Results 31 to 40 of about 732,131 (343)

Non-Nucleosidic Analogues of Polyaminonucleosides and Their Influence on Thermodynamic Properties of Derived Oligonucleotides

Molecules, 2015
The rationale for the synthesis of cationic modified nucleosides is higher expected nuclease resistance and potentially better cellular uptake due to an overall reduced negative charge based on internal charge compensation.
Jolanta Brzezinska, Wojciech T. Markiewicz   +1 more
doaj   +1 more source

Polymer–Colloid Complexes Based on Cationic Imidazolium Amphiphile, Polyacrylic Acid and DNA Decamer

Molecules, 2021
The solution behavior and physicochemical characteristics of polymer–colloid complexes based on cationic imidazolium amphiphile with a dodecyl tail (IA-12) and polyacrylic acid (PAA) or DNA decamer (oligonucleotide) were evaluated using tensiometry ...
Darya A. Kuznetsova, Dinar R. Gabdrakhmanov, Denis M. Kuznetsov, Svetlana S. Lukashenko, Valery M. Zakharov, Anastasiia S. Sapunova, Syumbelya K. Amerhanova, Anna P. Lyubina, Alexandra D. Voloshina, Diana V. Salakhieva, Lucia Ya. Zakharova   +10 more
doaj   +1 more source

pH-Sensitive Chitosan–Heparin Nanoparticles for Effective Delivery of Genetic Drugs into Epithelial Cells [PDF]

, 2019
Chitosan has been extensively studied as a genetic drug delivery platform. However, its efficiency is limited by the strength of DNA and RNA binding.
Korzhikov-Vlakh, Viktor, Pilipenko, Iuliia, Rühl, Eckart, Schäfer-Korting, Monika, Sharoyko, Vladimir, Tennikova, Tatiana, Zhang, Nan, Zoschke, Christian   +7 more
core   +1 more source

Evaluation of chronic lymphocytic leukemia by oligonucleotide-based microarray analysis uncovers novel aberrations not detected by FISH or cytogenetic analysis

Molecular Cytogenetics, 2011
Background Cytogenetic evaluation is a key component of the diagnosis and prognosis of chronic lymphocytic leukemia (CLL). We performed oligonucleotide-based comparative genomic hybridization microarray analysis on 34 samples with CLL and known abnormal ...
Kolquist Kathryn A, Schultz Roger A, Slovak Marilyn L, McDaniel Lisa D, Brown Theresa C, Tubbs Raymond R, Cook James R, Theil Karl S, Cawich Victoria, Valentin Caitlin, Minier Sara, Neill Nicholas J, Byerly Steve, Morton S, Sahoo Trilochan, Ballif Blake C, Shaffer Lisa G   +16 more
doaj   +1 more source

Locked nucleic acid: tighter is different [PDF]

, 2013
This viewpoint briefly reviews the impact of Locked Nucleic Acid (LNA) oligonucleotides, first described in a ChemComm paper in 1998. A number of unique applications in oligonucleotide biotechnology have been made possible by the high binding affinity ...
Watts, Jonathan
core   +1 more source

Synthesis of 5′-GalNAc-Conjugated Oligonucleotides: A Comparison of Solid and Solution-Phase Conjugation Strategies

Molecules, 2017
Antisense oligonucleotides (ASOs) conjugated to triantennary N-acetyl galactosamine (GalNAc) ligands represent an emerging approach to antisense therapy. Our current generation of GalNAc-ASO conjugates link the GalNAc to the 5′-terminus of the ASO.
Isaiah Cedillo, Dana Chreng, Elyse Engle, Lijian Chen, Andrew K. McPherson, Andrew A. Rodriguez   +5 more
doaj   +1 more source

Sensitive Silver-Enhanced Microplate Apta-Enzyme Assay of Sb³⁺ Ions in Drinking and Natural Waters

Molecules, 2023
The toxic effects of antimony pose risks to human health. Therefore, simple analytical techniques for its widescale monitoring in water sources are in demand. In this study, a sensitive microplate apta-enzyme assay for Sb3+ detection was developed.
Nadezhda S. Komova, Kseniya V. Serebrennikova, Anna N. Berlina, Anatoly V. Zherdev, Boris B. Dzantiev   +4 more
doaj   +1 more source

Developmental and tissue-specific expression of the Q5k gene [PDF]

, 1991
Expression of the Q5k gene was examined by northern blot analysis and polymerase chain reaction (PCR) in the AKR mouse and various cell lines, each of the H-2k haplotype.
Baeuerle, Patrick A., Bevec, Dorian, Brem, Gottfried, Schwemmle, Sabine, Urban, Manuela B., Weiss, Elisabeth H.   +5 more
core   +1 more source

Dendrimer Anion-Exchange Stationary Phase for Separation of Oligonucleotides

Molecules, 2022
Oligonucleotides are used in many research areas. Thus, there is a need for their successful separation methods. Ion-exchange chromatography is the most popular separation technique, but it has limitations for these compounds.
Sylwia Studzińska, Szymon Bocian, Anna Kilanowska, Bogusław Buszewski   +3 more
doaj   +1 more source

Electrochemical detection of the toxic dinoflagellate Alexandrium ostenfeldii with a DNA-biosensor [PDF]

, 2005
The steady rise of observations of harmful or toxic algal blooms throughout the world in the past decades constitute a menace for coastal ecosystems and human interests.
Huljic, S., Lange, M., Medlin, Linda, Metfies, Katja   +3 more
core   +1 more source