Results 121 to 130 of about 699 (156)

I1. A Randomized, Placebo- and Active-Controlled Phase 2b Study Investigating Oliceridine (TRV130)

, 2017
Franck Skobieranda, David Burt, David Soergel, Harold Minkowitz   +3 more
core   +1 more source

Gastrointestinal Tolerability With Oliceridine, A Novel µ Receptor G Protein Pathway Selective (µ-GPS) Modulator [4H]

, 2017
Franck Skobieranda, David Burt, David Soergel, Adam C. Steinberg   +3 more
core   +1 more source

Estimation of ED₅₀ and ED₉₅ of Oliceridine Required to Suppress the Bronchoscopy Response in Patients Undergoing Fiberoptic Bronchoscopy Under Sedation with Cipepofol: An Up-and-Down Sequential Allocation Trial. [PDF]

Drug Des Devel Ther
Wu D, Liao Y, Qin Y, Wang Y, Xu B, Chen Q, Wang X, Wu X, Li Y, Guan X.   +9 more
europepmc   +1 more source

The effects of oliceridine and sufentanil on postoperative nausea and vomiting in abdominal surgery (EOSPONVAS): protocol for a multicentre, two-arm, randomised controlled trial. [PDF]

BMJ Open
Luo J, Wang L, Jie Z, Li Y, Geng C, Li P, Wang T, Shi Y, Fan X, Zhang L, Xu T.   +10 more
europepmc   +1 more source

Comparison of oliceridine and sufentanil in patient - controlled intravenous analgesia for post - thoracoscopic nausea and vomiting: a prospective, double - blind, randomized controlled trial. [PDF]

Front Pharmacol
Meng Y, Yuan S, Zhang H, Ling Z, Shi C, Niu Y, Zhang L, Xu Z, Liu Y, Zhou K, Liu S, Zhao L.   +11 more
europepmc   +1 more source

In Response. [PDF]

Anesth Analg
Cao S, Daniels M, Hah JM, Hao D.
europepmc   +1 more source

Benefit and Risk Evaluation of Biased μ-Receptor Agonist Oliceridine versus Morphine [PDF]

Anesthesiology, 2020
Background To improve understanding of the respiratory behavior of oliceridine, a μ-opioid receptor agonist that selectively engages the G-protein–coupled signaling pathway with reduced activation of the β-arrestin pathway, the authors compared its utility function with that of morphine.
Albert Dahan, Marieke Niesters, Monique Van Velzen   +2 more
exaly   +7 more sources

Pharmacological Advances in Opioid Therapy: A Review of the Role of Oliceridine in Pain Management [PDF]

Pain and Therapy, 2021
Problems with the treatment of acute pain may arise when a patient is opioid-tolerant, such as those on chronic therapy with opioids or opiate replacement therapy, those who misuse opioids, and those who are in recovery. While some of the adverse effects of opioid medications are well known, it is also important to recognize the roles of tolerance and ...
Alan D Kaye, Amber N Edinoff, Elyse M Cornett   +2 more
exaly   +5 more sources

Oliceridine in the Treatment of Moderate to Severe Acute Pain

Pain Management, 2021
Intravenous opioids are a mainstay for the management of moderate to severe acute pain. Opioid administration provides effective pain control at the cost of significant side effects. Commonly used opioids like morphine are nonselective μ-receptor agonists, which stimulate both the G-protein pathway, associated with the analgesic effect, and the β ...

exaly   +4 more sources

Budget impact and pharmacy costs with targeted use of oliceridine for postsurgical pain in patients at high risk of opioid-related adverse events

Expert Review of Pharmacoeconomics and Outcomes Research, 2022
Oliceridine, a new class of μ-opioid receptor agonist, may be associated with fewer opioid-related adverse events (ORAEs) due to its unique mechanism of action.
Kit N Simpson, Michael J Fossler, Linda Wase   +2 more
exaly   +2 more sources