Results 131 to 140 of about 130,578 (251)

The Incremental Yield of CMA Over Karyotype in Fetal Growth Restriction—A Systematic Review and Meta‐Analysis

Prenatal Diagnosis, EarlyView.
ABSTRACT The main objective of our study was to conduct a systematic literature review and a meta‐analysis to evaluate the incremental yield of chromosomal microarray analysis compared with karyotyping in cases of fetal growth restriction. Our review was designed according to the PRISMA guidelines.
Ioakeim Sapantzoglou, Evangelia Kontogeorgi, Vasilios Pergialiotis, Konstantinos Tasias, Angeliki Rouvali, Afroditi Pegkou, Marianna Theodora, Georgios Daskalakis, Panagiotis Antsaklis   +8 more
wiley   +1 more source

Advancing Extracellular Vesicle Research: A Review of Systems Biology and Multiomics Perspectives

PROTEOMICS, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐bound vesicles secreted by various cell types into the extracellular space and play a role in intercellular communication. Their molecular cargo varies depending on the cell of origin and its functional state.
Gloria Kemunto, Samaneh Ghadami, Kristen Dellinger   +2 more
wiley   +1 more source

Nature Inspired Delivery Vehicles for CRISPR‐Based Genome Editing

Small, EarlyView.
The review highlights nature‐inspired nanocarriers for CRISPR delivery, emphasizing viral vectors, extracellular vesicles, liposomes, and lipid nanoparticles. It discusses their roles in improving specificity, minimizing immunogenicity, and overcoming barriers in genome editing. Recent advancements, challenges, and therapeutic applications are explored,
Elizabeth Maria Clarissa, Mamata Karmacharya, Hyunmin Choi, Sumit Kumar, Yoon‐Kyoung Cho   +4 more
wiley   +1 more source

Orchestrating Self‐Replication in Artificial Cells with Digital Microfluidics

Small, EarlyView.
This work demonstrates controlled DNA replication and compartment division using digital microfluidics, enabling artificial cells to undergo repeated self‐replication cycles. The system couples physical manipulation with genetic continuity across generations, offering a simplified platform to explore the essential principles of self‐replicating living ...
Guanzhong Zhai, Pantelitsa Dimitriou, Jason Sengel, Mark Ian Wallace   +3 more
wiley   +1 more source

Enhancing the miRNA Detection Sensitivity of DNA Origami Book Biosensors Using Lock Modifications and a Polymer Additive

Small, EarlyView.
A dynamic DNA origami book biosensor enables simultaneous detection of microRNA‐21 (miR‐21) and microRNA‐7a (miR‐7a) in plasma from breast cancer patients. Using fluorescence resonance energy transfer (FRET) and quenching readouts, this programmable nanostructure achieves enzyme‐free detection within 10 minutes, highlighting its potential for sensitive,
Ivana Domljanovic, Samet Kocabey, Guillermo P. Acuna, Curzio Ruegg   +3 more
wiley   +1 more source

Regulatory T Cells and Nanomaterials: Dual Perspectives in Therapeutics and Immunomodulation

Small Science, EarlyView.
Tregs control immune tolerance but can also enable tumor escape. Nanomaterials can now expand or stabilize Tregs to treat autoimmunity and support transplantation or conversely disrupt tumor Tregs to boost antitumor immunity. We also discuss unintended Treg modulation by nanoparticles, safety and manufacturing challenges, and future translational ...
Yiyin Chen, Haibo Huang, Xiang Wang, Xinghao Yu, Ziyan Huang, Zhou Jin, Chen Chen, Yan Chen, Bruce R. Blazar, Yang Xu, Yunjie Lu   +10 more
wiley   +1 more source

Emerging Biomedical Engineering Therapies for Infected Diabetic Foot Ulcers: Toward Antibacterial Functionalization and Pathology‐Responsive Regulation

Small Science, EarlyView.
Infected diabetic foot ulcer endangers patients with high amputation, disability, mortality risks, and heavy medical burdens. This review analyzes its pathogenic factors, the limitations of current treatments, the breakthroughs of responsive antimicrobial biomaterials, and the challenge of multifunctional biomaterial innovations for further developing ...
Yaqi Yao, Mengyi Huang, Yuetong Li, Yiqi Lin, Junjie Dong, Jianhang Du, Aixia Zhai, Changlong Bi, Luoyuan Li   +8 more
wiley   +1 more source

Design, Mechanisms, and Applications of DNA‐Mediated Dynamically Reconfigurable Plasmonic Gold Nanostructures

Small Methods, EarlyView.
This review provides key principles of designing and synthesizing reconfigurable plasmonic gold nanostructures for generating and controlling physical, chemical, and biological properties and functions. The recent advances in the biological and materials applications of dynamically reconfigurable plasmonic gold nanostructures are also summarized ...
So Young Choi, Jieun Kim, Eun Ho Song, Eunhye Park, Jingrui Wu, Juyeon Yoo, Jwa‐Min Nam   +6 more
wiley   +1 more source

Efficiency of Digital Photolithographic Synthesis of Large, High-Quality DNA Libraries and Microarrays using a Guanine O⁶ Dephosphitylation Strategy. [PDF]

Commun Chem
Santhosh S, Istvánffy S, Sabary O, Yaakobi E, Giridhar M, Behr J, Somoza MM.   +6 more
europepmc   +1 more source

High‐Yield Assembly of Plasmon‐Coupled Nanodiamonds Using DNA Origami for Tuned Emission

Small Structures, EarlyView.
Engineering assemblies of single‐photon emitters and plasmonic elements with nanometer precision opens pathways for quantum sensing and photonics applications. A surface functionalization strategy is established for grafting DNA onto nanodiamonds, and their placement on DNA origami is optimized to achieve yields above 50%.
Niklas Hansen, Jakub Čopák, Marek Kindermann, David Roesel, Federica Scollo, Ilko Bald, Petr Cigler, Vladimíra Petráková   +7 more
wiley   +1 more source