Results 101 to 110 of about 18,346 (233)

The association of thrombocytopenia with haematological malignancy

British Journal of Haematology, EarlyView.
This review article discusses the interplay of immune dysregulation, clonality, and immunosuppressive therapies in immune thrombocytopenia and how this links to the risk of misattribution versus the development of haematological malignancy. Unresolved questions and directions for future research are also discussed. Isolated thrombocytopenia is commonly
Abi Vijenthira, Henrik Frederiksen, Michelle Sholzberg   +2 more
wiley   +1 more source

A phenotype of resiliency? cross-sectional psychobiological differences between caregivers who are vulnerable vs. resilient to depression, and controls [PDF]

, 2016
Introduction: Being a caregiver of chronically ill children is a source of chronic-psychological stress affecting general physical and mental health.
Bersani, F. S., Epel, E. S., Wolkowitz, O. M.   +2 more
core  

7 Tesla MRI of Balo's concentric sclerosis versus multiple sclerosis lesions [PDF]

, 2018
Background: Baló’s concentric sclerosis (BCS) is a rare condition characterized by concentrically layered white matter lesions. While its pathogenesis is unknown, hypoxia-induced tissue injury and chemotactic stimuli have been proposed as potential ...
Behrens, Janina R., Bellmann-Strobl, Judith, Giess, René M., Harms, Lutz, Jarius, Sven, Kuchling, Joseph, Niendorf, Thoralf, Ostendorf, Lennard, Paul, Friedemann, Ruprecht, Klemens, Scheel, Michael, Sinnecker, Tim, Wanner, Julia, Wildemann, Brigitte, Wuerfel, Jens   +14 more
core   +2 more sources

Single Cell Multi‐Omics Revealing the Important Role of MR1 Mediated MAIT Cells in Maintaining Rejection for Liver Transplantation

Cell Proliferation, EarlyView.
This multi‐omics study reveals the significant role of MAIT cells in liver transplant rejection. MAIT cells drive rejection in liver transplantation via the MR1 axis. Their absence reshapes T cell responses and clonal expansion, attenuating allograft injury.
Hailun Cai, Xinqiang Li, Xin Zhou, Xueteng Wang, Zhuoyu Jia, Ruidong Ding, Yurong Luo, Ye Wang, Shipeng Li, Wenxing Sun, Dongxing Wu, Dahong Teng, Kai Zhao, Guanghui Pei, Jinzhen Cai, Bin Wu   +15 more
wiley   +1 more source

Comportamiento del resultado de las Bandas oligoclonales en líquidocefalorraquídeo en Pacientes con esclerosis múltiple del Hospital Militar Centra [PDF]

, 2013
La esclerosis múltiple es la enfermedad neurológica más común y discapacitante en adultos jóvenes1 en Colombia se estima una prevalencia de 1,48 a 4,98 casos por 100.000 habitantes.
Cabrera Limpias, Sergio, González, Juan Carlos   +1 more
core  

Alterations in Cerebrospinal Fluid in Patients with Bipolar Syndromes [PDF]

, 2016
Bipolar disorder (BD) is a severe and lifelong condition. Primary endogenic polygenetic forms are common. Secondary organic forms have received increasing interest recently due to the detection of immunological encephalopathies that mimic various ...
Benedikt Hochstuhl, Dietrich van Calker, Dietrich van Calker, Dominique Endres, Evgeniy Perlov, Ludger Tebartz Van Elst, Nils Venhoff, Oliver Stich, Rick Dersch, Simon Maier, Tilman Hottenrott   +10 more
core   +2 more sources

Lack of common TCRA and TCRB clonotypes in CD8+/ TCRαβ+ T-cell large granular lymphocyte leukemia: A review on the role of antigenic selection in the immunopathogenesis of CD8+ T-LGL [PDF]

, 2014
Clonal CD8 +/T-cell receptor (TCR)αβ+ T-cell large granular lymphocyte (T-LGL) proliferations constitute the most common subtype of T-LGL leukemia.
Darzentas, N. (Nikos), Dik, W.A. (Willem), Dongen, J.J.M. (Jacques) van, Gastel-Mol, E.J. (Ellen) van, Kallemeijn, M.J. (Martine), Langerak, A.W. (Anton), Pol, Y. (Y.), Sandberg, Y. (Yorick), Szczepanski, T. (Tomasz), Tielemans, D., Wolvers-Tettero, I.L.M. (I. L M)   +10 more
core   +1 more source

Immune dysregulation in mania: A proof‐of‐concept platelet proteomics study

Psychiatry and Clinical Neurosciences, EarlyView.
Aims Bipolar disorder (BD) is a major psychiatric condition with a multifaceted and largely unknown pathophysiology. Mania, the defining feature of BD, remains underinvestigated. Proteomics offers a powerful, data‐driven, unbiased approach to uncover biological alterations.
Paola Magioncalda, Matteo Martino, Nhi Thao Ngoc Le, Wen‐Yin Chen, Ming‐Chyi Huang, David Blum, Thierry Burnouf   +6 more
wiley   +1 more source

Isoelectric focusing of cerebrospinal fluid significance in differential diagnosis of multiple sclerosis [PDF]

Scripta Medica
Background/Aim: Isoelectric focusing (IEF) of cerebrospinal fluid (CSF) is the gold standard for detecting intrathecal oligoclonal immunoglobulin G (IgG). Besides its diagnostic and predictive significance, the IEF method also has differential diagnostic
Grgić Sanja, Dominović-Kovačević Aleksandra, Vukojević Zoran, Tadić Daliborka, Nazalević-Bursać Majda   +4 more
doaj   +1 more source

Regulatory role of vitamin D in T-cell reactivity against myelin peptides in relapsing-remitting multiple sclerosis patients [PDF]

, 2012
Background: Low levels of plasma 25-hydroxyvitaminD (25(OH)D) are associated with a higher incidence of multiple sclerosis (MS) due to the immune suppressive properties of vitamin D.
Borràs, Francesc E, Granada Ybern, María Luisa, Grau López, Laia, Martínez Cáceres, Eva María, Naranjo-Gómez, Mar, Ramo Tello, Cristina, Raïch Regué, Dàlia   +6 more
core   +3 more sources