Results 141 to 150 of about 699 (156)

Safety evaluation of oliceridine for the management of postoperative moderate-to-severe acute pain

Expert Opinion on Drug Safety, 2021
Opioids for managing postoperative pain are associated with side effects including opioid-induced respiratory depression (OIRD) and gastrointestinal complications. Opioids induce analgesia via G-protein signaling, while adverse effects are mediated by the β-arrestin pathway.
Hon Sen, Tan, Ashraf S, Habib
openaire   +2 more sources

Evaluating oliceridine as a treatment option for moderate to severe acute post-operative pain in adults

Expert Opinion on Pharmacotherapy, 2021
Despite the advances in regional anesthesia and non-opioid systemic analgesia, opioids remain the primary rescue analgesic for moderate to severe pain. However, the risks and side effects of opioid medications are well documented. Oliceridine is a novel opioid receptor agonist which is thought to have less risk of adverse events, such as postoperative ...
Zhaosheng Jin, Mingxi Zhu, Abhishek Gupta, Christopher Page, Tong J Gan, Sergio D Bergese   +5 more
openaire   +2 more sources

Research Progress on the Safety of Oliceridine in Perioperative Application

Current Research in Medical Sciences
Oliceridine is the first approved biased μ-opioid receptor agonist. It produces analgesia by selectively activating the G protein pathway while minimizing β-arrestin recruitment, a mechanism that theoretically uncouples analgesia from adverse effects. This article systematically reviews the pharmacological basis for the perioperative use of oliceridine,
Tianzhong Jia, Xichun Zhu, Lihui Yue, Yifan Dong, Weizhuang Jia   +4 more
openaire   +1 more source

Efficacy and effectiveness of Oliceridine in acute postoperative pain, a systematic review and meta-analysis

2023
Review question / Objective: Oliceridine is a relatively novel so called bias opioid which is approved for severe opioid requiring pain. Due to its biased agonism, it is said to have fewer side effects than conventional opioids. This systematic review and meta-analysis will analyze the efficacy and effectiveness of oliceridine compared to placebo or ...
Anne WolfvWolf, Matthias Unterberg, Andrea Witowski, Michael Adamzik, Alexander Wolf   +4 more
openaire   +1 more source

Further investigation of the rapid-onset and short-duration action of the G protein-biased μ-ligand oliceridine

Biochemical and Biophysical Research Communications, 2021
Tomohisa Mori, Yoshinori Takemura, Michiko Narita   +2 more
exaly  

Evaluating oliceridine as a treatment option for moderate to severe acute post-operative pain in adults

Expert Opinion on Pharmacotherapy, 2022
Zhaosheng Jin, Sérgio D Bergese
exaly  

The Influence of Renal or Hepatic Impairment on the Pharmacokinetics, Safety, and Tolerability of Oliceridine

Clinical Pharmacology in Drug Development, 2020
Anne N Nafziger, Franck Skobieranda, David A Burt   +2 more
exaly  

Oliceridine Exhibits Improved Tolerability Compared to Morphine at Equianalgesic Conditions: Exploratory Analysis from Two Phase 3 Randomized Placebo and Active Controlled Trials

Pain and Therapy, 2021
Gregory B Hammer, Ashish K Khanna, Linda Wase   +2 more
exaly  

Oliceridine: A Novel I.V. Opioid with a Promising Benefit-Risk Profile

ASA Monitor, 2020
openaire   +1 more source

The Utilization of Mu-Opioid Receptor Biased Agonists: Oliceridine, an Opioid Analgesic with Reduced Adverse Effects

Current Pain and Headache Reports, 2019
Ivan Urits, Omar Viswanath, Vwaire Orhurhu   +2 more
exaly