Results 151 to 160 of about 79,402 (200)

Development and Characterization of Wheat-<i>Thinopyrum elongatum</i> 1B-1E Translocation Lines with Fusarium Head Blight Resistance. [PDF]

Plants (Basel)
Wang C, Liu Z, Wang X, Wang X, Guo X, He H, Wang A, Cao Y, Zhang W.   +8 more
europepmc   +1 more source

Gene therapy for epilepsy: An emerging, promising approach for a serious neurological disorder

Journal of Internal Medicine, Volume 299, Issue 3, Page 302-327, March 2026.
Abstract Gene therapy is emerging as a groundbreaking strategy for treating epilepsy, offering new hope to patients who do not respond to conventional medications. Despite advancements in anti‐seizure treatments, nearly 30%–40% of individuals with epilepsy continue to experience uncontrolled seizures, highlighting the urgent need for more effective and
Marco Ledri, Merab Kokaia
wiley   +1 more source

Long-read genome sequencing resolves the breakpoints of a chromosome 8;22 balanced translocation in NF2-related schwannomatosis. [PDF]

Sci Rep
Montini M, Bonacchi L, Sidoti D, Cuccoli S, Pantaleo M, Peron A, Scuffi I, DosSantos MF, Nassini R, De Logu F, Papi L.   +10 more
europepmc   +1 more source

Frizzled‐9 Expression Is Associated With Aggressive Clinicopathological Features and Reduced Overall Survival in Invasive Breast Carcinoma

Pathology International, Volume 76, Issue 3, March 2026.
Graphical summary illustrating the evaluation of FZD9 in breast cancer. FZD9 protein expression was assessed by immunohistochemistry in 81 breast tumor samples and further investigated in breast cancer cell lines exposed to cytotoxic and epigenetic treatments. Higher FZD9 expression was associated with aggressive clinicopathological features and poorer
Daniel Rodrigues de Bastos, Ricardo Cesar Cintra, Adhemar Longatto‐Filho, Lara Termini   +3 more
wiley   +1 more source

A rare 5'UTR variant in SEC24D reveals translational dysfunction in osteogenesis imperfecta: a roadmap for RNA therapeutic rescue. [PDF]

Sci Rep
Essawi O, Jarayseh T, Tapaneeyaphan P, Bouckaert M, Naessens S, Malfait F, Coppieters F, Coucke PJ.   +7 more
europepmc   +1 more source

Characterization of Phytoene Desaturase Knockout Carotenoid‐Deficient Microalgal Mutants Generated by Cas9‐Ribonucleoprotein Complexes

Physiologia Plantarum, Volume 178, Issue 2, March/April 2026.
ABSTRACT Phytoene desaturase (PDS; EC 1.3.5.5) is a key enzyme of the carotenoid biosynthetic pathway, catalyzing the desaturation of phytoene, precursor of all carotenoids. In this study, several PDS‐knockout (PDS‐KO) transformants of the chlorophyte microalga Chlamydomonas reinhardtii were generated using a reverse genetics strategy. Two single guide
Ana Molina‐Márquez, Simon Kelterborn, Peter Hegemann, Miguel Pérez‐Rodríguez, Javier Vigara, Rosa León   +5 more
wiley   +1 more source

Divergent viral phosphodiesterases for immune signaling evasion. [PDF]

Cell Host Microbe
Doherty EE, Nomburg J, Adler BA, Lopez S, Hsieh K, Price N, Blount N, Doudna JA.   +7 more
europepmc   +1 more source

Human Dorsal Root Ganglia Neuronal Cell Line to Study Nociceptive Signaling: A New Pipeline for Pain Therapy

The FASEB Journal, Volume 40, Issue 3, 15 February 2026.
The nociceptive properties of differentiated human HD10.6 cells were characterized by multiple approaches (A). Peripheral sensitization was induced within HD10.6 cells in response to an inflammatory cocktail (B), modeling nociceptors in a chronic pain state.
Sara A. Dochnal, Yixing Du, Daniella Bandari, Kaue Franco Malange, Jack Bryant, Julia Borges Paes Lemes, Abby Whitford, Anna R. Cliffe, Prashant Mali, Kim Dore, Yury I. Miller, Tony L. Yaksh   +11 more
wiley   +1 more source

Rethinking genomics of facioscapulohumeral muscular dystrophy in the telomere-to-telomere era: pitfalls in the hidden landscape of D4Z4 repeats. [PDF]

Eur J Hum Genet
Salsi V, Losi F, Pini S, Chiara M, Tupler R.   +4 more
europepmc   +1 more source

Subtelomeric elements provide stability to short telomeres in telomerase-negative cells of the budding yeast Naumovozyma castellii. [PDF]

Curr Genet
Jaiswal RK, Garibo Domingo T, Grunchec H, Singh K, Pirooznia M, Elhaik E, Cohn M.   +6 more
europepmc   +1 more source