Results 91 to 100 of about 604 (162)

The cGAS–STING Pathway Drives Astrocyte‐Mediated Demyelination in Multiple Sclerosis Through Clusterin Secretion

CNS Neuroscience &Therapeutics, Volume 32, Issue 8, August 2026.
In multiple sclerosis, astrocytes detect extracellular DNA via the cGAS–STING pathway, triggering Clusterin secretion that induces oligodendrocyte apoptosis and demyelination. Pharmacological STING inhibition with H‐151 suppresses this neurotoxic cascade, preserves myelin integrity, and ameliorates clinical disability in experimental autoimmune ...
Shengfei Hu, Xia Xiao, Xi Cheng, Yiying Huang, Tingting Cui, Shishi Shen, Chunping Cui, Li Xiao, Hanzhang Tan, Wei Qiu, Yipeng Zhao, Rui Li   +11 more
wiley   +1 more source

Single‐Nucleus Multiomic Analysis Reveals Immune–Metabolic Reprogramming Consistent With Maladaptive Trained Immunity in HIV‐Associated Neurocognitive Disorders

Glia, Volume 74, Issue 8, August 2026.
Single‐nucleus multiomic profiling of postmortem brain reveals coordinated immune, metabolic, and epigenomic reprogramming in glia of people with HIV consistent with maladaptive trained immunity sustaining neuroinflammation in HAND. ABSTRACT HIV‐associated neurocognitive disorders (HAND) remain prevalent in people with HIV (PWH) despite effective ...
Siera Martinez, Anelia Horvath, Luke Johnson, Tatiana Pushkarsky, Larisa Dubrovsky, Daria Starosyla, Ashley Bastin, Dmitri Sviridov, Michael Bukrinsky   +8 more
wiley   +1 more source

Passenger variants as pan‐clonal markers of pediatric AML: Implications for molecular MRD

HemaSphere, Volume 10, Issue 8, August 2026.
Abstract A streamlined, sensitive, and universal molecular method for MRD detection in pediatric AML remains an unmet clinical need. Here, we propose a novel approach based on tracking somatic non‐coding passenger variants. Using whole‐genome sequencing (WGS) of diagnostic bone marrow DNA, we identify patient‐specific somatic passenger variants, which ...
Ruth Shiloh, Dana Dayan, Ifat Geron, Maor Cohen, Tamar Feuerstein, Jorge Cano‐Nistal, Nurit Gal‐Mark, Shlomit Barzilai‐Birenboim, Dafna Gaash, Michal Hameiri‐Grossman, Avraham Kahan, Jamal Mahajna, Nino Oniashvili, Hava Rosenfeld, Dan Scharf, Keren Shichrur, Elena Shinderman‐Maman, Sarah Elitzur, Yehudit Birger, Shai Izraeli, Yosef E. Maruvka   +20 more
wiley   +1 more source

Kinetochore mutations and histone phosphorylation pattern changes accompany holo- and macro-monocentromere evolution. [PDF]

Nat Commun
Kuo YT, Neumann P, Chen J, Fuchs J, Schubert V, Kumke K, Sader MA, Melzer M, Zhu Z, Himmelbach A, Hentrich H, Macas J, Houben A.   +12 more
europepmc   +1 more source

Contrasting Effects of HT‐2 Toxin Exposure and ZIP6 Knockdown on Chondrocyte Extracellular Matrix Metabolism

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
HT‐2 toxin triggers chondrocyte damage and matrix metabolism disorders in KBD via suppressing ZIP6. ZIP6 knockdown alleviates these dysfunctions through FoxO, cAMP and TNF pathways, clarifying the molecular mechanism of cartilage injury. ABSTRACT Kashin‐Beck disease (KBD) is a chronic, endemic osteoarticular disorder associated with T‐2 toxin exposure,
Yang Liu, Yu Zhang, Ruitian Huang, Lulu Bai, Lian Liu, Chaowei Wang, Yirong Qin, Hui Wang, Xiong Guo, Xi Wang, Yujie Ning   +10 more
wiley   +1 more source

"End-to-End Chromosome Fusion" as the Main Driver of Descending Dysploidy in <i>Vigna lasiocarpa</i> (Mart. ex Benth.) Verdc. (Leguminosae Juss.). [PDF]

Plants (Basel)
Serafim L, Silva JH, Dias S, Oliveira ARDS, Nunes MC, da Costa AF, Benko-Iseppon AM, Jiang J, do Vale Martins L, Brasileiro-Vidal AC.   +9 more
europepmc   +1 more source

Targeting Melanoma‐Specific Tyrosinase Disrupts Cytoskeleton Dynamics for Precision Apoptosis Induction by a De Novo Designed Cyclic Peptide

MedComm, Volume 7, Issue 8, August 2026.
This study develops a tyrosinase‐activated cyclic peptide self‐assembly system to combat drug‐resistant melanoma. Cyclization of tyrosine/lysine‐rich peptides via ortho‐phthalaldehyde enables tyrosinase‐triggered quinone formation and nanostructure assembly, disrupting melanoma cell cytoskeletons by blocking actin polymerization and inducing apoptosis.
Ruoyang Zhao, Xiaowei Wang, Jiajia Hu, Yonghan Zhang, Xinmin Zhao, Qianqian Hu, Yajin Wen, Yuxin Jiao, Huabin Zhu, Fan Yang, Qingqing Sun, Jun Guo, Feng Zhang, Min Wu   +13 more
wiley   +1 more source

Asymmetric evolution of satellite DNA on homologous and homeologous chromosomes in allotetraploid Narenga porphyrocoma. [PDF]

BMC Plant Biol
Huang S, Zhang M, Yang Y, Yang J, Wang Z, Deng Z, Xu L, Huang Y.   +7 more
europepmc   +1 more source

ASK1‐Induced FGF21 Synthesis in the Liver Prevents Obesity in Mice

Obesity, Volume 34, Issue 8, Page 1635-1646, August 2026.
ABSTRACT Objective Fibroblast growth factor 21 (FGF21) is a stress‐induced hormone secreted by the liver. It has a beneficial role in the regulation of glucose and energy metabolism. Herein, we identify apoptosis signal regulating kinase 1 (ASK1) as an inducer of hepatic FGF21 synthesis.
Anne Goergen, Tenagne D. Challa, Carlos Villaroel‐Vicente, Marcela Borsigova, Pim P. van Krieken, Christian Wolfrum, Matthias Blüher, Stephan Wueest, Daniel Konrad   +8 more
wiley   +1 more source

Characterization of a New Powdery Mildew Resistance Gene on Chromosome 1R from Hexaploid Triticale Transferred to Wheat. [PDF]

Plants (Basel)
Luo Y, Jiang C, Li L, Jiang T, Tan JYT, Boro A, Yang E, Li G, Yang Z.   +8 more
europepmc   +1 more source