Results 1 to 10 of about 92,702 (304)

Anti-EFG1 2′-OMethylRNA oligomer inhibits Candida albicans filamentation and attenuates the candidiasis in Galleria mellonella

Molecular Therapy: Nucleic Acids, 2022
EFG1 is a central transcriptional regulator of filamentation that is an important virulence factor of Candida albicans. This study serves to assess in vivo the applicability of the anti-EFG1 2′-OMethylRNA oligomer for inhibiting C. albicans filamentation
Daniela Araújo, Dalila Mil-Homens, Mariana Henriques, Sónia Silva   +3 more
doaj   +1 more source

Bacterial Cell Wall Analogue Peptides Control the Oligomeric States and Activity of the Glycopeptide Antibiotic Eremomycin: Solution NMR and Antimicrobial Studies

Pharmaceuticals, 2021
For some time, glycopeptide antibiotics have been considered the last line of defense against Methicillin-resistant Staphylococcus aureus (MRSA). However, vancomycin resistance of Gram-positive bacteria is an increasingly emerging worldwide health ...
László Izsépi, Réka Erdei, Anna N. Tevyashova, Natalia E. Grammatikova, Andrey E. Shchekotikhin, Pál Herczegh, Gyula Batta   +6 more
doaj   +1 more source

Less Is More: Oligomer Extraction and Hydrothermal Annealing Increase PDMS Adhesion Forces for Materials Studies and for Biology-Focused Microfluidic Applications

Micromachines, 2023
Cues in the micro-environment are key determinants in the emergence of complex cellular morphologies and functions. Primary among these is the presence of neighboring cells that form networks.
Larry J. Millet, Anika Jain, Martha U. Gillette   +2 more
doaj   +1 more source

Enhancing Immunogenicity of a Thermostable, Efficacious SARS-CoV-2 Vaccine Formulation through Oligomerization and Adjuvant Choice

Pharmaceutics, 2023
Currently deployed SARS-CoV-2 vaccines all require storage at refrigerated or sub-zero temperatures. We demonstrate that after month-long incubation at 37 °C, solubilization, and formulation with squalene-in-water emulsion adjuvant, a stabilized receptor
Mohammad Suhail Khan, Virginie Jakob, Randhir Singh, Raju S. Rajmani, Sahil Kumar, Céline Lemoine, Harry Kleanthous, Rajesh P. Ringe, Patrice M. Dubois, Raghavan Varadarajan   +9 more
doaj   +1 more source

Structure Performance Correlation of N-Heterocyclic Oligomer Leveler for Acid Copper Plating of Advanced Interconnects

Molecules, 2023
Levelers, as an essential part of organic additives in copper electroplating, play a crucial role in the fabrication of sophisticated interconnects in integrated circuits, packaging substrates, and printed circuit boards.
Chuan Peng, Yuehui Zhai, Xianming Chen, Chong Wang, Yan Hong, Yuanming Chen, Wei He, Guoyun Zhou, Binyun Liu   +8 more
doaj   +1 more source

The intracerebral injection of Aβ1-42 oligomers does not invariably alter seizure susceptibility in mice

Frontiers in Aging Neuroscience, 2023
ObjectivesEpileptiform activity and seizures are present in patients with Alzheimer’s disease (AD) and genetic animal models of AD. Amyloid beta 1-42 (Aβ1-42) oligomers are thought to be crucial in AD and can cause neuronal hyperexcitability in vitro ...
Maxime Vande Vyver, Maxime Vande Vyver, Maxime Vande Vyver, Maxime Vande Vyver, Louise Daeninck, Gino De Smet, Najat Aourz, Surajit Sahu, Sebastiaan Engelborghs, Sebastiaan Engelborghs, Sebastiaan Engelborghs, Kris Pauwels, Dimitri De Bundel, Ilse Smolders   +13 more
doaj   +1 more source

Properties of Polyhexamethylene Guanidine (PHMG) Associated with Fatal Lung Injury in Korea

Molecules, 2020
The use of humidifier disinfectant (HD) has been determined to be associated with lung injuries (HDLI) in Korea. Although HD brands containing polyhexamethylene guanidine (PHMG) oligomers have been found to cause more HDLI compared to brands containing ...
Dong-Uk Park, Jihoon Park, Kee Won Yang, Ju-Hyun Park, Jung-Hwan Kwon, Han Bin Oh   +5 more
doaj   +1 more source

Association of Plasma Oligomerized Beta Amyloid with Neurocognitive Battery Using Korean Version of Consortium to Establish a Registry for Alzheimer’s Disease in Health Screening Population

Diagnostics, 2020
The increasing prevalence of Alzheimer’s disease (AD) has become a global phenomenon presenting serious social and health challenges. For detecting early molecular changes in the disease, several techniques to measure varied species of amyloid beta in ...
Jung-Ju Lee, Youngki Choi, Soie Chung, Dae Hyun Yoon, Seung Ho Choi, Sung-Min Kang, David Seo, Kyung-Il Park   +7 more
doaj   +1 more source

Current Perspective on the Membrane-Damaging Action of Thermostable Direct Hemolysin, an Atypical Bacterial Pore-forming Toxin

Frontiers in Molecular Biosciences, 2021
Thermostable direct hemolysin (TDH) is the major virulence determinant of the gastroenteric bacterial pathogen Vibrio parahaemolyticus. TDH is a membrane-damaging pore-forming toxin (PFT).
Pratima Verma, Kausik Chattopadhyay
doaj   +1 more source

Pathologic light chain amyloidosis oligomer detection in urinary extracellular vesicles as a diagnostic tool for response and progression of disease

Frontiers in Oncology, 2022
Light Chain (AL) Amyloidosis is a plasma cell dyscrasia producing amyloidogenic light chains (LC) that misfold and form amyloid deposits that cause damage in vital organs, primarily the heart and kidneys.
Shawna A. Cooper, Christopher J. Dick, Pinaki Misra, Nelson Leung, Nelson Leung, Carrie A. Schinstock, Marina Ramirez-Alvarado, Marina Ramirez-Alvarado, Marina Ramirez-Alvarado   +8 more
doaj   +1 more source