Results 211 to 220 of about 85,792 (299)

Development and Differentiation of Oligodendrocytes.

The Japanese Journal of Physiology, 1996
YAMADA, Masahisa, KAGAWA, Tetsushi, IKENAKA, Kazuhiro   +2 more
openaire   +3 more sources

The immunological landscape of the area postrema in neuromyelitis optica spectrum disorders

Brain Pathology, EarlyView.
Aquaporin‐4 antibody‐positive neuromyelitis spectrum disorder is characterized by large tissue destructive lesions in medulla, spinal cord, and optic nerves, with only partial recovery from clinical symptoms, and by lesions with very little tissue destruction and mostly complete recovery from clinical symptoms, as seen in the area postrema ...
Qian Yu, Yoshiki Takai, Naoya Yamazaki, Sarah Brandl, Katharina M. Mair, Thibault Bouderlique, Maria Eleni Kastriti, Igor Adameyko, Romana Höftberger, Markus Reindl, Jan Bauer, Monika Bradl   +11 more
wiley   +1 more source

Developmental oligodendrocytes regulate brain function through the mediation of synchronized spontaneous activity. [PDF]

Elife
Masumura R, Goda K, Sekiguchi M, Uesaka N.   +3 more
europepmc   +1 more source

α‐Synuclein strain homogeneity in multiple system atrophy subtypes

Brain Pathology, EarlyView.
Two different subtypes of multiple system atrophy are recognized: MSA‐C and MSA‐P. In this manuscript, Lau et al. investigate whether MSA‐C and MSA‐P are caused by different strains of α‐synuclein aggregates. By performing conformational fingerprinting experiments as well as in vitro and in vivo seeding assays, their findings suggest that both MSA‐C ...
Heather H. C. Lau, Nicholas R. G. Silver, Surabhi Mehra, Raphaella W. L. So, Le yao Li, Alison Mao, Erica Stuart, Cian Schmitt‐Ulms, Bradley T. Hyman, Martin Ingelsson, Joel C. Watts   +10 more
wiley   +1 more source

When myelin breaks, tau aggregates - a new perspective on Alzheimer's disease. [PDF]

Alzheimers Dement
Tiane A, van den Hove D, Vanmierlo T.
europepmc   +1 more source

Brain calcification‐associated JAM2 pathogenic mutations impair JAM2–JAM3 tight junction structure and the blood–brain barrier integrity

Brain Pathology, EarlyView.
Pathogenic JAM2 mutations disrupt the JAM2–JAM3 heterodimer structure and tight junction integrity, leading to blood–brain barrier breakdown. Consequently, Jam2‐deficient mice develop prominent midbrain calcification and significant motor impairments, identifying the JAM2–JAM3 interaction as a vital target for primary brain calcification therapeutics ...
Dehao Yang, Lebo Wang, Chenxin Ying, Yihua Shi, Yuru Guo, Haotian Wang, Xinhui Chen, Yaoting Wang, Xinchen Wang, Fan Zhang, Xiaosheng Zheng, Yiling Chen, Haoyu Wang, Zhiru Lin, Jiaxiang Li, Haibin Xia, Jiawen Chen, Feng Fu, Bo Wang, Sheng Wu, Ping Wang, Fei Xie, Zhidong Cen, Zhiping Wang, Wei Luo   +24 more
wiley   +1 more source

Controllability Analysis of Intercellular Protein-Protein Interaction Networks. [PDF]

Comput Struct Biotechnol J
Nozaki H, Tsuchiya K, Akutsu T, Nacher JC.   +3 more
europepmc   +1 more source

Compartmentalisation in cAMP signalling: A phase separation perspective

British Journal of Pharmacology, EarlyView.
Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley   +1 more source

Selective GPR17 antagonism enhances structural and functional recovery in animal models of demyelination. [PDF]

PLoS One
De Herdt D, Lefevere E, Brouwers V, Hartvig L, Geeraerts E, Hsiao CC, Chen JQA, Pinto R, Duvey G, Burbidge S, Harmeier A, Knuesel I.   +11 more
europepmc   +1 more source

Therapeutic access points: The roles of circumventricular organs in drug delivery and metabolic regulation

British Journal of Pharmacology, EarlyView.
The current obesity drug landscape, dominated by GLP‐1 receptor agonists and emerging multi‐agonist therapies, has reinforced that long‐term weight loss is achieved in large part through central mechanisms that suppress appetite and reshape energy balance.
Ines Martinez‐Corral, Nicholas Monaco, Daniel I. Brierley, Monica Imbernon   +3 more
wiley   +1 more source