Results 51 to 60 of about 190,260 (351)

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Amyloid-β oligomer Aβ*56 induces specific alterations of tau phosphorylation and neuronal signaling

Science Signaling, 2017
The 56-kDa amyloid-β oligomer triggers pathological tau aggregation through increased Ca2+ influx. A more pathological amyloid-β oligomer Amyloid-β (Aβ) is implicated in the pathology of Alzheimer’s disease (AD), and various types of Aβ oligomers emerge ...
Fatou Amar, Mathew A. Sherman, T. Rush, Megan Larson, G. Boyle, Liu Chang, J. Götz, A. Buisson, Sylvain E. Lesné   +8 more
semanticscholar   +1 more source

Oleuropein derivatives from olive fruit extracts reduce α-synuclein fibrillation and oligomer toxicity [PDF]

, 2019
Aggregation of α-synuclein (αSN) is implicated in neuronal degeneration in Parkinson's disease and has prompted searches for natural compounds inhibiting αSN aggregation and reducing its tendency to form toxic oligomers.
Lomax, Charlotte, Schafer, Nicholas P., Sahin, C., Mohammed-Beigi, H., Shafer, N.P., Tawfike, Ahmed, Lomax, C., Hosseini-Mazinani, M., Møller, Ian Max, Christiansen, Gunna, Morshedi, Dina, Ward, J. L., Sahin, Cagla, Moller, I.M., Tawfike, A., Otzen, Daniel E., Otzen, D.E, Hosseini-Mazinani, Mehdi, Christiansen, G., Amiri-Nowdijeh, A., Aliakbari, Farhang, Ward, Jane L., Morshedi, D., Mohammad-Beigi, Hossein, Amiri-Nowdijeh, Alireza, Aliakbari, F., Eskandari, Hoda, Eskandari, E.   +27 more
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

β-amyloid oligomers in aging and Alzheimer's disease

Frontiers in Aging Neuroscience, 2013
Alzheimer’s disease (AD) is a fatal neurodegenerative disorder, and the most common cause of dementia in the elderly. The cause of AD is not known, but genetic evidence strongly supports the hypothesis that pathological aggregation of the β-amyloid ...
Kathleen R. Zahs, Karen Hsiao Ashe, Karen Hsiao Ashe, Karen Hsiao Ashe   +3 more
doaj   +1 more source

Quantification of Multivalency in Protein-Oligomer-Coated Nanoparticles Targeting Dynamic Membrane Glycan Receptors

, 2018
Multivalent binding of proteins to glycan receptors on the host cell quantitatively controls the initial adhesion of most viruses. However, quantifying such multivalency in terms of binding valency has always been a challenge because of the hierarchy of ...
Xiaoyu Xia (122594), Jiake Lin (5485562), Lei Shen (76320), Kang Wang (415359)   +3 more
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Structural mapping of oligomeric intermediates in an amyloid assembly pathway

eLife, 2019
Transient oligomers are commonly formed in the early stages of amyloid assembly. Determining the structure(s) of these species and defining their role(s) in assembly is key to devising new routes to control disease.
Theodoros K Karamanos, Matthew P Jackson, Antonio N Calabrese, Sophia C Goodchild, Emma E Cawood, Gary S Thompson, Arnout P Kalverda, Eric W Hewitt, Sheena E Radford   +8 more
doaj   +1 more source

Solubilization and Photostabilization in a Sodium Deoxycholate Hydrogel of a Neutral Conjugated Thiophene Oligomer and Polymer [PDF]

Oligo(3-hexylthiophene-co-1,4-phenylene) and poly(3-hexylthiophene) were solubilized in sodium deoxycholate self-assemblies in water solutions and hydrogels.
Alessandra S., Menandro, Cornelia, Bohne, Laura O. , Péres   +2 more
core   +2 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source