Results 21 to 30 of about 732,131 (343)

Pharmacological Characterization of a Novel ENaCα siRNA (GSK2225745) With Potential for the Treatment of Cystic Fibrosis

Molecular Therapy: Nucleic Acids, 2013
Lung pathology in cystic fibrosis is linked to dehydration of the airways epithelial surface which in part results from inappropriately raised sodium reabsorption through the epithelial sodium channel (ENaC).
Kenneth L Clark, Stephen A Hughes, Pallav Bulsara, Jill Coates, Kitty Moores, Joel Parry, Michael Carr, Ruth J Mayer, Paul Wilson, Chris Gruenloh, Daren Levin, Jill Darton, Wolf-Michael Weber, Katja Sobczak, Deborah R Gill, Stephen C Hyde, Lee A Davies, Ian A Pringle, Stephanie G Sumner-Jones, Vasant Jadhav, Sharon Jamison, Walter R Strapps, Victoria Pickering, Mark R Edbrooke   +23 more
doaj   +1 more source

Oligonucleotide-capped nanoporous anodic alumina biosensor as diagnostic tool for rapid and accurate detection of Candida auris in clinical samples

Emerging Microbes and Infections, 2021
Candida auris has arisen as an important multidrug-resistant fungus because of several nosocomial outbreaks and elevated rates of mortality. Accurate and rapid diagnosis of C.
Luis Pla, Sara Santiago-Felipe, María Ángeles Tormo-Mas, Alba Ruiz-Gaitán, Javier Pemán, Eulogio Valentín, Félix Sancenón, Elena Aznar, Ramón Martínez-Máñez   +8 more
doaj   +1 more source

Towards MRI microarrays [PDF]

, 2010
Superparamagnetic iron oxide nanometre scale particles have been utilised as contrast agents to image staked target binding oligonucleotide arrays using MRI to correlate the signal intensity and relaxation times in different NMR ...
Bencsik, Martin, Blanco-Andujar, Cristina, Cave, Gareth, Hall, Andrew, McHale, Glen, Mundell, Victoria, Newton, Michael   +6 more
core   +1 more source

Chemically Modified Oligonucleotides Modulate an Epigenetically Varied and Transient Form of Transcription Silencing of HIV-1 in Human Cells

Molecular Therapy: Nucleic Acids, 2012
Small noncoding RNAs (ncRNAs) have been shown to guide epigenetic silencing complexes to target loci in human cells. When targeted to gene promoters, these small RNAs can lead to long-term stable epigenetic silencing of gene transcription. To date, small
Stuart Knowling, Kenneth Stapleton, Anne-Marie W Turner, Eugen Uhlmann, Thomas Lehmann, Jörg Vollmer, Kevin V Morris   +6 more
doaj   +1 more source

Rapid generation of chromosome-specific alphoid DNA probes using the polymerase chain reaction [PDF]

, 1992
Non-isotopic in situ hybridization of chromosome-specific alphoid DNA probes has become a potent tool in the study of numerical aberrations of specific human chromosomes at all stages of the cell cycle. In this paper, we describe approaches for the rapid
A Gnirke, AHN Hopman, AR Mitchell, C Huxley, C Lengauer, Christoph Lengauer, D Pinkel, ED Green, EW Jabs, HF Willard, HF Willard, HF Willard, HM Rosenberg, Ian Dunham, J Anastasi, J Meyne, JE Koch, JS Waye, JS Waye, JS Waye, L Manuelidis, L Manuelidis, M Klever, P Emmerich, PJ Poddighe, PR Langer, S Popp, T Cremer, T Cremer, T Cremer, T Imai, T Maniatis, Terry Featherstone, Thomas Cremer   +33 more
core   +1 more source

Conformational profiling of a G-rich sequence within the c-KIT promoter [PDF]

, 2017
G-quadruplexes (G4) within oncogene promoters are considered to be promising anticancer targets. However, often they undergo complex structural rearrangements that preclude a precise description of the optimal target.
Chaires, Jonathan B, Dean, William L, Gray, Robert D, Rigo, Riccardo, Sissi, Claudia   +4 more
core   +1 more source

Digital modeling by biomedical informatics analysis predicts suppression of COVID-19 infectivity via ‘targeting oligonucleotide-directed devolution’ [PDF]

Exploration of Digital Health Technologies
Aim: Genetic instability represents the hallmark of carcinogenesis. For cancer, the retinoblastoma (RB) gene defect allowing genetic instability was successfully exploited to eliminate cancer.
Frank-Un Hong, Miguel Marciano Castro, Klaus D. Linse   +2 more
doaj   +1 more source

Recent Advances in Oligonucleotide Therapeutics in Oncology

International Journal of Molecular Sciences, 2021
Cancer is one of the leading causes of death worldwide. Conventional therapies, including surgery, radiation, and chemotherapy have achieved increased survival rates for many types of cancer over the past decades.
Haoyu Xiong, R. Veedu, Sarah D. Diermeier   +2 more
semanticscholar   +1 more source

Detection of minority variants within bovine respiratory syncytial virus populations using oligonucleotide-based microarrays [PDF]

, 2008
Microarray technology, originally developed for highly parallel examination of gene expression is regarded as a potential tool in prognosis and diagnosis.
Baranowski, Eric, Deplanche, Martine, François, Jean Marie, Leberre, Véronique, Trouilh, Lidwine   +4 more
core   +3 more sources

DNA Data Storage

BioTech, 2023
The demand for data storage is growing at an unprecedented rate, and current methods are not sufficient to accommodate such rapid growth due to their cost, space requirements, and energy consumption.
Tomasz Buko, Nella Tuczko, Takao Ishikawa   +2 more
doaj   +1 more source