Results 41 to 50 of about 732,131 (343)
Rapid and accurate synthesis of TALE genes from synthetic oligonucleotides
BioTechniques, 2016 Custom synthesis of transcription activator-like effector (TALE) genes has relied upon plasmid libraries of pre-fabricated TALE-repeat monomers or oligomers.
Fenghua Wang +6 more
doaj +1 more source
Application of COMPOCHIP Microarray to Investigate the Bacterial Communities of Different Composts [PDF]
, 2009 A microarray spotted with 369 different 16S rRNA gene probes specific to microorganisms involved in the degradation process of organic waste during composting was developed. The microarray was tested with pure cultures, and of the 30,258 individual probe-
A Alfreider +54 more
core +1 more source
A new subfamily of fungal subtilases: structural and functional analysis of a Pleurotus ostreatus member [PDF]
, 2005 Pleurotus ostreatus produces several extracellular proteases which are believed to be involved in the regulation of the ligninolytic activities of this fungus. Recently, purification and characterization of the most abundant P.
FARACO, VINCENZA +5 more
core +2 more sources
Patient-Customized Oligonucleotide Therapy for a Rare Genetic Disease.
New England Journal of Medicine, 2019 Genome sequencing is often pivotal in the diagnosis of rare diseases, but many of these conditions lack specific treatments. We describe how molecular diagnosis of a rare, fatal neurodegenerative condition led to the rational design, testing, and ...
Jinkuk Kim +52 more
semanticscholar +1 more source
Phosphorothioate modified oligonucleotide–protein interactions
Nucleic Acids Research, 2020 Antisense oligonucleotides (ASOs) interact with target RNAs via hybridization to modulate gene expression through different mechanisms. ASO therapeutics are chemically modified and include phosphorothioate (PS) backbone modifications and different ribose
S. Crooke, T. Vickers, Xue-hai Liang
semanticscholar +1 more source
Delivery of Oligonucleotides: Efficiency with Lipid Conjugation and Clinical Outcome
Pharmaceutics, 2022 Oligonucleotides have shifted drug discovery into a new paradigm due to their ability to silence the genes and inhibit protein translation. Importantly, they can drug the un-druggable targets from the conventional small-molecule perspective ...
Phuc Tran +3 more
doaj +1 more source
Physico-chemical foundations underpinning microarray and next-generation sequencing experiments [PDF]
, 2013 Hybridization of nucleic acids on solid surfaces is a key process involved in high-throughput technologies such as microarrays and, in some cases, next-generation sequencing (NGS).
A. Buhot +70 more
core +3 more sources
Chemico-Biological Interactions, 2019 Oligonucleotide-based therapies are advanced novel interventions used in the management of various respiratory diseases such as asthma and Chronic Obstructive Pulmonary Disease (COPD).
M. Mehta +15 more
semanticscholar +1 more source
Molecules, 2017 Oligonucleotide (ON) drugs, including small interfering RNA (siRNA), microRNA (miRNA) and antisense oligonucleotides, are promising therapeutic agents.
Yating Sun +5 more
doaj +1 more source
Exosomes in Cardiovascular Disease: From Mechanism to Therapeutic Target
Metabolites, 2023 Cardiovascular disease (CVD) is the leading cause of morbidity and mortality globally. In recent decades, clinical research has made significant advances, resulting in improved survival and recovery rates for patients with CVD.
Allison B. Reiss +4 more
doaj +1 more source