Results 221 to 230 of about 635,743 (331)

Bifunctional oligonucleotide probes synthesized using a novel CPG support are able to detect single base pair mutations

, 1989
Paul S. Nelson, Roy A. Frye, Edison Liu
openalex   +2 more sources

Temporal Stretch‐Induced Nuclear Mechanosensing Coordinates Early Chromatin Accessibility and Genome Protection

Advanced Science, EarlyView.
Cyclic stretching of fibroblasts triggers coordinated nuclear mechanosensing events, including calcium ion release, perinuclear actin assembly, emerin translocation, and H3K9me3 loss, increasing chromatin accessibility for specific genes related to mechanotransduction and repair.
Hye‐Won Shim, Ji‐Young Yoon, Hwalim Lee, Shanika Karunasagara, Cheng Ji Li, Yongdae Shin, Sukbum Hong, Dong‐Joon Lee, Jung‐Hwan Lee, Kam W. Leong, Hae‐Won Kim   +10 more
wiley   +1 more source

An oligo-swapping method: preparation of mismatch repair-monitoring substrate using a nicking endonuclease. [PDF]

MethodsX
Takedachi A, Hayashida M, Kuraoka I.
europepmc   +1 more source

Anti-gene oligonucleotide clamps invade dsDNA and downregulate huntingtin expression

Tea Umek, Karin E. Lundin, Metoboroghene O. Mowoe, Yi Hao, Samantha Roudi, Lana Žura, Per T. Jørgensen, Chenguang Lou, Daniel W. Hagey, Jesper Wengel, Smith Rjh, Rula Zain   +11 more
openalex   +1 more source

FXYD3 Promotes Tumor Progression by Binding With IRF7 to Regulate JAK2/STAT5 Signaling in Intrahepatic Cholangiocarcinoma

Advanced Science, EarlyView.
FXYD3 binds IRF7 via its 60–87aa domain, triggering a cGAS/STING‐mediated positive feedback loop amplified by type I interferon. This sustains JAK2/STAT5 activation, accelerating ICC progression. Targeting FXYD3 with siFXYD3@PEP suppresses tumors and enhances chemotherapy sensitivity. Abstract Intrahepatic cholangiocarcinoma (ICC) has a poor prognosis,
Yan Zhou, Xiaofeng Shen, Shuo Zhang, XiaoHong Pu, Zipeng Xu, Xiang Zhao, Wei Feng, Yuan Liang, Xingtao He, Aihua Yang, Yudong Qiu, Yihang Yuan, Chaobo Chen, Jun Chen   +13 more
wiley   +1 more source

Development of Enhanced Separation Techniques for Oligonucleotides Utilizing Mixed-Mode Chromatography and 2D-LC/UV/MS Analysis. [PDF]

J Sep Sci
Haglöf J, Nilsson JM, Ludvigsson JW.
europepmc   +1 more source

Characterizing Stage‐Specific Cellular Dynamics and Microenvironmental Remodeling in Lung Adenocarcinoma by Single‐Cell RNA Sequencing

Advanced Science, EarlyView.
This study integrated early‐stage patient specimens with publicly available datasets encompassing non‐malignant lung tissues and advanced‐stage LUAD through single‐cell sequencing, revealing a dynamically remodeled tumor microenvironment characterized by a hypoxia‐adapted malignant subset (C5), immunosuppressive LGMN+ macrophages, STAT1‐driven ...
Bomiao Qing, Xiaolan Li, Xiang He, Junyi Wang, Yi Yang, Manling Jiang, Bingbing Yan, Lei Zhang, Anying Xiong, Qin Ran, Guoping Li   +10 more
wiley   +1 more source

Translational and clinical development of therapeutic siRNA and ASOs: current industry practices, perspectives, and recommendations. [PDF]

Nucleic Acids Res
Christensen JK, Colletti N, Hooshfar S, Jiang RR, Kuo C, Lindmark B, Lumen A, Youssef AS, Albertolle M, Aluri KC, Chen L, Chen J, Chopda G, Chua XY, Morais P, Dubois B, Gibbons FF, Gudey SK, Gupta S, Hood S, Humphreys S, Husser C, Huth F, Jani D, Jian W, Kakuda T, Kurz J, Linnebjerg H, Liu J, Lohmann S, Niu T, Root K, Singla S, Tang C, Veluri R, Zhang GS, Zhang S, Jawa V.   +37 more
europepmc   +1 more source

Apolipoprotein E2(Arg158----Cys) frequency in a hyperlipidemic French-Canadian population of apolipoprotein E2/2 subjects. Determination by synthetic oligonucleotide probes.

, 1989
Karl H. Weisgraber, Yvonne M. Newhouse, John M. Taylor, Bertrand Tuan, A.C. Nestruck, Jean Davignon, Robert W. Mahley   +6 more
openalex   +1 more source

Piezo1 Upregulation in Monocyte‐Derived Macrophages Impairs Post‐Myocardial Infarction Cardiac Repair via Defective Efferocytosis and Enhanced Ferroptosis

Advanced Science, EarlyView.
This study reports early Piezo1 activation in bone marrow monocyte‐derived macrophages (MoMs) during myocardial infarction (MI), which governs the fate and function of recruited macrophages. The recruited MoMs with increased Piezo1 expression exhibit increased ferroptosis and defective efferocytosis, delayed clearance of dead cells and resolution of ...
Lu Peng, Yunlong Xia, Huishou Zhao, Yongzhen Guo, Xiaoming Xu, Xue Han, Shiyue Wang, Fengyue Ding, Quanchi Liu, Congye Li, Yuan He, Zhaoyi Luo, Qiaojuan Wang, Xing Zhang, Feng Gao, Yajing Wang, Yulin Li, Shengpeng Wang, Ling Tao, Wenjun Yan   +19 more
wiley   +1 more source