Results 171 to 180 of about 23,719,178 (251)

FLInt 2.0: robust and customizable single-shot integration in C. elegans. [PDF]

G3 (Bethesda)
Malaiwong N, Malaiwong P, Kim C, O'Donnell M.   +3 more
europepmc   +1 more source

Myelin Impairment and Regeneration in the Central Nervous System: Molecular Mechanisms, Diseases, and Prospective Therapeutic Targets

MedComm, Volume 7, Issue 10, October 2026.
Proper myelin formation is crucial for normal neural circuit function, while myelin deficiency can lead to neural circuit dysfunction and cognitive decline, notably in Alzheimer's disease and other central nervous system demyelinating disorders. This review summarizes central myelin's structure and function, demyelination biomarkers and pathological ...
Lihong Huang, Peng Cheng, Guangdong Liu, Yang Xiang, Zhen Hong, Weidong Le   +5 more
wiley   +1 more source

CTLA-4 Antisense Oligonucleotide Contributes to Enhanced Immunogenicity of an Adjuvanted Recombinant <i>Sporothrix</i> spp. Enolase Antigen. [PDF]

Vaccines (Basel)
Momente GJ, Portuondo DL, Deus AF, Curti Gonçalves MR, Piccineli FL, de Oliveira Campos TPC, Téllez-Martínez D, Carlos IZ, Batista-Duharte A.   +8 more
europepmc   +1 more source

Hippo Pathway–YAP/TAZ Signaling: Molecular Mechanisms, Biological Function, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 10, October 2026.
The Hippo–YAP/TAZ–TEAD pathway integrates mechanical and biochemical cues to govern organ growth, regeneration, cancer, and fibrosis. This review dissects pathway physiology, TEAD structural pharmacology and ligandable pockets, and therapeutic strategies spanning palmitoylation‐pocket inhibitors, PROTAC degraders, and gene/RNA therapies, highlighting ...
Xiaodan Qu, Zhan‐you Wang
wiley   +1 more source

Insights Into Spatial Transcriptomics: Exploring Recent Technical Developments and Their Diverse Applications. [PDF]

FASEB J
Li X, Yang Z, Li J, Cao H, Xu K, Shen J, Wang Y, Gomaa SE, Cheng G, Teng T, Li J, Wang X, Dong X.   +12 more
europepmc   +1 more source

Building coiled coils with polar cores

Protein Science, Volume 35, Issue 10, October 2026.
Abstract Coiled coils are formed by α‐helices winding around each other into superhelical bundles. They are characterized by a specific geometry of interaction, called knobs‐into‐holes, in which residues in the core of the structure mesh regularly along a seam that runs the length of the helices.
Marcus D. Hartmann, Birte Hernandez Alvarez, Mikel Martinez‐Goikoetxea, Andrei N. Lupas   +3 more
wiley   +1 more source

Mapping subcellular microenvironments using oligonucleotide-directed proximity labeling. [PDF]

Curr Opin Chem Biol
Schactler SA, Skiados NG, Gajendragadkar AA, DeLeon LE, Shechner DM.   +4 more
europepmc   +1 more source

Engineering Photothermal Nanoplatforms for Multimodal Theranostics and Biosensing

Rare Metals, Volume 45, Issue 10, October 2026.
ABSTRACT Photothermal platforms bridge materials science and biomedicine, emerging as a transformative frontier in biomedical applications. They offer spatiotemporally precise, noninvasive modalities with cell‐type‐independent efficacy for treating a range of diseases.
Xiao Han, Peng Jin, Haiqing Wang, Hao Xue   +3 more
wiley   +1 more source

Fluorous-Directed Clamping Stabilizes Triple-Helical DNA. [PDF]

ACS Omega
Taladriz-Sender A, Brazzill M, Withers JM, Clark AW, Burley GA, Rusling DA.   +5 more
europepmc   +1 more source

Extracellular Vesicles From Senescent Cancer Cells Are Necessary and Sufficient to Drive Paracrine Senescence

Aging Cell, Volume 25, Issue 10, October 2026.
Senescent cancer cells exhibit a secretory phenotype, known as SASP, capable of inducing paracrine senescence. However, the main factors within the SASP triggering this process are unknown. Here, we demonstrate that EVs within the SASP are necessary and sufficient to induce paracrine senescence.
Valentin Estevez‐Souto, Alex Miralles‐Dominguez, Pablo Pedrosa, Patricia Lado‐Fernandez, Miguel A. Prados, Alejandro Failde‐Fiestras, Raquel Paredes‐Paredes, Jorge Ruz‐Ortega, Maria J. Alonso, Martina Migliavacca, Ester Polo, Rebeca Alvarez‐Velez, Enrique Vazquez de Luis, Ana Dopazo, Gabriela N. Condezo, Carmen San Martin, Miguel Gonzalez‐Barcia, Ramón Lobato‐Busto, Pilar Ximénez‐Embún, Javier Muñoz, Manuel Collado, Sabela Da Silva‐Alvarez   +21 more
wiley   +1 more source