Results 31 to 40 of about 635,743 (331)
Delivery of Oligonucleotides: Efficiency with Lipid Conjugation and Clinical Outcome
Pharmaceutics, 2022 Oligonucleotides have shifted drug discovery into a new paradigm due to their ability to silence the genes and inhibit protein translation. Importantly, they can drug the un-druggable targets from the conventional small-molecule perspective ...
Phuc Tran +3 more
doaj +1 more source
Conformational profiling of a G-rich sequence within the c-KIT promoter [PDF]
, 2017 G-quadruplexes (G4) within oncogene promoters are considered to be promising anticancer targets. However, often they undergo complex structural rearrangements that preclude a precise description of the optimal target.
Chaires, Jonathan B +4 more
core +1 more source
Exosomes in Cardiovascular Disease: From Mechanism to Therapeutic Target
Metabolites, 2023 Cardiovascular disease (CVD) is the leading cause of morbidity and mortality globally. In recent decades, clinical research has made significant advances, resulting in improved survival and recovery rates for patients with CVD.
Allison B. Reiss +4 more
doaj +1 more source
A cellulose-based bioassay for the colorimetric detection of pathogen DNA [PDF]
, 2014 Cellulose-paper-based colorimetric bioassays may be used at the point of sampling without sophisticated equipment. This study reports the development of a colorimetric bioassay based on cellulose that can detect pathogen DNA.
Goyal, Madhu +3 more
core +1 more source
Molecular Therapy: Nucleic Acids, 2022 Effective systemic delivery of small interfering RNAs (siRNAs) to tissues other than liver remains a challenge. siRNAs are small (∼15 kDa) and therefore rapidly cleared by the kidneys, resulting in limited blood residence times and tissue exposure ...
Bruno M.D.C. Godinho +13 more
doaj +1 more source
pH-Sensitive Chitosan–Heparin Nanoparticles for Effective Delivery of Genetic Drugs into Epithelial Cells [PDF]
, 2019 Chitosan has been extensively studied as a genetic drug delivery platform. However, its efficiency is limited by the strength of DNA and RNA binding.
Korzhikov-Vlakh, Viktor +7 more
core +1 more source
Diarylethene-modified nucleotides for switching optical properties in DNA
Beilstein Journal of Organic Chemistry, 2012 Diarylethenes were attached to the 5-position of 2’-deoxyuridine in order to yield three different photochromic nucleosides. All nucleosides were characterized with respect to their absorption and photochromic properties. Based on these results, the most
Sebastian Barrois +1 more
doaj +1 more source
Improved Lower Bounds for Constant GC-Content DNA Codes
, 2008 The design of large libraries of oligonucleotides having constant GC-content and satisfying Hamming distance constraints between oligonucleotides and their Watson-Crick complements is important in reducing hybridization errors in DNA computing, DNA ...
Chee, Yeow Meng, Ling, San
core +2 more sources
In vivo delivery of transcription factors with multifunctional oligonucleotides. [PDF]
, 2015 Therapeutics based on transcription factors have the potential to revolutionize medicine but have had limited clinical success as a consequence of delivery problems. The delivery of transcription factors is challenging because it requires the development
Aran, Kiana +9 more
core +3 more sources
Tissue pharmacokinetics of antisense oligonucleotides
Molecular Therapy: Nucleic AcidsPharmacokinetics (PK) of antisense oligonucleotides (ASOs) is characterized by rapid distribution from plasma to tissue and slow terminal plasma elimination driven by re-distribution from tissue.
Erica Bäckström +7 more
doaj +1 more source