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Carbohydrate‐Oligonucleotide Conjugates
Current Protocols in Nucleic Acid Chemistry, 2009AbstractThis unit describes a strategy for attaching two mannose and two galactose residues to an oligonucleotide. This conjugation can be performed at the 5′‐end of the oligonucleotide sequence, using modified phosphoramidites. First, the oligonucleotide scaffold is synthesized on solid support using a DNA synthesizer, with commercially available and ...
Gwladys, Pourceau +3 more
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Trichloroacetaldehyde modified oligonucleotides
Bioorganic & Medicinal Chemistry Letters, 2005Some commercial batches of dichloroacetic acid (DCA) contain traces of chloral (trichloroacetaldehyde). Using such DCA to effect detritylation during solid-phase oligonucleotide synthesis results in the formation of a family of process impurities in which the atoms of chloral (Cl3CCHO) are incorporated between the 5'-oxygen and phosphorus atoms of an ...
Hans, Gaus +7 more
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Targeting Therapeutic Oligonucleotides
New England Journal of Medicine, 2017Two recent studies test whether oligonucleotide drugs that are tailored to target different cell types — the hepatocyte and the myocyte and cardiomyocyte — actually target those cell types.
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Diagnosis with oligonucleotides
Clinics in Dermatology, 1991Abstract Protein-based immunohistochemical techniques like immunoperoxidase methods are now routinely used in many diagnostic dermatopathology laboratories. This is possible because of the availability of antibodies that react with specific, diagnostically useful proteins and because there are simple but sensitive detection systems.
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Synthesis of Oligonucleotides and Oligonucleotide Analogues
1989The aim of this review is to outline modern methods for synthesizing natural oligodeoxynucleotides and certain analogues that may be inhibitors of gene expression. As a consequence, several DNA chemical synthesis methodologies such as the phosphate diester and phosphate triester approaches, which are now primarily only of historical interest, will not ...
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