Results 191 to 200 of about 131,505 (250)

DNA methylation shapes transcription factor binding beyond canonical CpG contexts. [PDF]

Proc Natl Acad Sci U S A
Miodownik I, Solozabal R, O'Hagan MP, Albeck S, Peleg Y, Takac M, Afek A.   +6 more
europepmc   +1 more source

A Pan‐TE Map Reveals the Important Role of Transposable Elements in Gene Expression and Phenotypic Diversity in 2,311 Rapeseed Accessions

Advanced Science, Volume 13, Issue 4, 19 January 2026.
This study presents the first pan‐transposable element (TE) atlas in rapeseed, profiling over 8 million TEs across 2311 accessions. Integrative analyses reveal that TEs broadly shape gene expression through diverse regulatory mechanisms, with key insertions in BnaA03.FLC and BnaA09.CYP78A9 linked to flowering time and silique development.
Zhiquan Yang, Haiyan Fan, Yifan Chen, Jiawei Li, Minjian Chen, Yingying Tan, Liang Guo, Jintao Li, Kede Liu, Qing‐Yong Yang   +9 more
wiley   +1 more source

Genome-Wide, High-Density Genotyping Approaches for Plant Germplasm Characterisation (Methods and Applications). [PDF]

Int J Mol Sci
Werghi S, Koboyi BW, Chan-Rodriguez D, Bolibok-Brągoszewska H.   +3 more
europepmc   +1 more source

Aptamer‐Engineered Ellipsometry for Clinical Detection of BALF‐Derived Exosomes: Multi‐Level Engineering for Prognostic Evaluation of Immunotherapy Responses

Advanced Science, Volume 13, Issue 3, 14 January 2026.
A novel ellipsometry platform functionalized with truncated PD‐L1 aptamers are developed to enable ultrasensitive detection of BALF‐derived exosomes. Through chemical ligand tailoring, mechanical sensing optimization, and tumor‐proximal fluid sampling, the system precisely stratifies ICI responders and non‐responders, offering superior sensitivity and ...
Euna Jeong, Jung Hyun Choi, Minyoung Lee, Jun Hyeok Lim, Seokho Jung, Yeeun Woo, Joo‐young Kim, Jaehyeon Ok, Lucia Kim, Woo‐jin Jeong, Won Chegal, Hyun Mo Cho, Chulhwan Park, Jiyoon Bu, Dong Hyung Kim, Taek Lee   +15 more
wiley   +1 more source

Mitochondrial mRNA oligocitydylation occurs in Chlorophyceae and Ulvales but not Bryopsidales or Trebouxiophyceae. [PDF]

J Phycol
Cahoon AB, Maggard IJ, Pathan WN.
europepmc   +1 more source

Aptamer Engineering: Strategies for Discovering Functional Nucleic Acids for Next‐Generation Diagnostics and Biosensing

Advanced Science, Volume 13, Issue 2, 9 January 2026.
The advent of aptamers has highlighted their potential as alternatives to antibodies, overcoming limitations of structural instability and production cost. However, conventional approaches such as SELEX remain slow and labor‐intensive. This review examines recent advances in aptamer engineering, emphasizing in vitro and AI‐driven in silico strategies ...
John V. L. Nguyen, Ahlem Meziadi, Cyrill Brunner, Maureen McKeague, Lidija Malic, Maryam Tabrizian   +5 more
wiley   +1 more source

Tissular chromatin-state cartography based on double-barcoded DNA arrays that capture unloaded PA-Tn5 transposase. [PDF]

Genome Res
Mendoza-Ferri MG, Lozachmeur G, Duvina M, Perret L, Merciris D, Gigout A, Mendoza-Parra MA.   +6 more
europepmc   +1 more source

Exploring the Role of Long Noncoding RNAs in Breast Cancer Progression: A Comprehensive Study on Biomarkers and Therapeutic Approaches

Cancer Medicine, Volume 15, Issue 1, January 2026.
ABSTRACT Background Among the many forms of cancer that plague women all over the globe, breast cancer (BC) is one of the most prevalent kinds. BC is a multifaceted disease that can manifest in many ways depending on the individual. Aims The identification of new biomarkers that may be used to diagnose and prognosis of the BC, as well as those that can
Ramin Moeini, Amin AhsanAlkhat, Saeid Ghorbian   +2 more
wiley   +1 more source

High-throughput DNA melt measurements enable improved models of DNA folding thermodynamics. [PDF]

Nat Commun
Ke Y, Sharma E, Wayment-Steele HK, Becker WR, Ho A, Marklund E, Greenleaf WJ.   +6 more
europepmc   +1 more source

Unlocking Biomolecule Modification with Light‐Promoted Photocatalyst‐Free Approaches: Current Tools, Challenges, and Perspectives

ChemistryEurope, Volume 4, Issue 1, January 2026.
This Perspective focuses on photocatalyst‐free, photoinduced modifications of biomolecules, emphasizing transformations mediated by electron donor–acceptor complexes. Mechanistic aspects, current limitations, and future opportunities are discussed, providing insight into the field of bioconjugation.
Milene Hornink, Maria Eduarda C. Thedy, Eugénie Romero, Gary A. Molander   +3 more
wiley   +1 more source