Results 41 to 50 of about 631,998 (390)
Patient-Customized Oligonucleotide Therapy for a Rare Genetic Disease.
New England Journal of Medicine, 2019 Genome sequencing is often pivotal in the diagnosis of rare diseases, but many of these conditions lack specific treatments. We describe how molecular diagnosis of a rare, fatal neurodegenerative condition led to the rational design, testing, and ...
Jinkuk Kim +52 more
semanticscholar +1 more source
Phosphorothioate modified oligonucleotide–protein interactions
Nucleic Acids Research, 2020 Antisense oligonucleotides (ASOs) interact with target RNAs via hybridization to modulate gene expression through different mechanisms. ASO therapeutics are chemically modified and include phosphorothioate (PS) backbone modifications and different ribose
S. Crooke, T. Vickers, Xue-hai Liang
semanticscholar +1 more source
Antisense oligonucleotides [PDF]
Neurology Genetics, 2019 There are few disease-modifying therapeutics for neurodegenerative diseases, but successes on the development of antisense oligonucleotide (ASO) therapeutics for spinal muscular atrophy and Duchenne muscular dystrophy predict a robust future for ASOs in medicine.
Eric Vallabh Minikel +2 more
openaire +3 more sources
Detection of minority variants within bovine respiratory syncytial virus populations using oligonucleotide-based microarrays [PDF]
, 2008 Microarray technology, originally developed for highly parallel examination of gene expression is regarded as a potential tool in prognosis and diagnosis.
Baranowski, Eric +4 more
core +2 more sources
The legacy of mRNA engineering: A lineup of pioneers for the Nobel Prize
Molecular Therapy: Nucleic Acids, 2022 mRNA is like Hermes, delivering the genetic code to cellular construction sites, so it has long been of interest, but only to a small group of scientists, and only demonstrating its remarkable efficacy in coronavirus disease 2019 (COVID-19) vaccines ...
Miroslaw Janowski, Anna Andrzejewska
doaj
Synthesis of Unmodified Oligonucleotides [PDF]
Current Protocols in Nucleic Acid Chemistry, 2002 Peer Reviewed ; https://deepblue.lib.umich.edu/bitstream/2027.42/152987/1/cpnc0300 ...
openaire +5 more sources
Molecular Therapy: Nucleic Acids, 2023 Tumor suppressor genes (TSGs) are frequently downregulated in cancer, leading to dysregulation of the pathways that they control. The continuum model of tumor suppression suggests that even subtle changes in TSG expression, for example, driven by ...
Georgina L. Gregory, Ian M. Copple
doaj
Molecules, 2017 Oligonucleotide (ON) drugs, including small interfering RNA (siRNA), microRNA (miRNA) and antisense oligonucleotides, are promising therapeutic agents.
Yating Sun +5 more
doaj +1 more source
Watching the hands of the Arabidopsis biological clock [PDF]
, 2001 Oligonucleotide and cDNA microarrays have been used to analyse the mRNA levels of 8,000 genes in Arabidopsis thaliana throughout the day/night cycle. Genes involved in signal transduction and in various metabolic pathways were found to be coordinately ...
Davis, Seth J. +1 more
core +2 more sources
Rapid and accurate synthesis of TALE genes from synthetic oligonucleotides
BioTechniques, 2016 Custom synthesis of transcription activator-like effector (TALE) genes has relied upon plasmid libraries of pre-fabricated TALE-repeat monomers or oligomers.
Fenghua Wang +6 more
doaj +1 more source