Results 121 to 130 of about 708,274 (274)

A Robust Strategy for Introducing Amino‐Modifiers in Nucleic Acids: Enabling Novel Amino Tandem Oligonucleotide Synthesis in DNA and RNA

Chemistry – A European Journal, EarlyView.
We report a simple, efficient, and cost‐effective methodology for introducing amino‐modifiers into DNA and RNA using a commercially available solid support. By incorporating a base‐labile sulfonyl linker within the strand, we developed an amino‐containing tandem oligonucleotide synthesis (aTOS) methodology, which enables the introduction of multiple ...
Jagandeep S. Saraya, Nicholas G. Horton, Scott R. Sammons, Derek K. O′Flaherty   +3 more
wiley   +1 more source

RNA Oligomerisation without Added Catalyst from 2′,3′‐Cyclic Nucleotides by Drying at Air‐Water Interfaces**

ChemSystemsChem, Volume 5, Issue 1, January 2023., 2023
Without catalyst! A non‐enzymatic, spontaneous route to the formation of short, mixed‐sequence RNA strands from 2′,3′‐cyclic ribonucleotides is shown. The reaction occurs by drying at the air–water interfaces. Abstract For the emergence of life, the abiotic synthesis of RNA from its monomers is a central step.
Avinash Vicholous Dass, Sreekar Wunnava, Juliette Langlais, Beatriz von der Esch, Maik Krusche, Lennard Ufer, Nico Chrisam, Romeo C. A. Dubini, Florian Gartner, Severin Angerpointner, Christina F. Dirscherl, Petra Rovó, Christof B. Mast, Judit E. Šponer, Christian Ochsenfeld, Erwin Frey, Dieter Braun   +16 more
wiley   +1 more source

Power-law Signatures and Patchiness in Genechip Oligonucleotide Microarrays [PDF]

arXiv, 2007
. Genechip oligonucleotide microarrays have been used widely for transcriptional profiling of a large number of genes in a given paradigm. Gene expression estimation precedes biological inference and is given as a complex combination of atomic entities on the array called probes.
arxiv  

In Vitro Psilocybin Synthesis by Co‐Immobilized Enzymes

Chemistry – A European Journal, EarlyView.
The drug candidate and psychedelic mushroom product psilocybin was produced by multienzyme‐charged beads in a biocatalytic cell‐free approach. Using immobilized fungal indolethylamine biosynthetic and additional bacterial enzymes, these beads turned over 4‐hydroxy‐l‐tryptophan to psilocybin.
Tim Schäfer, Alexander Sherwood, Thomas Kirkland, Thomas Krüger, Jakob Worbs, Olaf Kniemeyer, Markus Gressler, Dirk Hoffmeister   +7 more
wiley   +1 more source

Long-Tail Feature of DNA Words Over- and Under-Representation in Coding Sequences [PDF]

Computational Methods in Science and Technology 6, 65-71 (2000), 2001
We have analyzed DNA sequences of known genes from 16 yeast chromosomes (Saccharomyces cerevisiae) in terms of oligonucleotides. We have noticed that the relative abundances of oligonucleotide usage in the genome follow a long-tail Levy-like distribution.
arxiv  

Conserved Phosphorylation of the Myosin1e TH1 Domain Impacts Membrane Association and Function in Yeast and Worms

Cytoskeleton, EarlyView.
ABSTRACT Cells have an intrinsic ability to rapidly respond to environmental change to regulate cell cycle progression and membrane organisation, thereby affecting cell growth and division. The actin cytoskeleton is a highly dynamic complex of proteins that can rapidly reorganise to change the growth pattern of a cell.
Holly R. Brooker, Karen Baker, Marina Ezcurra, Philippe P. Laissue, Lin Wang, Michael A. Geeves, Jennifer M. Tullet, Daniel P. Mulvihill   +7 more
wiley   +1 more source

Inorganic Nanoparticles in Reproduction Biology: Opportunities and Challenges

ChemPlusChem, Accepted Article.
The development of inorganic metal and metal oxide nanoparticles (MNPs) has attracted significant attention in biomedical and biotechnological fields. An emerging field in this context is the use of MNPs in reproduction biology. Here, we review the development of MNPs in the field of reproduction by focusing on their interactions with highly delicate ...
Stephan Barcikowski, Sangita Kundu, Christoph Rehbock, Wilfried A. Kues   +3 more
wiley   +1 more source

Isolation and characterization of extracellular vesicles and future directions in diagnosis and therapy

WIREs Nanomedicine and Nanobiotechnology, Volume 15, Issue 1, January/February 2023., 2023
Fundamental research on EV isolation, standardization and characterisation will bring about translational medical diagnostics and therapy. Abstract Extracellular vesicles (EVs) are a unique and heterogeneous class of lipid bilayer nanoparticles secreted by most cells.
Karina P. De Sousa, Izadora Rossi, Mahamed Abdullahi, Marcel Ivan Ramirez, Dan Stratton, Jameel Malhador Inal   +5 more
wiley   +1 more source

Sustainable Synthesis, Characterization, Cellular Effects of Gold Nanoparticles and Their Applications as Therapeutics in Cancer Therapy

ChemPlusChem, Accepted Article.
In recent years, gold nanoparticles (AuNPs) have attracted much attention due to their extensive applications in fields such as biomedicine, electronics, catalysis, and environmental science. However, traditional chemical methods for AuNPs synthesis present certain challenges, such as the use of harsh chemicals and high energy consumption.
Youfeng Yue, Akihiro Moriyama, Marie Mita, Yue Yu   +3 more
wiley   +1 more source

Measuring the tail: Methods for poly(A) tail profiling

WIREs RNA, Volume 14, Issue 1, January/February 2023., 2023
A development of the methods used to study the length and composition of poly(A) tails, uncovering the 3′‐end tailing as a much more complex and impactful process than previously thought. Abstract The 3′‐end poly(A) tail is an important and potent feature of most mRNA molecules that affects mRNA fate and translation efficiency.
Aleksandra Brouze, Paweł Szczepan Krawczyk, Andrzej Dziembowski, Seweryn Mroczek   +3 more
wiley   +1 more source