Results 111 to 120 of about 80,761 (229)

Rapid identification of fungal pathogens in positive blood cultures using oligonucleotide array hybridization [PDF]

, 2010
Identification of fungal species in positive blood cultures using conventional methods can be time-consuming, particularly for non-albicans Candida species, non-Candida yeasts, and moulds. An oligonucleotide array system targeting the internal transcribe
Y-T. Huang, Y-L. Kuo, Liao, C-H., T-C. Chang, Kuo, Y-L., H-C. Hsiue, P-R. Hsueh, Hsiue, H-C., Hsueh, P-R., Huang, Y-T., Chang, T-C., C-H. Liao   +11 more
core   +1 more source

Dynamic Control of Nucleic Acids Self‐Assembly and Expression Using Photoswitches

Chemistry – A European Journal, EarlyView.
We review here the recent progress made in the design of molecular photoswitches, and highlight their implementation for the dynamic control over nucleic acids self‐assembly and expression. ABSTRACT Synthetic nucleic acids have become readily available and now constitute versatile building blocks in materials science—where they can be used to engineer ...
Noemí Nogal, Hugo Laigle, Maxime Mansy, Sébastien Ulrich, Mathieu Surin   +4 more
wiley   +1 more source

Robust detection and identification of multiple oomycetes and fungi in environmental samples by using a novel cleavable padlock probe-based ligation-detection assay [PDF]

, 2009
Simultaneous detection and identification of multiple pathogenic microorganisms in complex environmental samples are required in numerous diagnostic fields.
Dullemans, A.M., Slawiak, M., Dullemans, A., Van Doorn, R., Doorn, R., van, Kowalchuk, G.A., Doorn, R. van, Schoen, C.D., Szemes, M., Bonants, P.J.M., Bonants, P.   +10 more
core   +1 more source

Precision Chemistry for Protein Lysine Modification

Chemistry – A European Journal, EarlyView.
Selective modification of lysine residues is challenging due to their similar intrinsic reactivity. Inspired by enzymatic recognition, ligand‐guided electrophiles enable site‐selective labeling and functionalization, while ligand‐guided catalyses achieve regioselective installation of bio‐relevant post‐translational modifications.
Mayu Onoda, Motomu Kanai
wiley   +1 more source

Genetic epilepsies with myoclonic seizures: Mechanisms and syndromes

Epilepsia Open, EarlyView.
Abstract Genetic epilepsy with myoclonic seizures encompasses a heterogeneous spectrum of conditions, ranging from benign and self‐limiting forms to severe, progressive disorders. While their causes are diverse, a significant proportion stems from genetic abnormalities.
Antonietta Coppola, Marica Rubino, Antonella Riva, Pasquale Striano   +3 more
wiley   +1 more source

Systematic analysis of genomic alterations in prostate cancer [PDF]

, 2011
PhDProstate cancer is the most common male cancer in Western countries. The genetic mechanism underlying its initiation and progression is still unclear.
Mao, Xueying
core  

Genomic Diversity among Beijing and non-Beijing Mycobacterium tuberculosis Isolates from Myanmar [PDF]

, 2008
Background: The Beijing family of Mycobacterium tuberculosis is dominant in countries in East Asia. Genomic polymorphisms are a source of diversity within the M. tuberculosis genome and may account for the variation of virulence among M.
Hinds Jason, Grewal, HM, Butcher, PD, Stavrum Ruth, Stavrum, R, Bø, TH, Ruth Stavrum, Valvatne, H, Trond H Bø, Jonassen, I, Philip D Butcher, Valvatne Håvard, Bø Trond H., Hinds, J, Butcher Philip D., Jonassen Inge, Inge Jonassen, Jason Hinds, Håvard Valvatne, Harleen M S Grewal, Grewal Harleen M. S.   +20 more
core   +1 more source

Revolutionizing Healthcare With Paper‐Based Nucleic Acid Testing

Exploration, EarlyView.
This work summarizes strategies to enhance paper‐based devices for nucleic acid testing. Key approaches include optimizing paper platforms, improving nucleic acid amplification, and refining labeling/signaling methods. These advancements aim to boost sensitivity, speed, and usability, making paper‐based diagnostics more effective for point‐of‐care ...
Hong Zhang, Yi Yang, Heng Li, Xiaolin Hu, Hui Xiao, Dou Wang, Sergio Benardini, Wei Gu, Yang Luo   +8 more
wiley   +1 more source

Generation of Allogeneic CAR‐T Circumvents Functional Deficits in Patient‐Derived Autologous Product for Glioblastoma

International Journal of Cancer, EarlyView.
Clinical trials of chimeric antigen receptor T‐cell (CAR‐T) therapies in glioblastoma have shown limited clinical benefits. Whether this may be explained by the basal quality of CAR‐T products, which are currently generated using patient, autologous T‐cells, has been little explored.
Sabra K. Salim, Muhammad Vaseem Shaikh, Jeffrey Wei, William T. Maich, Alisha Anand, Oliver Y. Tang, Minomi K. Subapanditha, Zahra Alizada, Yujin Suk, Manoj Singh, Kui Zhai, Aapti Khanna, Benjamin Brakel, Vassil Dimitrov, Zoya Tabunshchyk, Katie Chan, Kevin R. Brown, Parvez Vora, Donald M. O'Rourke, Zev A. Binder, Chitra Venugopal, Jason Moffat, Sheila K. Singh   +22 more
wiley   +1 more source

Spatial omics in the AI era: Technologies, algorithmic ecosystems, biological applications, and large model perspectives

iMeta, EarlyView.
This review focuses on spatial omics, covering the introduction and comparison of technology platforms, explanation and recommendation of algorithm ecology, demonstration of biological applications, and prospect of large models. It aims to help researchers in the interdisciplinary field of spatial omics quickly understand the current situation and ...
Haoxiu Wang, Xinwang Yang, Siheng Wang, Zhe Yang, Xiuhui Yang, Yutong Yang, Zirong Li, Yuqi Ren, Qianqian Zhang, Bowen Zhao, Jingming Xiao, Yidong Wang, Junhao Dong, Zhenhao Kou, Jie Li, Liqun Yang, Erhu Zhao, Gregory Fonseca, Ruibang Luo, Mingyu Yang, Hongjuan Cui, Gengjie Jia, Dan Wang, Haoyang Li, Jun Ding, Zhiyuan Yuan, Haojing Shao   +26 more
wiley   +1 more source