Results 201 to 210 of about 85,792 (299)

Patient‐derived surgical samples reveal the cellular and molecular signatures of glioblastoma infiltration in distinct radiological zones

Brain Pathology, EarlyView.
Integrated histological and transcriptional profiling of the glioblastoma periphery reveals clinically relevant tumor infiltration beyond MRI‐defined boundaries. MRI‐guided biopsies from contrast‐enhancing (CE), non‐contrast‐enhancing (nCE), edema (E), and radiologically normal (N) regions demonstrate that nCE areas frequently retain neoplastic and ...
Olaya de Dios, Juan Romero, María de los Ángeles Ramírez‐González, Beatriz Herranz, Alicia Avis‐Bodas, Juliana Manosalva, Diego Megías, Ana Ramos, Juan Manuel Sepúlveda‐Sánchez, Ricardo Gargini, Berta Segura‐Collar, Gabriel Velilla, Bárbara Meléndez, Pedro González, Luis Jiménez‐Roldán, Guillermo García‐Posadas, Aurelio Hernández‐Laín, Ángel Pérez‐Núñez, Pilar Sánchez‐Gómez   +18 more
wiley   +1 more source

A single-cell transcriptomic atlas of the periventricular proliferative zone in the late gestation fetal brain in the pigtail macaque. [PDF]

Front Neurosci
Cornelius JA, Shivakumar M, Kim T, Cervantes O, Kapur RP, Huang H, Zhao H, Del Rosario BM, Li A, Li RJ, Sun S, Vo AE, Manuel G, Bharadwaj A, Munson J, Li M, Li E, Chima S, Orvis A, Coleman M, Christodolou A, Berg MR, Curtis BC, Menz BA, Dai J, Golez ID, Wangari SN, McCartney SA, Noble K, Flores-Espinoza P, Helguera-Repetto AC, Olmos-Ortiz A, Fonseca-Perez MS, English C, Baldessari A, Gomez-Lopez N, Hodge R, Rajagopal L, Adams Waldorf KM.   +38 more
europepmc   +1 more source

Dysregulated TIE‐2 expression is associated with blood‐brain barrier leakiness and Alzheimer's disease‐related neuropathology

Brain Pathology, EarlyView.
Ince et al., have analysed TIE‐1 and ‐2 expression in human brain tissue, including microvessel‐enriched fractions (MVF) and covering a spectrum of AD‐associated pathology, and in CSF from independent cohorts spanning a clinical spectrum from normal cognition to AD.
Selvi Ince, Carol Van Hulle, Gwendlyn Kollmorgen, Clara Quijano‐Rubio, Carey Gleason, Barbara B. Bendlin, Ozioma Okonkwo, Sanjay Asthana, Kaj Blennow, Henrik Zetterberg, Sterling C. Johnson, Seth Love, J. Scott Miners   +12 more
wiley   +1 more source

Glial heterogeneity shapes region-specific angiogenesis and neurovascular integrity in the CNS. [PDF]

Sci Adv
Shen M, Li Z, Huang G, Zhang Y, Wen S, Guo F, Guo Y, Zhang L, He X.   +8 more
europepmc   +1 more source

CRYAB is compromised in pathologically affected oligodendrocytes in multiple system atrophy

Brain Pathology, EarlyView.
CRYAB is hypermethylated and colocalizes with α‐synuclein in multiple system atrophy oligodendrocytes.
Finula I. Isik, Jen‐Hsiang T. Hsiao, Felicia Xaveria Suteja, Shrey Shahdadpuri, Nicolas Dzamko, Glenda M. Halliday, Woojin Scott Kim, YuHong Fu   +7 more
wiley   +1 more source

Distinctly altered TRPC3 and TRPC6 expression patterns in human Alzheimer's disease cortex and hippocampus

Brain Pathology, EarlyView.
Divergent remodeling of TRPC channels occurs in Alzheimer's disease, with TRPC3 increased in neurons and reactive astrocytes and TRPC6 reduced in pyramidal neurons. These alterations may contribute to calcium dysregulation, neuroinflammation, and synaptic dysfunction during AD progression.
Xingyong Chen, Zhengjun Wang, Jiaxing Wang, Dehui Kong, Xusheng Wang, Lu Lu, Peter T. Nelson, Fu‐Ming Zhou, Francesca‐Fang Liao   +8 more
wiley   +1 more source

Oligodendrocyte prosaposin restores subarachnoid haemorrhage-induced consciousness impairment. [PDF]

Exp Mol Med
Li H, Li X, Xu Z, Cao C, Lu J, Ding H, Bai L, Tao J, Peng L, Tang J, Chen G.   +10 more
europepmc   +1 more source

From patient to tumor organoid: Culture protocol choice controls glioblastoma tumor architecture and identity

Brain Pathology, EarlyView.
How glioblastoma organoids are made shapes what they become. Fragment‐based cultures preserve extracellular matrix networks, cellular diversity, and primary tumor identity, whereas dissociation‐based cultures shift toward growth‐adapted states and simplified microenvironments. Abstract Patient‐derived tumor organoids are widely used in cancer research,
Jana Slovackova, Ondrej Bernatik, Katarina Cimborova, Martin Barak, Michal Hendrych, Karolina Kocourkova, Marie Sulcova, Jaroslav Olha, Katerina Amruz Cerna, Zdenek Hodny, Radim Jancalek, Dasa Bohaciakova   +11 more
wiley   +1 more source

Profiling miRNAs Involved in Human Oligodendrocyte Precursor Cell Differentiation and Maturation. [PDF]

Cells
Barzegar M, Dhukhwa A, Patel VN, Velasquez FC, Das S, Patil AH, Halushka MK, Chamling X.   +7 more
europepmc   +1 more source