Impaired myelination in multiple sclerosis organoids: p21 links oligodendrocyte dysfunction to disease subtype. [PDF]
Sadiq SA +4 more
europepmc +1 more source
Seeing Invisible Oligomers: Rethinking α‐Synuclein Pathology Through Proximity Ligation Assay
Abstract Parkinson's disease (PD) and multiple system atrophy are defined by α‐synuclein (αSYN)‐positive inclusions – Lewy bodies (LBs) and glial cytoplasmic inclusions – yet mounting evidence indicates that these inclusions represent only a fraction of disease‐relevant pathology.
Hiroaki Sekiya +3 more
wiley +1 more source
Brain-wide mapping of oligodendrocyte organization, oligodendrogenesis, and myelin injury. [PDF]
Xu YKT +10 more
europepmc +1 more source
Glial D-serine modulates oligodendrocyte lineage progression under inflammatory conditions. [PDF]
Espinoza JP +4 more
europepmc +1 more source
ABSTRACT Despite their widespread use as a research model, a comprehensive, quantitative proteomic profile of the cultured hippocampal neurons has remained unexplored. Here, we provide the first global proteomic characterization of primary murine hippocampal neurons cultured for 14 days under near‐physiological glucose conditions (2.5 mM).
Dominika Drulis‐Fajdasz +6 more
wiley +1 more source
Glia Are Bussin': How Single-Cell and Spatial Transcriptomics Enlighten the Role of Neuroglia in Spinal Cord Injury and Regeneration. [PDF]
Mejia J, Horner PJ.
europepmc +1 more source
Cancer therapies can trigger neuroinflammation and disrupted neuroplasticity, contributing to cognitive impairment and psychological distress in survivors. Stem cells (NSCs/MSCs) and their extracellular vesicles may restore neural niches via trophic support, immunomodulation, synaptic remodeling, and vascular repair, but require rigorous safety, dosing,
Xinyi Yang
wiley +1 more source
Effects of Tributyltin Chloride on Human Neuronal Differentiation and Mice Brain Development
ABSTRACT According to the developmental origins of health and disease hypothesis, perinatal exposure to an environmental toxicant during the development of the nervous system could cause a permanent cellular modification that may promote the appearance of neurodegenerative diseases at an older age.
Ester López‐Gallardo +10 more
wiley +1 more source
Loss of oligodendrocyte transcription factor 2 protein expression in metabolically stressed oligodendrocytes. [PDF]
Kaddatz H +11 more
europepmc +1 more source

