Results 221 to 230 of about 641,320 (378)

A Dynamic Gate Enables Regioselective Hydroxylation of Free Arginine by a Non‐Canonical Heme Enzyme

Advanced Science, EarlyView.
The YqcI/YcgG enzyme AglA employs a unique “sandwich” fold and a dynamic gating mechanism to selectively hydroxylate AMPn‐Arg at Nε. Site‐directed mutations reprogram regioselectivity or enable activity on free arginine by altering hydrogen‐bond networks, precisely positioning substrates.
Yuan Sun, Chao Dou, Weizhu Yan, Pengpeng Chen, Lu Zhang, Dan Zhou, Yanhui Zheng, Zhaolin Long, Shoujie Li, Xiaoqing Xu, Qiuxia Huang, Xiaofeng Zhu, Wei Cheng   +12 more
wiley   +1 more source

Mongersen, an oral SMAD7 antisense oligonucleotide, and Crohn's disease.

New England Journal of Medicine, 2015
G. Monteleone, M. Neurath, S. Ardizzone, A. Di Sabatino, M. Fantini, F. Castiglione, M. Scribano, A. Armuzzi, F. Caprioli, G. Sturniolo, F. Rogai, M. Vecchi, R. Atreya, F. Bossa, S. Onali, M. Fichera, G. Corazza, L. Biancone, V. Savarino, R. Pica, A. Orlando, F. Pallone   +21 more
semanticscholar   +1 more source

Oligonucleotide Therapies for the Lung: Ready to Return to the Clinic? [PDF]

, 2017
Manish Kumar, Sterghios Moschos
openalex   +1 more source

Supplemental Figure 4 from Generation 2.5 Antisense Oligonucleotides Targeting the Androgen Receptor and Its Splice Variants Suppress Enzalutamide-Resistant Prostate Cancer Cell Growth

, 2023
Yoshiaki Yamamoto, Yohann Loriot, Eliana Beraldi, Fan Zhang, Alexander W. Wyatt, Nader Al Nakouzi, Fan Mo, Tianyuan Zhou, Young Soo Kim, Brett P. Monia, A. Robert MacLeod, Ladan Fazli, Yuzhuo Wang, Colin C. Collins, Amina Zoubeidi, Martin Gleave   +15 more
openalex   +1 more source

GLUL Confers Perivascular Cancer‐Associated Fibroblasts With Pro‐Angiogenic Capacity to Promote Glioma Progression

Advanced Science, EarlyView.
Schematic illustration of the proposed model. Primary CAFs are isolated from fresh human GBM specimens according to established protocols. GLUL is essential for pro‐angiogenic capacity of CAFs through its impact on the PI3K/AKT pathway. GLUL enhances the pro‐angiogenic capacity of CAFs, driving aberrant tumor vasculature that fuels tumor growth ...
Qing Zhang, Yida Liu, Zhi Zhang, Yang Wang, Fusheng Liu   +4 more
wiley   +1 more source

Application of a suite of 16S rRNA-specific oligonucleotide probes designed to investigate bacteria of the phylum cytophaga-flavobacter-bacteroides in the natural environment.

Microbiology, 1996
W. Manz, R. Amann, W. Ludwig, M. Vancanneyt, K. Schleifer   +4 more
semanticscholar   +1 more source

Comparative Evaluation of Antibody-Oligonucleotide Conjugation Strategies for Multiplexed Imaging Applications. [PDF]

Lab Invest
Caraccio C, van de Klashorst J, Cherkas S, Ancel S, Kempchen TN, Vazquez G, Goltsev Y, Wang YX, Nolan GP, Hickey JW.   +9 more
europepmc   +1 more source

Organization of the AKR Qa region [PDF]

, 1989
Bevec, Dorian, Grosshaus, C., Messer, Gerald, Schmidt, Walter, Schwemmle, Sabine, Steinmetz, M., Weiss, Elisabeth H.   +6 more
core   +1 more source

Targeted Intracellular Delivery of Antisense Oligonucleotides via Conjugation with Small-Molecule Ligands

, 2010
Osamu Nakagawa, Xin Ming, Leaf Huang, Rudolph L. Juliano   +3 more
openalex   +2 more sources

Figure S3 from Radiotherapy Combined with Novel STING-Targeting Oligonucleotides Results in Regression of Established Tumors

, 2023
Jason R. Baird, David S. Friedman, Benjamin Cottam, Thomas W. Dubensky, David B. Kanne, Shelly Bambina, Keith S. Bahjat, Marka R. Crittenden, Michael J. Gough   +8 more
openalex   +1 more source