Results 21 to 30 of about 629,663 (337)

Identification of candidate regulatory sequences in mammalian 3' UTRs by statistical analysis of oligonucleotide distributions [PDF]

, 2007
3' untranslated regions (3' UTRs) contain binding sites for many regulatory elements, and in particular for microRNAs (miRNAs). The importance of miRNA-mediated post-transcriptional regulation has become increasingly clear in the last few years.
Caselle, Michele, Cora, Davide, Di Cunto, Ferdinando, Provero, Paolo   +3 more
core   +4 more sources

Digital modeling by biomedical informatics analysis predicts suppression of COVID-19 infectivity via ‘targeting oligonucleotide-directed devolution’ [PDF]

Exploration of Digital Health Technologies
Aim: Genetic instability represents the hallmark of carcinogenesis. For cancer, the retinoblastoma (RB) gene defect allowing genetic instability was successfully exploited to eliminate cancer.
Frank-Un Hong, Miguel Marciano Castro, Klaus D. Linse   +2 more
doaj   +1 more source

Rapid generation of chromosome-specific alphoid DNA probes using the polymerase chain reaction [PDF]

, 1992
Non-isotopic in situ hybridization of chromosome-specific alphoid DNA probes has become a potent tool in the study of numerical aberrations of specific human chromosomes at all stages of the cell cycle. In this paper, we describe approaches for the rapid
A Gnirke, AHN Hopman, AR Mitchell, C Huxley, C Lengauer, Christoph Lengauer, D Pinkel, ED Green, EW Jabs, HF Willard, HF Willard, HF Willard, HM Rosenberg, Ian Dunham, J Anastasi, J Meyne, JE Koch, JS Waye, JS Waye, JS Waye, L Manuelidis, L Manuelidis, M Klever, P Emmerich, PJ Poddighe, PR Langer, S Popp, T Cremer, T Cremer, T Cremer, T Imai, T Maniatis, Terry Featherstone, Thomas Cremer   +33 more
core   +1 more source

PK-modifying anchors significantly alter clearance kinetics, tissue distribution, and efficacy of therapeutics siRNAs

Molecular Therapy: Nucleic Acids, 2022
Effective systemic delivery of small interfering RNAs (siRNAs) to tissues other than liver remains a challenge. siRNAs are small (∼15 kDa) and therefore rapidly cleared by the kidneys, resulting in limited blood residence times and tissue exposure ...
Bruno M.D.C. Godinho, Emily G. Knox, Samuel Hildebrand, James W. Gilbert, Dimas Echeverria, Zachary Kennedy, Reka A. Haraszti, Chantal M. Ferguson, Andrew H. Coles, Annabelle Biscans, Jillian Caiazzi, Julia F. Alterman, Matthew R. Hassler, Anastasia Khvorova   +13 more
doaj   +1 more source

Detection of minority variants within bovine respiratory syncytial virus populations using oligonucleotide-based microarrays [PDF]

, 2008
Microarray technology, originally developed for highly parallel examination of gene expression is regarded as a potential tool in prognosis and diagnosis.
Baranowski, Eric, Deplanche, Martine, François, Jean Marie, Leberre, Véronique, Trouilh, Lidwine   +4 more
core   +2 more sources

Watching the hands of the Arabidopsis biological clock [PDF]

, 2001
Oligonucleotide and cDNA microarrays have been used to analyse the mRNA levels of 8,000 genes in Arabidopsis thaliana throughout the day/night cycle. Genes involved in signal transduction and in various metabolic pathways were found to be coordinately ...
Davis, Seth J., Millar, A. J. (Andrew J.)   +1 more
core   +2 more sources

Non-Nucleosidic Analogues of Polyaminonucleosides and Their Influence on Thermodynamic Properties of Derived Oligonucleotides

Molecules, 2015
The rationale for the synthesis of cationic modified nucleosides is higher expected nuclease resistance and potentially better cellular uptake due to an overall reduced negative charge based on internal charge compensation.
Jolanta Brzezinska, Wojciech T. Markiewicz   +1 more
doaj   +1 more source

Dendrimer Anion-Exchange Stationary Phase for Separation of Oligonucleotides

Molecules, 2022
Oligonucleotides are used in many research areas. Thus, there is a need for their successful separation methods. Ion-exchange chromatography is the most popular separation technique, but it has limitations for these compounds.
Sylwia Studzińska, Szymon Bocian, Anna Kilanowska, Bogusław Buszewski   +3 more
doaj   +1 more source

Evaluation of chronic lymphocytic leukemia by oligonucleotide-based microarray analysis uncovers novel aberrations not detected by FISH or cytogenetic analysis

Molecular Cytogenetics, 2011
Background Cytogenetic evaluation is a key component of the diagnosis and prognosis of chronic lymphocytic leukemia (CLL). We performed oligonucleotide-based comparative genomic hybridization microarray analysis on 34 samples with CLL and known abnormal ...
Kolquist Kathryn A, Schultz Roger A, Slovak Marilyn L, McDaniel Lisa D, Brown Theresa C, Tubbs Raymond R, Cook James R, Theil Karl S, Cawich Victoria, Valentin Caitlin, Minier Sara, Neill Nicholas J, Byerly Steve, Morton S, Sahoo Trilochan, Ballif Blake C, Shaffer Lisa G   +16 more
doaj   +1 more source

Oligonucleotides-Based Therapeutics [PDF]

Biomedicines, 2021
This Special Issue of Biomedicines aims to outline nucleic-acid-based strategies that have emerged as tools to regulate specific gene expression and, more recently, as a new class of medicines [...]
openaire   +3 more sources