Results 21 to 30 of about 631,998 (390)
Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection.
Proceedings of the National Academy of Sciences of the United States of America, 2001 Recent advances in cDNA and oligonucleotide DNA arrays have made it possible to measure the abundance of mRNA transcripts for many genes simultaneously.
Cheng Li, W. Wong
semanticscholar +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 1988 We have devised a simple and efficient cDNA cloning strategy that overcomes many of the difficulties encountered in obtaining full-length cDNA clones of low-abundance mRNAs.
M. Frohman, M. Dush, G. Martin
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, 2010 Superparamagnetic iron oxide nanometre scale particles have been utilised as contrast agents to image staked target binding oligonucleotide arrays using MRI to correlate the signal intensity and relaxation times in different NMR ...
Bencsik, Martin +6 more
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Pharmaceuticals, 2018 It is well known that unmethylated 2′-deoxycytidine-phosphate-2′-guanine (CpG) sequences alone or in longer DNA and RNA oligonucleotides can act like pathogen-associated molecular patterns (PAMPs) and trigger the innate immune response ...
John G. Bruno
doaj +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 1995 Several polycations possessing substantial buffering capacity below physiological pH, such as lipopolyamines and polyamidoamine polymers, are efficient transfection agents per se--i.e., without the addition of cell targeting or membrane-disruption agents.
O. Boussif +6 more
semanticscholar +1 more source
Application of chicken microarrays for gene expression analysis in other avian species [PDF]
, 2009 BACKGROUND: With the threat of emerging infectious diseases such as avian influenza, whose natural hosts are thought to be a variety of wild water birds including duck, we are armed with very few genomic resources to investigate large scale immunological
Burggraaf, Simon +3 more
core +2 more sources
SOAP: short oligonucleotide alignment program
Bioinform., 2008 SUMMARY We have developed a program SOAP for efficient gapped and ungapped alignment of short oligonucleotides onto reference sequences. The program is designed to handle the huge amounts of short reads generated by parallel sequencing using the new ...
Ruiqiang Li +3 more
semanticscholar +1 more source
Diarylethene-modified nucleotides for switching optical properties in DNA
Beilstein Journal of Organic Chemistry, 2012 Diarylethenes were attached to the 5-position of 2’-deoxyuridine in order to yield three different photochromic nucleosides. All nucleosides were characterized with respect to their absorption and photochromic properties. Based on these results, the most
Sebastian Barrois +1 more
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Oligonucleotides-Based Therapeutics [PDF]
Biomedicines, 2021 This Special Issue of Biomedicines aims to outline nucleic-acid-based strategies that have emerged as tools to regulate specific gene expression and, more recently, as a new class of medicines [...]
openaire +3 more sources
Investigating synthetic oligonucleotide targeting of miR31 in Duchenne muscular dystrophy [PDF]
, 2016 Exon-skipping via synthetic antisense oligonucleotides represents one of the most promising potential therapies for Duchenne muscular dystrophy (DMD), yet this approach is highly sequence-specific and thus each oligonucleotide is of benefit to only a ...
Hildyard, J C W, Wells, D J
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