Results 61 to 70 of about 641,320 (378)

Delivery of Gold Nanoparticles Inside Carbon Nanotubes by Oligonucleotides

Nano Biomedicine and Engineering, 2011
Delivery of gold nanoparticles with 2 nm or so in diameter inside multiwall carbon nanotubes (MCNTs) by oligonucleotides was performed under the condition of 400 k and 3 bar for 20 min.
Daxiang Cui, Cengiz S. Ozkan, Furong Tian, Yong Kong   +3 more
doaj   +1 more source

Error, reproducibility and sensitivity : a pipeline for data processing of Agilent oligonucleotide expression arrays [PDF]

, 2010
Background Expression microarrays are increasingly used to obtain large scale transcriptomic information on a wide range of biological samples. Nevertheless, there is still much debate on the best ways to process data, to design experiments and analyse ...
AR Dabney, AR Dabney, Benjamin Chain, BM Bolstad, BP Durbin, BS Everitt, CR Hampton, D Wang, E Birney, Helen Bowen, J Fan, J Rasaiyaah, J Rasaiyaah, Jane Rasaiyaah, Jhen Tsang, John Hammond, JP Hammond, L Shi, M Noursadeghi, M Sultan, Mahdad Noursadeghi, MN McCall, PA 't Hoen, TA Patterson, TC Kroll, WE Johnson, Wilfried Posch   +26 more
core   +2 more sources

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Recent advances in antisense oligonucleotide therapy in genetic neuromuscular diseases

Annals of Indian Academy of Neurology, 2018
Genetic neuromuscular diseases are caused by defective expression of nuclear or mitochondrial genes. Mutant genes may reduce expression of wild-type proteins, and strategies to activate expression of the wild-type proteins might provide therapeutic ...
Ashok Verma
doaj   +1 more source

Antivirals against HCV infection: the story thus far

Journal of Infection in Developing Countries, 2022
Remarkable scientific breakthroughs have been made in the stride towards the development of potent and tolerable hepatitis C regimens within the last three decades.
Ahmad Adebayo Irekeola, Engku Nur Syafirah EAR, Nur Amalin Zahirah Mohd Amin, Nazri Mustaffa, Rafidah Hanim Shueb   +4 more
doaj   +1 more source

Optimising the analysis of transcript data using high density oligonucleotide arrays and genomic DNA-based probe selection [PDF]

, 2007
Background: Affymetrix GeneChip arrays are widely used for transcriptomic studies in a diverse range of species. Each gene is represented on a GeneChip array by a probe-set, consisting of up to 16 probe-pairs. Signal intensities across probe-pairs within
Broadley, Martin R., Graham, Neil S., Hammond, John P., May, Sean T., White, Philip J.   +4 more
core   +4 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Interplay between RNA‐protein interactions and RNA structures in gene regulation

FEBS Open Bio, EarlyView.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko, Mauro Scaravilli, Minna‐Liisa Änkö   +2 more
wiley   +1 more source

Antisense Oligonucleotide-Based Therapy for Neuromuscular Disease

Molecules, 2017
Neuromuscular disorders such as Duchenne Muscular Dystrophy and Spinal Muscular Atrophy are neurodegenerative genetic diseases characterized primarily by muscle weakness and wasting.
V. Sardone, Haiyan Zhou, F. Muntoni, A. Ferlini, M. Falzarano   +4 more
semanticscholar   +1 more source

Antisense oligonucleotides and their applications in rare neurological diseases

Frontiers in Neuroscience
Rare diseases affect almost 500 million people globally, predominantly impacting children and often leading to significantly impaired quality of life and high treatment costs. While significant contributions have been made to develop effective treatments
Simon McDowall, Simon McDowall, May Aung-Htut, May Aung-Htut, Steve Wilton, Steve Wilton, Dunhui Li, Dunhui Li   +7 more
doaj   +1 more source