Results 91 to 100 of about 260,549 (299)

Sulfakinin Signaling Sense Circulating Fructose and Suppresses Food Consumption via Insulin‐Like Peptide in Bactrocera Dorsalis

Advanced Science, EarlyView.
This study discovered a new pathway that tells fruit flies when to stop eating. It found that rising blood sugar (fructose) is detected by a sensor called GR43a. This triggers a chain reaction involving the satiety signal sulfakinin and its receptor, ultimately activating a final satiety signal, ILP5.
Hong‐Fei Li, Bao Dong, Zheng‐Lin Ren, Xue‐Guang Zhu, Quan Lei, Yoonseong Park, Jin‐Jun Wang, Hong‐Bo Jiang   +7 more
wiley   +1 more source

Olfactory System in Drosophila

Journal of Vasyl Stefanyk Precarpathian National University, 2015
Smell is an ancient sensory system presented virtually in organisms from bacteria tohumans. In Drosophila odors elicit a variety of behavioral responses in relatively simple butsensitive olfactory system. An increasing number of mutants have been found to be defective inolfactory function.
openaire   +3 more sources

Fibronectin1‐Expressing Subicular Circuits Selectively Govern the Retrieval of Novel Object Recognition

Advanced Science, EarlyView.
Fibronectin 1 (FN1)‐expressing subicular subpopulations encode novel object preference and selectively govern retrieval of novel object recognition (NOR) via affecting excitability of entorhinal‐projecting circuit through large conductance Ca2+‐activated potassium (BK) channel. ABSTRACT Novel object recognition (NOR), referring to the cognitive ability
Fan Fei, Jiaying Shi, Jing Xi, Yixiang Xu, Shuye Ying, Xukun Fan, Wangjialu Lu, Zhisheng Li, Menghan Li, Yu Wang, Li Cheng, Lin Yang, Lingyu Xu, Zhong Chen, Cenglin Xu, Yi Wang   +15 more
wiley   +1 more source

Anosmin-1 modulates fibroblast growth factor receptor 1 signaling in human gonadotropin-releasing hormone olfactory neuroblasts through a heparan sulfate-dependent mechanism [PDF]

, 2004
Defects of either anosmin-1 or fibroblast growth factor receptor 1 (FGFR1) are known to underlie hereditary Kallmann's syndrome (KS), a human disorder of olfactory and gonadotropin-releasing hormone (GnRH) neuronal ontogeny.
Bouloux, PM, Gonzalez-Martinez, D, Guimond, S, Hu, YL, Kim, SH, Schofield, J, Turnbull, J, Vannelli, GB, Winyard, P   +8 more
core   +1 more source

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

The unfolded protein response is activated in the olfactory system in Alzheimer’s disease

Acta Neuropathologica Communications, 2020
Olfactory dysfunction is an early and prevalent symptom of Alzheimer’s disease (AD) and the olfactory bulb is a nexus of beta-amyloid plaque and tau neurofibrillary tangle (NFT) pathology during early AD progression.
Helen C. Murray, Birger Victor Dieriks, Molly E. V. Swanson, Praju Vikas Anekal, Clinton Turner, Richard L. M. Faull, Leonardo Belluscio, Alan Koretsky, Maurice A. Curtis   +8 more
doaj   +1 more source

Sensory Measurements: Coordination and Standardization [PDF]

, 2015
Do sensory measurements deserve the label of “measurement”? We argue that they do. They fit with an epistemological view of measurement held in current philosophy of science, and they face the same kinds of epistemological challenges as physical ...
A Ferguson, A Keller, A Majid, A Sorowska, A-S Barwich, Ann-Sophie Barwich, BAAS, C Bushdid, C Darwin, C Sell, CH Hawkes, DA Baylor, DA Deems, DD Stettler, DT Jones, E Barkai, E Tal, E Wnuk, EAM Gamble, FF Chen, GM Shepherd, GM Shepherd, H Chang, H Chang, Hasok Chang, I Tourbier, IJ Deary, J Canales, J Lötsch, J Michell, JH Cho, JY Lettvin, KC Elliott, LB Buck, M Jones-Gotman, M Meister, M Spehr, NE Bowman, PB Sklar, PM Wise, R Axel, RA Frank, RC Gerkin, RL Doty, RL Doty, S Firestein, S Firestein, S Hecht, S Pinker, SA Klein, SS Stevens, SS Stevens, T Hummel, T Hummel, U Pace, W Bechtel, Y Oka   +56 more
core   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Neuropeptide complexity in the crustacean central olfactory pathway: immunolocalization of A-type allatostatins and RFamide-like peptides in the brain of a terrestrial hermit crab

Molecular Brain, 2012
Background In the olfactory system of malacostracan crustaceans, axonal input from olfactory receptor neurons associated with aesthetascs on the animal’s first pair of antennae target primary processing centers in the median brain, the olfactory lobes ...
Polanska Marta A, Tuchina Oksana, Agricola Hans, Hansson Bill S, Harzsch Steffen   +4 more
doaj   +1 more source

Early Olfactory Involvement in Alzheimer's Disease [PDF]

, 2017
Background: In Alzheimer's disease (AD) the olfactory system, including the olfactory bulb, a limbic paleocortex is severely damaged. The occurrence of early olfactory deficits and the presence of senile plaques and neurofibrillary tangles in olfactory ...
Christen-Zaech, S., Khalili, K., Kiraly, M., Kraftsik, R., Martins, R., Miklossy, J., Pillevuit, O.   +6 more
core