Results 91 to 100 of about 102,826 (347)

Odors: from chemical structures to gaseous plumes [PDF]

, 2020
We are immersed within an odorous sea of chemical currents that we parse into individual odors with complex structures. Odors have been posited as determined by the structural relation between the molecules that compose the chemical compounds and their ...
Escalon, James A., Mathew, Dennis, Young, Benjamin D.   +2 more
core  

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Functional olfactory sensory neurons housed in olfactory sensilla on the ovipositor of the hawkmoth Manduca sexta.

Frontiers in Ecology and Evolution, 2016
Olfactory systems evolved to detect and identify volatile chemical cues, in many cases across great distances. However, the precision of copulatory and oviposition behaviors suggest that they may be guided by olfactory cues detected by sensory systems ...
Christian Felix Klinner, Christopher König, Christine Missbach, Achim Werckenthin, Kevin Charles Daly, Sonja Bisch-Knaden, Monika Stengl, Bill S. Hansson, Ewald Große-Wilde   +8 more
doaj   +1 more source

Anosmin-1 modulates fibroblast growth factor receptor 1 signaling in human gonadotropin-releasing hormone olfactory neuroblasts through a heparan sulfate-dependent mechanism [PDF]

, 2004
Defects of either anosmin-1 or fibroblast growth factor receptor 1 (FGFR1) are known to underlie hereditary Kallmann's syndrome (KS), a human disorder of olfactory and gonadotropin-releasing hormone (GnRH) neuronal ontogeny.
Bouloux, PM, Gonzalez-Martinez, D, Guimond, S, Hu, YL, Kim, SH, Schofield, J, Turnbull, J, Vannelli, GB, Winyard, P   +8 more
core   +1 more source

Intracellular Aβ42 Sequestration by a Serine Protease Mitigates Neurotoxicity in a Drosophila Alzheimer's Disease Model

Advanced Science, EarlyView.
Emerging evidence suggests that intraneuronal Aβ accumulation represents an early pathogenic event in Alzheimer's disease (AD). Using Drosophila AD model, this study shows that a nonsecreted serine protease Yip7 physically interacts with Aβ. This causes intraneuronal Aβ accumulation but surprisingly reduces the associated neurotoxicity, arguing that ...
Jingyun Su, Meng Yang, Xinfeng Wang, Pa Wu, Zongzhao Zhai   +4 more
wiley   +1 more source

The activity-dependent histone variant H2BE modulates the life span of olfactory neurons

eLife, 2012
We have identified a replication-independent histone variant, Hist2h2be (referred to herein as H2be), which is expressed exclusively by olfactory chemosensory neurons. Levels of H2BE are heterogeneous among olfactory neurons, but stereotyped according to
Stephen W Santoro, Catherine Dulac
doaj   +1 more source

Aromatase and estrogen receptor beta expression in the rat olfactory bulb: neuroestrogen action in the first relay station of the olfactory pathway? [PDF]

, 2014
The expression pattern of aromatase (ARO), the enzyme converting androgens to estrogens, was analyzed in the olfactory bulb of adult male rats and was compared with the distribution of estrogen receptor beta (ER beta), the main estrogen receptor isoform ...
Csákvári, Eszter, Gyenes, Andrea, Harada, N., Hoyk, Zsófia, Párducz, Árpád, Siklós, László   +5 more
core  

Self-organization in the olfactory system: one shot odor recognition in insects [PDF]

, 2005
We show in a model of spiking neurons that synaptic plasticity in the mushroom bodies in combination with the general fan-in, fan-out properties of the early processing layers of the olfactory system might be sufficient to account for its efficient ...
A Gelperin, A Whitehead, B Cazelles, B Ehmer, B Ermentrout, C Cortes, C Pelz, CD Brody, CG Galizia, DA Wilson, DG Wüstenberg, EC Marin, FT Sommer, G Laurent, G Laurent, G-Q Bi, G-Q Bi, H Ikeno, H Markram, H Zhu, HB Treloar, HDI Abarbanel, Henry D. I. Abarbanel, J Joerges, J Kauer, J Perez-Orive, J White, JS Belle de, JS Hosler, LB Vosshall, M Barth, M Garcia-Sanchez, M Heisenberg, M Stopfer, M Stopfer, M Wehr, Mikhail I. Rabinovich, N Uchida, NF Rulkov, NK Tanaka, O Hendin, P Mombaerts, R Huerta, R Malinov, Ramón Huerta, RC O’Reilly, RD Traub, RW Friedrich, S Sachse, S Sachse, T Cover, T Komiyama, T Nowotny, Thomas Nowotny, W Gerstner, W Gerstner, W Maas, Y Wang, Z Li   +58 more
core   +2 more sources

Biomimetic Ru‐Mn Nanozyme with Cascade Catalytic Activity Attenuates Secondary Brain Injury in Intracerebral Hemorrhage

Advanced Science, EarlyView.
Ru–Mn composite nanozymes are engineered to mimic dual‐enzyme cascade catalysis, enabling efficient ROS clearance and neuroinflammation suppression. In collagenase‐ and autologous blood‐induced ICH mouse models, intranasal and intravenous administration reduced hematoma volume, preserved BBB integrity, and improved neurological recovery.
Zhongxin Duan, Peng Li, Yue Wang, Xin Qi, Wanyu Wang, Yongzhong Cheng, Huabin Zhang, Xin Hu, Xiang Gao   +8 more
wiley   +1 more source

Functional evidence of multidrug resistance transporters (MDR) in rodent olfactory epithelium.

PLoS ONE, 2012
BackgroundP-glycoprotein (Pgp) and multidrug resistance-associated protein (MRP1) are membrane transporter proteins which function as efflux pumps at cell membranes and are considered to exert a protective function against the entry of xenobiotics. While
Adrien Molinas, Gilles Sicard, Ingrid Jakob   +2 more
doaj   +1 more source