Results 21 to 30 of about 641,320 (378)

Investigating synthetic oligonucleotide targeting of miR31 in Duchenne muscular dystrophy [PDF]

, 2016
Exon-skipping via synthetic antisense oligonucleotides represents one of the most promising potential therapies for Duchenne muscular dystrophy (DMD), yet this approach is highly sequence-specific and thus each oligonucleotide is of benefit to only a ...
Hildyard, J C W, Wells, D J
core   +1 more source

Chemically Modified Oligonucleotides Modulate an Epigenetically Varied and Transient Form of Transcription Silencing of HIV-1 in Human Cells

Molecular Therapy: Nucleic Acids, 2012
Small noncoding RNAs (ncRNAs) have been shown to guide epigenetic silencing complexes to target loci in human cells. When targeted to gene promoters, these small RNAs can lead to long-term stable epigenetic silencing of gene transcription. To date, small
Stuart Knowling, Kenneth Stapleton, Anne-Marie W Turner, Eugen Uhlmann, Thomas Lehmann, Jörg Vollmer, Kevin V Morris   +6 more
doaj   +1 more source

Watching the hands of the Arabidopsis biological clock [PDF]

, 2001
Oligonucleotide and cDNA microarrays have been used to analyse the mRNA levels of 8,000 genes in Arabidopsis thaliana throughout the day/night cycle. Genes involved in signal transduction and in various metabolic pathways were found to be coordinately ...
Davis, Seth J., Millar, A. J. (Andrew J.)   +1 more
core   +3 more sources

Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing

Journal of Organic Chemistry, 2020
With a renewed and growing interest in therapeutic oligonucleotides across the pharmaceutical industry, pressure is increasing on drug developers to take more seriously the sustainability ramifications of this modality.
Benjamin I. Andrews, F. Antia, Shawn B. Brueggemeier, L. Diorazio, S. Koenig, M. Kopach, Heewon Lee, M. Olbrich, A. Watson   +8 more
semanticscholar   +1 more source

Evaluation of chronic lymphocytic leukemia by oligonucleotide-based microarray analysis uncovers novel aberrations not detected by FISH or cytogenetic analysis

Molecular Cytogenetics, 2011
Background Cytogenetic evaluation is a key component of the diagnosis and prognosis of chronic lymphocytic leukemia (CLL). We performed oligonucleotide-based comparative genomic hybridization microarray analysis on 34 samples with CLL and known abnormal ...
Kolquist Kathryn A, Schultz Roger A, Slovak Marilyn L, McDaniel Lisa D, Brown Theresa C, Tubbs Raymond R, Cook James R, Theil Karl S, Cawich Victoria, Valentin Caitlin, Minier Sara, Neill Nicholas J, Byerly Steve, Morton S, Sahoo Trilochan, Ballif Blake C, Shaffer Lisa G   +16 more
doaj   +1 more source

Detection of minority variants within bovine respiratory syncytial virus populations using oligonucleotide-based microarrays [PDF]

, 2008
Microarray technology, originally developed for highly parallel examination of gene expression is regarded as a potential tool in prognosis and diagnosis.
Baranowski, Eric, Deplanche, Martine, François, Jean Marie, Leberre, Véronique, Trouilh, Lidwine   +4 more
core   +3 more sources

Synthesis of 5′-GalNAc-Conjugated Oligonucleotides: A Comparison of Solid and Solution-Phase Conjugation Strategies

Molecules, 2017
Antisense oligonucleotides (ASOs) conjugated to triantennary N-acetyl galactosamine (GalNAc) ligands represent an emerging approach to antisense therapy. Our current generation of GalNAc-ASO conjugates link the GalNAc to the 5′-terminus of the ASO.
Isaiah Cedillo, Dana Chreng, Elyse Engle, Lijian Chen, Andrew K. McPherson, Andrew A. Rodriguez   +5 more
doaj   +1 more source

DNA Data Storage

BioTech, 2023
The demand for data storage is growing at an unprecedented rate, and current methods are not sufficient to accommodate such rapid growth due to their cost, space requirements, and energy consumption.
Tomasz Buko, Nella Tuczko, Takao Ishikawa   +2 more
doaj   +1 more source

Detection and characterization of Sp1 binding activity in human chondrocytes and its alterations during chondrocyte dedifferentiation. [PDF]

, 1997
We have detected DNA binding activity for a synthetic oligonucleotide containing an Sp1 consensus sequence in nuclear extracts from human chondrocytes. Changes in the levels of Sp1 oligonucleotide binding activity were examined in nuclear extracts from ...
Dharmavaram, Rita M., Jimenez, Sergio A., Liu, Gang, Mowers, Sheryl D.   +3 more
core   +2 more sources

Polymer–Colloid Complexes Based on Cationic Imidazolium Amphiphile, Polyacrylic Acid and DNA Decamer

Molecules, 2021
The solution behavior and physicochemical characteristics of polymer–colloid complexes based on cationic imidazolium amphiphile with a dodecyl tail (IA-12) and polyacrylic acid (PAA) or DNA decamer (oligonucleotide) were evaluated using tensiometry ...
Darya A. Kuznetsova, Dinar R. Gabdrakhmanov, Denis M. Kuznetsov, Svetlana S. Lukashenko, Valery M. Zakharov, Anastasiia S. Sapunova, Syumbelya K. Amerhanova, Anna P. Lyubina, Alexandra D. Voloshina, Diana V. Salakhieva, Lucia Ya. Zakharova   +10 more
doaj   +1 more source