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Genomics of Olfactory Receptors
2009In many species, the sense of smell plays important roles in locating food, detecting predators, navigating, and communicating social information. The olfactory system has evolved complex repertoires of odor receptors (ORs) to fulfill these functions.
Xiaohong, Zhang, Stuart, Firestein
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Olfactory Receptor Interactions with Other Receptors
Annals of the New York Academy of Sciences, 2009Olfactory receptors expressed in heterologous cells often suffer from retention in the endoplasmic reticulum and poor trafficking to the plasma membrane. Interactions of the olfactory receptor M71 with several subtypes of adrenergic and purinergic receptors can alleviate M71 trafficking deficits in heterologous cells and allow for robust M71 plasma ...
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Olfactory receptor gene expression
Seminars in Cell & Developmental Biology, 1997Recognition and discrimination of odorous molecules are determined by heptahelical G-protein-coupled receptor proteins localized primarily in the ciliary membrane of olfactory sensory neurons. The discovery of a large multigene family encoding odorant receptors allows us to approach various facets concerning the molecular basis of olfactory ...
H, Breer, J, Strotmann
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Surface processes of olfactory receptors
Cell and Tissue Research, 1978The free surface morphology of olfactory receptor cells from the nasal mucosa of Cynomolgus monkeys was studied electron microscopically. The receptor cell, in addition to showing characteristic cilia, possess several branched or unbranched shorter elevations or spiny processes covered by numerous delicate lace-like filaments not previously described ...
P, Glees, P E, Spoerri
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Evolution of Olfactory Receptors
2013Olfactory receptors are a specialized set of receptor cells responsible for the detection of odors. These cells are G protein-coupled receptors and expressed in the cell membranes of olfactory sensory neurons. Once a cell is activated by a ligand, it initiates a signal transduction cascade that produces a nerve impulse to the brain where odor ...
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A nanobiosensor based on olfactory receptors
2009 3rd International Workshop on Advances in sensors and Interfaces, 2009We propose an electronic nose of new generation, i.e. a nanosensor based on the use of large biomolecules, olfactory receptors, as sensing material. Modelling, design and experiments performed for proving the concept are reported and discussed.
ALFINITO, ELEONORA +3 more
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Are Olfactory Receptors Really Olfactive?
Biosemiotics, 2011Any living organism interacts with and responds specifically to environmental molecules by expressing specific olfactory receptors. This specificity will be first examined in causal terms with particular emphasis on the mechanisms controlling olfactory gene expression, cell-to-cell interactions and odor-decoding processes.
Giorgi F, MAGGIO, Roberto, Bruni LE
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The structure and function of olfactory receptors
Trends in Pharmacological SciencesOlfactory receptors (ORs) form the most important chemosensory receptor family responsible for our sense of smell in the nasal olfactory epithelium. This receptor family belongs to the class A G protein-coupled receptors (GPCRs). Recent research has indicated that ORs are involved in many nonolfactory physiological processes in extranasal tissue, such ...
Chenyang Wu +4 more
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Molecular biology of olfactory receptors
Essays in Biochemistry, 1998OR proteins bind odorant ligands and transmit a G-protein-mediated intracellular signal, resulting in generation of an action potential. The accumulation of DNA sequences of hundreds of OR genes provides an opportunity to predict features related to their structure, function and evolutionary diversification.
Y, Pilpel, A, Sosinsky, D, Lancet
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