Results 171 to 180 of about 131,505 (250)

Development and Characterization of Wheat-<i>Thinopyrum elongatum</i> 1B-1E Translocation Lines with Fusarium Head Blight Resistance. [PDF]

Plants (Basel)
Wang C, Liu Z, Wang X, Wang X, Guo X, He H, Wang A, Cao Y, Zhang W.   +8 more
europepmc   +1 more source

Ion Mobility Gas-Phase Separation Enhances Top-Down Mass Spectrometry of Heavily Modified Guide RNA. [PDF]

Anal Chem
Macias LA, Lowther J, Tillotson EL, Rohde E, Madsen JA.   +4 more
europepmc   +1 more source

Multi‐Omic Profiling of T Cell‐Mediated Rejection After Kidney Transplantation Reveals B Cell Receptor Repertoire Expansion and Its Prognostic Relevance

The FASEB Journal, Volume 40, Issue 1, 15 January 2026.
This study integrates bulk and single‐cell RNA‐seq data to reveal significant B cell receptor (BCR) repertoire expansion, especially IgG isotype amplification, in T cell‐mediated rejection (TCMR) after kidney transplantation. Multi‐omic integration identifies plasma cells as the main BCR carriers in graft tissue and MEI1 as a key regulator promoting ...
He Zhang, Di Zhang, Yuhong Hu, Hao Zhang, Zijian Zhang, Xiaopeng Hu   +5 more
wiley   +1 more source

A rare 5'UTR variant in SEC24D reveals translational dysfunction in osteogenesis imperfecta: a roadmap for RNA therapeutic rescue. [PDF]

Sci Rep
Essawi O, Jarayseh T, Tapaneeyaphan P, Bouckaert M, Naessens S, Malfait F, Coppieters F, Coucke PJ.   +7 more
europepmc   +1 more source

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, Volume 600, Issue 2, Page 239-250, January 2026.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source

Divergent viral phosphodiesterases for immune signaling evasion. [PDF]

Cell Host Microbe
Doherty EE, Nomburg J, Adler BA, Lopez S, Hsieh K, Price N, Blount N, Doudna JA.   +7 more
europepmc   +1 more source

Growth Differentiation Factor 15 Elevation in the Central Nervous System Is Associated With Failure to Thrive in Alexander Disease

Annals of Clinical and Translational Neurology, Volume 13, Issue 1, Page 144-156, January 2026.
ABSTRACT Objective Alexander disease (AxD) is a severe neurodegenerative disorder caused by gain‐of‐function mutations in the gene for GFAP, which lead to protein aggregation and a primary astrocytopathy. Symptoms vary, but failure to thrive (FTT) and frequent emesis are common and cause significant morbidity. Here we investigate GDF15, a member of the
Tracy L. Hagemann, Michelle M. Sonsalla, Cora Luzinski, Fernando Zacahua, David A. Harris, Dudley W. Lamming, Albee Messing   +6 more
wiley   +1 more source

Subtelomeric elements provide stability to short telomeres in telomerase-negative cells of the budding yeast Naumovozyma castellii. [PDF]

Curr Genet
Jaiswal RK, Garibo Domingo T, Grunchec H, Singh K, Pirooznia M, Elhaik E, Cohn M.   +6 more
europepmc   +1 more source

Reconfigurable Nucleic Acid Nanoparticles with Therapeutic RNAi Responses to Intracellular Disease Markers

Advanced Functional Materials, Volume 36, Issue 5, 15 January 2026.
Many known diseases arise from dysregulated gene expression, and differentially expressed genes can serve as biomarkers to distinguish diseased cells from healthy tissues. In this study, reconfigurable nucleic acid nanoparticles (recNANPs) are introduced that can detect overexpressed cancer biomarkers and subsequently release RNAi inducers to silence ...
Yelixza I. Avila, Anh Ha, Morgan R. Chandler, Nathalia Leal Santos, Taejin Kim, Hannah S. Newton, Marina A. Dobrovolskaia, Kirill A. Afonin   +7 more
wiley   +1 more source

A Rapid, High-Throughput Method for the Construction of Mutagenesis Libraries. [PDF]

Biomolecules
Lu Y, Meng S, Guan X, He P, Zhao D.
europepmc   +1 more source