Results 191 to 200 of about 85,792 (299)

Sodium Ions Affect GPR17 Conformational States and Functionality

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Sodium is an allosteric modulator of several class‐A GPCR regulating active versus inactive conformation state and may be a critical issue for the optimization of crystallization procedures. Herein, the role of Na+ in the regulation of GPR17 conformational states was studied through MD simulations of GPR17 wild‐type and mutated on two ...
Luca Palazzolo, Simona Daniele, Davide Bianchi, Lara Russo, Stefano Capaldi, Maria Letizia Trincavelli, Ivano Eberini   +6 more
wiley   +1 more source

Cell autonomous regional differences in oligodendrocyte lineage development and responses to oncohistone H3.3 K27M. [PDF]

Nat Commun
Andrews JM, Budd KM, Kwon CH, Larson JD, Shirinifard A, Kasper LH, Williams CC, Lavado A, King S, Gutierrez J, Stabley D, Lin T, Lewis SA, Northcott PA, Onar-Thomas A, Baker SJ.   +15 more
europepmc   +1 more source

Hinokitiol Promotes Neural Repair After Spinal Cord Injury by Reprogramming Microglial Inflammatory and Redox Responses

Phytotherapy Research, EarlyView.
Schematic illustration showing that Hinokitiol promotes neural repair after spinal cord injury by activating the Keap1/Nrf2/HO‐1 signaling pathway and reprogramming microglial inflammatory‐redox responses. ABSTRACT Secondary neuroinflammation and oxidative stress, driven partly by maladaptive microglial activation, limit recovery after spinal cord ...
Wenhao Zhang, Jing Wang, Tianyi Wang, Qihao Fu, Jiawen Xu, Chaochen Li, Zheng Zhou, Chenxi Zhang, Guanhua Xu, Mingjie Xia, Zhiming Cui   +10 more
wiley   +1 more source

From oxidative stress to epigenetic regulation: Molecular mechanisms of preterm brain injury and neuroprotective strategies (Review). [PDF]

Mol Med Rep
Li Y, Wei L, Sun F, Wu H, Sun X, Gan Y, Kong X.   +6 more
europepmc   +1 more source

Protective Potentials of Natural Products Against Vascular Dementia: A Comprehensive Review of Experimental Studies

Phytotherapy Research, EarlyView.
ABSTRACT Vascular dementia (VaD), accounting for up to 20% of dementia cases globally, is primarily driven by chronic cerebral hypoperfusion (CCH), which leads to progressive cognitive impairment. Despite the increasing prevalence of VaD, effective treatments remain limited.
Jung‐Hoon Kim, Yongtaek Oh, Suin Cho
wiley   +1 more source

Oligodendrocyte failure in ALS [PDF]

Nature Neuroscience, 2013
openaire   +2 more sources

Tailoring MXene Flake Morphology via Aerosol Jet Printing for Biological and Strain Sensor Applications

Small, EarlyView.
Aerosol Jet Printing (AJP), coupled with a novel in situ monitoring method, enabled the controlled fabrication of aligned and crumpled Ti3C2Tx MXenes for diverse applications. Demonstrated across multiple 2D materials, this scalable strategy stablishes flake morphology as a controllable design parameter for engineering application‐specific material ...
Javier Gutierrez‐Gonzalez, Dahnan Spurling, Cian O'Connor, Eoin Caffrey, Tara McGuire, Jack Maughan, Tian Carey, Jose Munuera, Ilias M. Oikonomou, Julian Carolan, Luke Doolan, Ian Woods, Giulio Brunetti, Maeve A. Caldwell, Adrian Dervan, Richard G. Hobbs, Jonathan N. Coleman, Valeria Nicolosi, Fergal J. O'Brien   +18 more
wiley   +1 more source

Human Mesenchymal Stromal Cells Attenuate Hyperoxia-Induced Cellular Impairment of Immature Oligodendrocyte and Neurons. [PDF]

Cells
Serdar M, Kempe K, Herz J, Ricci F, Felderhoff-Müser U, Bendix I.   +5 more
europepmc   +1 more source

Innovative 3D‐bioprinted microfibers in calcium phosphate cement platform with Nell‐1 to activate nerve‐bone axis for synergistic bone, vasculature, and nanofibrous nerve regeneration

Smart Molecules, EarlyView.
A 3D‐bioprinted platform with stem cells activates “nerve‐bone” signaling by enabling the spatiotemporal delivery of Nell‐1. This activation enhances neurovascular and bone regeneration through the CYFIP1 cascade. In rat calvarial defects, the platform doubled bone regeneration and nerve repair and tripled vascular density, resulting in superior ...
Minjia Zhu, Xinyi Li, Jingyi Li, Kan Yu, Zixiang Dai, Le Xiao, Qinrou Zhang, Zihan Jia, Qingchen Qiao, Zeqing Zhao, Ke Zhang, Yuxing Bai   +11 more
wiley   +1 more source

Multifaceted response of microglia in the cuprizone model of demyelination. [PDF]

PLoS One
Shanahan A, Eichfeld G, Todd L, Niraula A.   +3 more
europepmc   +1 more source