Results 151 to 160 of about 80,761 (229)

Synthesis of highly complex phosphorothioate-modified oligonucleotides on microarrays. [PDF]

Sci Rep
Ilić I, Schaudy E, Lietard J.
europepmc   +1 more source

Patient‐derived forebrain cortical organoids reveal biphasic tau–MAP6–microtubule axis dysfunction in tauopathy

Alzheimer's &Dementia, Volume 22, Issue 7, July 2026.
Abstract INTRODUCTION In frontotemporal dementia (FTD), tau detaches from axonal microtubules and forms pathological aggregates. Rather than stabilizing microtubules, tau promotes labile microtubule domains, redefining its role in neurodegeneration and underscoring the need for human models that capture temporal disease progression.
Xiaohuan Sun, Skandha Ramakrishnan, Victor C. Ogbolu, Nicholas M. Kanaan, Celeste M. Karch, Peter W. Baas, Liang Qiang   +6 more
wiley   +1 more source

Combinatorial and rational synthesis of complex, base-modified aptamer libraries on microarrays. [PDF]

RSC Adv
Schaudy E, Lietard J.
europepmc   +1 more source

Toward Comprehensive Clinical Genomics: Integrating Exon-Level Analysis for Detecting Monogenic Copy Number Variations. [PDF]

Ann Lab Med
Seo EJ.
europepmc   +1 more source

Fabrication of microcolumn arrays for high-throughput oligonucleotide synthesis using 3D printing. [PDF]

Sci Rep
Kim H, Kim J, Bang D.
europepmc   +1 more source

A Modular Mechanistic In Silico Model for In Vitro Transcription Process Yield and Product Quality Prediction

Biotechnology and Bioengineering, Volume 123, Issue 7, Page 1836-1870, July 2026.
ABSTRACT In vitro transcription (IVT) plays a critical role in the manufacture of mRNA vaccines and therapeutics. Optimizing mRNA yield and ensuring product quality, such as capping efficiency and integrity, are essential but mechanistically complex. This study presents a modular mechanistic model of the IVT process to advance scientific understanding ...
Keqi Wang, Keilung Choy, Eli Reiser, Jinxiang Pei, Hua Zheng, Aparajita Dasgupta, Fuqiang Cheng, Guogang Dong, Bhanu Chandra Mulukutla, Joshua Mannheimer, Carolyn Huang, Hooman Farsani, Wei Xie   +12 more
wiley   +1 more source

Efficiency of Digital Photolithographic Synthesis of Large, High-Quality DNA Libraries and Microarrays using a Guanine O⁶ Dephosphitylation Strategy. [PDF]

Commun Chem
Santhosh S, Istvánffy S, Sabary O, Yaakobi E, Giridhar M, Behr J, Somoza MM.   +6 more
europepmc   +1 more source

Tumour‐macrophage crosstalk initiated by NFIC/METTL3 negative feedback loop via exosomal miR‐194‐5p promotes NSCLC progression

Clinical and Translational Medicine, Volume 16, Issue 7, July 2026.
NFIC/METTL3 negative feedback loop in NSCLC cells suppresses exosomal miR‐194‐5p via m6A methylation; reduced miR‐194‐5p deepresses ZNF106 in macrophages, promoting M2 polarization and IL‐6 secretion; Macrophage‐derived IL‐6 activates JAK2/STAT3 in NSCLC cells to upregulate METTL3, forming a positive feedback loop.
Shu Fang, Mingyue Hao, Han Meng, Yuhang Jiang, Qiwen Li, Jiao Liang, Xiaolu He, Yi Hu, Linling Zhou, Qianrun Wang, Qiyuan Zhuo, Ji Wu, Kesong Shi   +12 more
wiley   +1 more source

CTLA-4 Antisense Oligonucleotide Contributes to Enhanced Immunogenicity of an Adjuvanted Recombinant <i>Sporothrix</i> spp. Enolase Antigen. [PDF]

Vaccines (Basel)
Momente GJ, Portuondo DL, Deus AF, Curti Gonçalves MR, Piccineli FL, de Oliveira Campos TPC, Téllez-Martínez D, Carlos IZ, Batista-Duharte A.   +8 more
europepmc   +1 more source

Cytogenetic Analysis of Altitude‐Associated Chromosome Variations in Campeiostachys nutans From Western Sichuan Plateau Using Multicolor GISH and ND‐FISH Approaches

Ecology and Evolution, Volume 16, Issue 7, July 2026.
The genomic and chromosomal organization of C. nutans was investigated using GISH and ND‐FISH with four oligonucleotide probes. The results showed that repetitive sequence distribution exhibited genome‐specific patterns: the H genome demonstrated high structural stability with low polymorphism, while the St genome showed moderate variation, and the Y ...
Cairong Yang, Jiezhi Yang, Yi Ou, Yueju Zhou, Zhimeng Wang, Weiliang Qi, Dingfang Luo, Yutong Qiao   +7 more
wiley   +1 more source