Results 191 to 200 of about 130,578 (251)

Self‐Propelled Magnetic Micromotor‐Functionalized DNA Tile System for Autonomous Capture of Circulating Tumor Cells in Clinical Diagnostics

Advanced Science, Volume 12, Issue 45, December 4, 2025.
The magnetic micromotor‐functionalized DNA‐array hunter (MMDA hunter), integrating autonomous propulsion and precision‐partitioned functionalities, utilizes DNA array programmability and 5'‐3' directional control to achieve spatially partitioned module arrangement.
Qiumei Pu, Liangqing Lu, Yanghong Zhao, Dongxia Li, Mengli Yao, Qionglin Zhou, Xinxin Xiao, Yuzhong Jia, Xuan Zhao, Xiangde Lai, Qian Chen, Yuxiang Ji, Bin Qiao, Hua Pei, Yanan Peng, Qiang Wu   +15 more
wiley   +1 more source

Rapid screening of mutations for second-line-drug-resistant genes in Mycobacterium tuberculosis culture isolates by in-house developed DNA bio-chip. [PDF]

Eur J Clin Microbiol Infect Dis
Jain B, Kulkarni S, Baghel NS.
europepmc   +1 more source

Enhanced One‐Pot Dual‐CRISPR‐Based Assay Lyophilized on a 3D‐Printed Disc for Field‐Deployable Multiplex Bacteria Detection

Advanced Science, Volume 12, Issue 45, December 4, 2025.
An enhanced one‐pot, helicase‐assisted recombinase polymerase amplification (hRPA)‐combined, dual‐CRISPR/uAsCas12a assay is developed and lyophilized on a 3D‐printed microfluidic disc to achieve field‐deployable multiplex bacteria detection. Abstract One‐pot CRISPR‐based detection combining recombinase polymerase amplification (RPA) enables rapid and ...
Yuqing Shen, Bo Lu, Biao Ma, Xiong Ding
wiley   +1 more source

The arms race in bacteria-phage interaction: deciphering bacteria defense and phage anti-defense mechanisms through metagenomics. [PDF]

Front Microbiol
Zhang S, Chu M, Sun X.
europepmc   +1 more source

Targeted Proteomics upon Treatment with Tofersen Identifies Novel Response Markers for Superoxide Dismutase 1‐Linked Amyotrophic Lateral Sclerosis

Annals of Neurology, Volume 98, Issue 6, Page 1318-1334, December 2025.
Objective Tofersen is the first effective and approved therapy for superoxide dismutase 1 (SOD1)‐associated amyotrophic lateral sclerosis (ALS [SOD1‐ALS]). Following treatment with tofersen, neurofilament levels in patients' cerebrospinal fluid (CSF) and serum seem to respond earlier than clinical parameters.
Christina Steffke, Karthik Baskar, Franziska Bachhuber, Maximilian Wiesenfarth, Johannes Dorst, Joachim Schuster, Florian Schöberl, Peter Reilich, Martin Regensburger, Alexander German, René Günther, Maximilian Vidovic, Susanne Petri, Thomas Meyer, Tim Hagenacker, Julian Grosskreutz, Ute Weyen, Patrick Weydt, Thomas Haarmeier, Paul Lingor, Joachim Wolf, Andreas Hermann, Johannes Prudlo, Kornelia Günther, Antje Knehr, Zeynep Elmas, Zeljko Uzelac, Simon Witzel, Wolfgang Philipp Ruf, Axel Freischmidt, Ritchie Ho, Albert C. Ludolph, Jochen H. Weishaupt, Hayrettin Tumani, Patrick Oeckl, David Brenner, Alberto Catanese   +36 more
wiley   +1 more source

Na⁺ selective structural switch from an intramolecular triplex to tetrad stabilised by non-canonical mispairs in double repeat of <i>Arabidopsis thaliana</i> telomere (T₃AG₃)₂. [PDF]

Biochem Biophys Rep
Bansal A, Phogat P, Kukreti S.
europepmc   +1 more source

Spectrometry and Its Application for the Detection of RNA‐Binding Proteins: Advancements, Techniques and Challenges

Analytical Science Advances, Volume 6, Issue 2, December 2025.
ABSTRACT Spectrometry is a fascinating field of analytical science that encompasses a range of techniques used to study the interaction between electromagnetic radiation and matter. Through the measurement and analysis of various radiations, spectrometry provides valuable insights into the composition, structure and properties of different substances ...
Mina Moradi, Zahra Farjami, Mohammad Mehdi Akbarin   +2 more
wiley   +1 more source

One-carbon metabolism modulates miR-29a-DNA methylation crosstalk in Alzheimer's disease. [PDF]

Alzheimers Dement
Raia T, Cavallaro RA, Borges LDF, Cinti S, Bizzarri M, Ferrer I, Lucarelli M, Fuso A.   +7 more
europepmc   +1 more source

Computational Framework for High Copy‐Number Probe Selection and Cross‐Binding Reduction

Analytical Science Advances, Volume 6, Issue 2, December 2025.
ABSTRACT DNA probe design plays a critical role in biosensor‐based disease diagnostics, gene expression analysis and environmental monitoring. Traditional probe designs primarily target lower‐copy genetic sequences, often leading to low detection sensitivity due to limited hybridization events.
Younghwan Kim, Swomitra Kumar Mohanty
wiley   +1 more source