Results 201 to 210 of about 66,933 (261)

Integrative epigenomic landscape of Alzheimer's Disease brains reveals oligodendrocyte molecular perturbations associated with tau. [PDF]

Nat Commun
Oatman SR, Reddy JS, Atashgaran A, Wang X, Min Y, Quicksall Z, Vanelderen F, Carrasquillo MM, Liu CC, Yamazaki Y, Nguyen TT, Heckman M, Zhao N, DeTure M, Murray ME, Bu G, Kanekiyo T, Dickson DW, Allen M, Ertekin-Taner N.   +19 more
europepmc   +1 more source

Early Myelination Supports the Establishment of Consistent Handedness

Glia, Volume 74, Issue 7, July 2026.
Early compact myelin is essential for the establishment but not the maintenance of consistent paw preference in mice. Congenital myelin absence reduces lateralization and creates a leftward bias, underscoring a developmental role in shaping brain asymmetries. ABSTRACT Lateralization of brain functions, such as handedness, is thought to enhance cortical
Sharlen Moore, Swati Subramanian, Martin Meschkat, Jonas W. Hemesath, Torben Ruhwedel, Wiebke Möbius, Klaus‐Armin Nave, Livia de Hoz   +7 more
wiley   +1 more source

Therapeutic targeting of oligodendrocytes in an agent-based model of multiple sclerosis. [PDF]

PLoS Comput Biol
Weatherley GR, Araujo RP, Dando SJ, Jenner AL.   +3 more
europepmc   +1 more source

Reduced SH3RF3 May Protect Against Alzheimer's Disease by Lowering Microglial Pro‐Inflammatory Responses via Modulation of JNK and NFkB Signaling

Glia, Volume 74, Issue 7, July 2026.
SNPs in SH3RF3 decrease the age of onset of Alzheimer's disease (AD). Reduced SH3RF3 blunts human microglial JNK and NFkB signaling and downstream inflammatory cytokine production, which may partially explain how SH3RF3 SNPs protect against AD. ABSTRACT Understanding how high‐risk individuals are protected from Alzheimer's disease (AD) may illuminate ...
Ronak Patel, Rong Cheng, Christopher L. Cardona, Ellen Angeles, Gunjandeep Singh, Sabrina Miller, Archana Ashok, Andrew F. Teich, Angel Piriz, Aleyda Maldonado, Ivonne Z. Jiménez‐Velázquez, Richard Mayeux, Joseph H. Lee, Andrew A. Sproul   +13 more
wiley   +1 more source

Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease Onset in Pregnancy: A Case Report. [PDF]

Cureus
Infante Valenzuela A, Saldaña Velázquez HA, Martínez Torres AS, García Garza DA, Villarreal Ondarza IA, Flores Alfaro F, Saldivar Dávila S, Chávez Luévanos BE, Góngora-Rivera F.   +8 more
europepmc   +1 more source

Astrocyte Mechanobiology: Linking Biomechanical Forces to Biochemical Signaling in the Central Nervous System

Glia, Volume 74, Issue 7, July 2026.
Astrocytes are key sensors and transducers of biomechanical stimuli within the central nervous system. Astrocyte development is highly dependent on mechanical stimuli such as surrounding tissue stiffness and biomechanical strain. Mechanosensory pathways including integrins, connexins and pannexins, and mechanosensitive channels regulate astrocyte ...
Ana N. Strat, Alima Ahmed, Mariano Viapiano, Preethi S. Ganapathy   +3 more
wiley   +1 more source

Molecular and biochemical correlates of frontal lobe white matter degeneration in humans with alcohol use disorder. [PDF]

Adv Drug Alcohol Res
de la Monte SM, Tong M, Sutherland G.
europepmc   +1 more source

Ischemia–Reperfusion Injury: Molecular Mechanisms and Therapeutic Interventions

MedComm, Volume 7, Issue 7, July 2026.
Multiorgan ischemia–reperfusion injury begins with ischemia‐induced ATP depletion and ionic imbalance, followed by reperfusion‐triggered mitochondrial ROS/RNS bursts, regulated cell death, and DAMP release. Sterile inflammation converges on endothelial–immune–coagulation crosstalk, where NETs drive immunothrombosis, no‐reflow, and remote organ injury ...
Peng An, Yi An, Mengwei Chen, Longlong Wu, Rong Wang   +4 more
wiley   +1 more source

Molecular Mimicry Between Epstein-Barr Virus and Human Herpesvirus-6 Proteins and Central Nervous System Proteins: Implications for T and B Cell Immunogenicity in an In Silico Study. [PDF]

Immun Inflamm Dis
Almulla AF, Normatov MG, Supasitthumrong T, Maes M.   +3 more
europepmc   +1 more source

Single-cell sequencing reveals reversible glial remodeling in the visual cortex during visual deprivation and recovery. [PDF]

Front Immunol
Gong X, Feng J, Xu Z, Xie Y, Han Y, Li J, Tang G, Liu Y, Dong X, Li S, Zhang J, Wang J, Liu R, Song J, Bi H.   +14 more
europepmc   +1 more source