Results 21 to 30 of about 413,466 (243)
Molecules, 2017 Antisense oligonucleotides (ASOs) conjugated to triantennary N-acetyl galactosamine (GalNAc) ligands represent an emerging approach to antisense therapy. Our current generation of GalNAc-ASO conjugates link the GalNAc to the 5′-terminus of the ASO.
Isaiah Cedillo +5 more
doaj +1 more source
Sensitive Silver-Enhanced Microplate Apta-Enzyme Assay of Sb3+ Ions in Drinking and Natural Waters
Molecules, 2023 The toxic effects of antimony pose risks to human health. Therefore, simple analytical techniques for its widescale monitoring in water sources are in demand. In this study, a sensitive microplate apta-enzyme assay for Sb3+ detection was developed.
Nadezhda S. Komova +4 more
doaj +1 more source
Dendrimer Anion-Exchange Stationary Phase for Separation of Oligonucleotides
Molecules, 2022 Oligonucleotides are used in many research areas. Thus, there is a need for their successful separation methods. Ion-exchange chromatography is the most popular separation technique, but it has limitations for these compounds.
Sylwia Studzińska +3 more
doaj +1 more source
Rapid and accurate synthesis of TALE genes from synthetic oligonucleotides
BioTechniques, 2016 Custom synthesis of transcription activator-like effector (TALE) genes has relied upon plasmid libraries of pre-fabricated TALE-repeat monomers or oligomers.
Fenghua Wang +6 more
doaj +1 more source
Delivery of Oligonucleotides: Efficiency with Lipid Conjugation and Clinical Outcome
Pharmaceutics, 2022 Oligonucleotides have shifted drug discovery into a new paradigm due to their ability to silence the genes and inhibit protein translation. Importantly, they can drug the un-druggable targets from the conventional small-molecule perspective ...
Phuc Tran +3 more
doaj +1 more source
Molecules, 2017 Oligonucleotide (ON) drugs, including small interfering RNA (siRNA), microRNA (miRNA) and antisense oligonucleotides, are promising therapeutic agents.
Yating Sun +5 more
doaj +1 more source
Exosomes in Cardiovascular Disease: From Mechanism to Therapeutic Target
Metabolites, 2023 Cardiovascular disease (CVD) is the leading cause of morbidity and mortality globally. In recent decades, clinical research has made significant advances, resulting in improved survival and recovery rates for patients with CVD.
Allison B. Reiss +4 more
doaj +1 more source
Molecular Therapy: Nucleic Acids, 2022 Effective systemic delivery of small interfering RNAs (siRNAs) to tissues other than liver remains a challenge. siRNAs are small (∼15 kDa) and therefore rapidly cleared by the kidneys, resulting in limited blood residence times and tissue exposure ...
Bruno M.D.C. Godinho +13 more
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Pharmaceuticals, 2018 It is well known that unmethylated 2′-deoxycytidine-phosphate-2′-guanine (CpG) sequences alone or in longer DNA and RNA oligonucleotides can act like pathogen-associated molecular patterns (PAMPs) and trigger the innate immune response ...
John G. Bruno
doaj +1 more source
Oligonucleotides-Based Therapeutics [PDF]
Biomedicines, 2021 This Special Issue of Biomedicines aims to outline nucleic-acid-based strategies that have emerged as tools to regulate specific gene expression and, more recently, as a new class of medicines [...]
openaire +3 more sources