Results 231 to 240 of about 66,933 (261)
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Oligodendrocytes and Alzheimer's disease
International Journal of Neuroscience, 2015Extensive evidence has indicated that the breakdown of myelin is associated with Alzheimer's disease (AD) since the vulnerability of oligodendrocytes under Alzheimer's pathology easily induces the myelin breakdown and the loss of the myelin sheath which might be the initiating step in the changes of the earliest stage of AD prior to appearance of ...
Zhiyou, Cai, Ming, Xiao
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The oligodendrocytic junctional complex
Cell and Tissue Research, 1978The junctional complex of oligodendrocytes was studied by means of different electron microscopical techniques. This complex is composed of the following junctional membrane formations: 1) tight junctional domains in the oligodendrocytic membrane near the some of the cells, 2) fasciae occludentes or focal tight junctions on the outer oligodendrocytic ...
R, Dermietzel, D, Schünke, A, Leibstein
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Regulation of oligodendrocyte development
Microscopy Research and Technique, 2001AbstractOligodendrocytes are myelinating cells in the central nervous system. Recent studies demonstrated that oligodendrocyte progenitor cells are generated from a restricted region in the ventricular zone. In the rodent spinal cord, progenitor cells appear from narrow and bilateral longitudinal columns in the ventral ventricular zone, and then ...
T, Kagawa, T, Wada, K, Ikenaka
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Telomerase and oligodendrocyte differentiation
Journal of Neurobiology, 2001AbstractMyelin in the mammalian central nervous system (CNS) is produced by oligodendrocytes, most of which arise from oligodendrocyte precursor cells (OPCs) during late embryonic and early postnatal development. Both external and internal cues have been implicated in regulating OPC exit from the cell cycle and differentiation into oligodendrocytes. In
G L, Caporaso, M V, Chao
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Oligodendrocyte degeneration in AD
Neurobiology of Aging, 2004Most would agree with a description of Alzheimer’s disease (AD) primarily as a degeneration of the cerebral cortex. As a result, much laboratory research in the past decade has focused on the cell death mechanisms of neurons. However, it may be time broaden the focus of AD research to include dysfunction of the tracts that connect cortical areas.
G T, Whitman, C W, Cotman
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Regulators of Oligodendrocyte Differentiation
Cold Spring Harbor Perspectives in BiologyMyelination has evolved as a mechanism to ensure fast and efficient propagation of nerve impulses along axons. Within the central nervous system (CNS), myelination is carried out by highly specialized glial cells, oligodendrocytes. The formation of myelin is a prolonged aspect of CNS development that occurs well into adulthood in humans, continuing ...
Ben, Emery, Teresa L, Wood
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An Overview of Oligodendrocyte Metabolism
Oligodendrocytes (OLs) exhibit complex metabolic interactions essential for neuronal function and CNS health. This chapter analyzes the metabolism of OLs, particularly glucose, lipid, and amino acid metabolism, and their impact on myelin synthesis, maintenance, and CNS resilience.Qi, Han, Jin, Cheng
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Structure and Function of Oligodendrocytes
2004This chapter deals with the morphology of oligodendrocytes. The first section reviews current findings on the morphology of oligodendrocytes and discusses these findings in the context of the classical work by Rio–Hortega. The second section examines the functional significance of oligodendrocyte polymorphism, and the third deals with the environmental
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