Results 31 to 40 of about 631,998 (390)

The role of SAXS and molecular simulations in 3D structure elucidation of a DNA aptamer against lung cancer

Molecular Therapy: Nucleic Acids, 2021
Aptamers are short, single-stranded DNA or RNA oligonucleotide molecules that function as synthetic analogs of antibodies and bind to a target molecule with high specificity.
Dmitry Morozov, Vladimir Mironov, Roman V. Moryachkov, Irina A. Shchugoreva, Polina V. Artyushenko, Galina S. Zamay, Olga S. Kolovskaya, Tatiana N. Zamay, Alexey V. Krat, Dmitry S. Molodenskiy, Vladimir N. Zabluda, Dmitry V. Veprintsev, Alexey E. Sokolov, Ruslan A. Zukov, Maxim V. Berezovski, Felix N. Tomilin, Dmitri G. Fedorov, Yuri Alexeev, Anna S. Kichkailo   +18 more
doaj  

Evaluation of chronic lymphocytic leukemia by oligonucleotide-based microarray analysis uncovers novel aberrations not detected by FISH or cytogenetic analysis

Molecular Cytogenetics, 2011
Background Cytogenetic evaluation is a key component of the diagnosis and prognosis of chronic lymphocytic leukemia (CLL). We performed oligonucleotide-based comparative genomic hybridization microarray analysis on 34 samples with CLL and known abnormal ...
Kolquist Kathryn A, Schultz Roger A, Slovak Marilyn L, McDaniel Lisa D, Brown Theresa C, Tubbs Raymond R, Cook James R, Theil Karl S, Cawich Victoria, Valentin Caitlin, Minier Sara, Neill Nicholas J, Byerly Steve, Morton S, Sahoo Trilochan, Ballif Blake C, Shaffer Lisa G   +16 more
doaj   +1 more source

A unified view of polymer, dumbbell, and oligonucleotide DNA nearest-neighbor thermodynamics.

Proceedings of the National Academy of Sciences of the United States of America, 1998
A unified view of polymer, dumbbell, and oligonucleotide nearest-neighbor (NN) thermodynamics is presented. DNA NN DeltaG degrees 37 parameters from seven laboratories are presented in the same format so that careful comparisons can be made.
Jr. John SantaLucia
semanticscholar   +1 more source

Rapid generation of chromosome-specific alphoid DNA probes using the polymerase chain reaction [PDF]

, 1992
Non-isotopic in situ hybridization of chromosome-specific alphoid DNA probes has become a potent tool in the study of numerical aberrations of specific human chromosomes at all stages of the cell cycle. In this paper, we describe approaches for the rapid
A Gnirke, AHN Hopman, AR Mitchell, C Huxley, C Lengauer, Christoph Lengauer, D Pinkel, ED Green, EW Jabs, HF Willard, HF Willard, HF Willard, HM Rosenberg, Ian Dunham, J Anastasi, J Meyne, JE Koch, JS Waye, JS Waye, JS Waye, L Manuelidis, L Manuelidis, M Klever, P Emmerich, PJ Poddighe, PR Langer, S Popp, T Cremer, T Cremer, T Cremer, T Imai, T Maniatis, Terry Featherstone, Thomas Cremer   +33 more
core   +1 more source

Non-Nucleosidic Analogues of Polyaminonucleosides and Their Influence on Thermodynamic Properties of Derived Oligonucleotides

Molecules, 2015
The rationale for the synthesis of cationic modified nucleosides is higher expected nuclease resistance and potentially better cellular uptake due to an overall reduced negative charge based on internal charge compensation.
Jolanta Brzezinska, Wojciech T. Markiewicz   +1 more
doaj   +1 more source

Antisense oligonucleotides for neurodegeneration [PDF]

Science, 2020
Promising clinical results for Huntington's disease give hope for other ...
Leavitt, BR, Tabrizi, SJ
openaire   +4 more sources

Identification of candidate regulatory sequences in mammalian 3' UTRs by statistical analysis of oligonucleotide distributions [PDF]

, 2007
3' untranslated regions (3' UTRs) contain binding sites for many regulatory elements, and in particular for microRNAs (miRNAs). The importance of miRNA-mediated post-transcriptional regulation has become increasingly clear in the last few years.
Caselle, Michele, Cora, Davide, Di Cunto, Ferdinando, Provero, Paolo   +3 more
core   +4 more sources

Synthesis of 5′-GalNAc-Conjugated Oligonucleotides: A Comparison of Solid and Solution-Phase Conjugation Strategies

Molecules, 2017
Antisense oligonucleotides (ASOs) conjugated to triantennary N-acetyl galactosamine (GalNAc) ligands represent an emerging approach to antisense therapy. Our current generation of GalNAc-ASO conjugates link the GalNAc to the 5′-terminus of the ASO.
Isaiah Cedillo, Dana Chreng, Elyse Engle, Lijian Chen, Andrew K. McPherson, Andrew A. Rodriguez   +5 more
doaj   +1 more source

Chromosome Painting Based on Bulked Oligonucleotides in Cotton

Frontiers in Plant Science, 2020
Chromosome painting is one of the key technologies in cytogenetic research, which can accurately identify chromosomes or chromosome regions. Oligonucleotide (oligo) probes designed based on genome sequences have both flexibility and specificity, which ...
Yuling Liu, Xiuyuan Wang, Yangyang Wei, Zhen Liu, Quanwei Lu, Fang Liu, Tao Zhang, Renhai Peng   +7 more
doaj   +1 more source

Molecular Chromophore-DNA Architectures With Fullerenes: Optical Properties and Solar Cells

Frontiers in Chemistry, 2021
Supramolecular chemistry allows the construction of complex molecular architectures and the design of collective photophysical properties. DNA is an attractive template to build such supramolecular architectures due to its helical structure, the defined ...
Sara Müller, Felix Manger, Felix Manger, Lorenz Graf von Reventlow, Lorenz Graf von Reventlow, Alexander Colsmann, Alexander Colsmann, Hans-Achim Wagenknecht   +7 more
doaj   +1 more source