proteins composed of seven transmembrane spanning helices.
Sanz, Guenhaël   +2 more
openaire   +2 more sources

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