Results 151 to 160 of about 708,274 (274)

Haplotype mining panel for genetic dissection and breeding in Eucalyptus

The Plant Journal, Volume 113, Issue 1, Page 174-185, January 2023., 2023
SUMMARY To improve our understanding of genetic mechanisms underlying complex traits in plants, a comprehensive analysis of gene variants is required. Eucalyptus is an important forest plantation genus that is highly outbred. Trait dissection and molecular breeding in eucalypts currently relies on biallelic single‐nucleotide polymorphism (SNP) markers.
Julia Candotti, Nanette Christie, Raphael Ployet, Marja M. Mostert‐O'Neill, S. Melissa Reynolds, Leandro Gomide Neves, Sanushka Naidoo, Eshchar Mizrachi, Tuan A. Duong, Alexander A. Myburg   +9 more
wiley   +1 more source

Repurposing large-format microarrays for scalable spatial transcriptomics. [PDF]

Nat Methods
Cipurko D, Ueda T, Mei L, Chevrier N.
europepmc   +1 more source

Key Considerations on CITE‐Seq for Single‐Cell Multiomics

PROTEOMICS, EarlyView.
ABSTRACT CITE‐Seq (Cellular Indexing of Transcriptomes and Epitopes by Sequencing) is an advanced single‐cell sequencing method to profile both gene expression and protein abundance simultaneously in individual cells using single‐cell mRNA sequencing techniques alongside antibody‐derived tags (ADTs), for protein detection.
Hye‐Wong Song, Jody Martin, Xiaoshan Shi, Aaron J. Tyznik   +3 more
wiley   +1 more source

Sensor Arrays for Electrochemical Detection of PCR-Amplified Genes Extracted from Cells Suspended in Environmental Waters. [PDF]

Sensors (Basel)
Aoki H, Kawaguchi M, Kumakura Y, Kamo H, Miura K, Hiruta Y, Simizu S, Citterio D.   +7 more
europepmc   +1 more source

A Population Pharmacokinetic Model to Inform Extension of the Eteplirsen Dosing Regimen Across the Broad DMD Population

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Duchenne muscular dystrophy (DMD) is characterized by progressive, irreversible muscle damage that usually leads to premature death from cardiac or respiratory failure. Eteplirsen is a phosphorodiamidate morpholino oligomer and the first antisense oligonucleotide (ASO) approved for the treatment of patients with exon 51 skip‐amenable DMD. This
Yogesh Patel, Larry Orogun, Nicole Yocum, Louise R. Rodino‐Klapac, Lilly East   +4 more
wiley   +1 more source

Nature Inspired Delivery Vehicles for CRISPR‐Based Genome Editing

Small, EarlyView.
The review highlights nature‐inspired nanocarriers for CRISPR delivery, emphasizing viral vectors, extracellular vesicles, liposomes, and lipid nanoparticles. It discusses their roles in improving specificity, minimizing immunogenicity, and overcoming barriers in genome editing. Recent advancements, challenges, and therapeutic applications are explored,
Elizabeth Maria Clarissa, Mamata Karmacharya, Hyunmin Choi, Sumit Kumar, Yoon‐Kyoung Cho   +4 more
wiley   +1 more source

Comparison of the BluePoint MoldID oligonucleotide array and Bruker Biotyper MALDI-TOF MS for the identification of filamentous fungi. [PDF]

J Clin Microbiol
Chou C-H, Chao Q-T, Lu Y-S, Lee T-F, Hsueh P-R, Huang Y-T, Liao C-H.   +6 more
europepmc   +1 more source

NIR‐Induced Photoswitching Hybrid DNA Nanoconstruct‐Based Drug Delivery System for Spatiotemporal Control of Stem Cell Fate

Small, EarlyView.
NIR‐mediated photo‐switching drug delivery system for the remote‐control differentiation of NSCs. Left: NIR‐mediated curcumin release is induced by NIR‐to‐UV photon upconversion in a photo‐controllable manner. Curcumin is bound in the minor groove of the synthesized DNA construct containing AAP photo‐switchers. Right: The rational design of several AAP
Thanapat Pongkulapa, Ji Hye Yum, Callan D. McLoughlin, Brandon Conklin, Tomotaka Kumagai, Li Ling Goldston, Hiroshi Sugiyama, Soyoung Park, Ki‐Bum Lee   +8 more
wiley   +1 more source

Structural basis for control of integrative and conjugative element excision and transfer by the oligomeric winged helix-turn-helix protein RdfS. [PDF]

Nucleic Acids Res
Verdonk CJ, Agostino M, Eto KY, Hall DA, Bond CS, Ramsay JP.   +5 more
europepmc   +1 more source

Controlled Nanoconfinement in a Microfluidic Modular Bead Array Device via Elastomeric Diaphragm Collapse for Enhancing Biomolecular Binding Kinetics

Small, EarlyView.
A modular platform for controlled nanoconfinement over a large area is presented using an elastomeric diaphragm integrated with strain sensors and microfabricated posts (≈500 nm) to enhance biomolecular binding by alternating between confinement and bulk transport for rapid DNA immobilization and screening aptamers on their binding affinities to target
Abdullah‐Bin Siddique, Jui‐Hong Weng, Deng‐Kai Yang, Chia‐Fu Chou, Nathan S. Swami   +4 more
wiley   +1 more source