Results 211 to 220 of about 23,719,178 (251)

SMCHD1 Is Dispensable for Repeat-Induced FMR1 Hypermethylation in Fragile X Pluripotent Stem Cells. [PDF]

Int J Mol Sci
Aviel U, Kababw-Florentin A, Abu Diab M, Drier Y, Epsztejn-Litman S, Eiges R.   +5 more
europepmc   +1 more source

Targeting the HSPA8‐CMA‐ATP6V1A Axis Triggers Lysosomal Hyperacidification and Catastrophic Vacuolation in Prostate Cancer

Advanced Science, Volume 13, Issue 51, 14 September 2026.
Our experimental evidence supports a model in which ALO targets the HSPA8‐CMA‐ATP6V1A axis to induce lysosomal hyperacidification and initiate osmotic and lipidomic stress. These changes are associated with LMP and loss of lysosomal integrity in prostate cancer cells.
Bingzheng An, Ze Gao, Shuo Chen, Liwei Meng, Chen Zhang, Kefan Song, Haochen Cui, Lei Yan, Zhiqing Fang   +8 more
wiley   +1 more source

Mismatch-Tuned Plasmonic Nanogap Networks on Block Copolymers for Ultrasensitive Nucleic Acid Quantification. [PDF]

ACS Nanosci Au
Zhang Y, Du Y, Spillmann M, Akagi K, Tang J, Ramakrishna SN, Qiu G, Wang J.   +7 more
europepmc   +1 more source

Natural Variation of COLD and CATECHINS REGULATOR 1 Coordinately Fine‐Tunes Cold Tolerance and Tea Quality in Tea Plants

Advanced Science, Volume 13, Issue 52, 18 September 2026.
Multi‐trait genome‐wide association mapping identifies a central hub regulator, COLD AND CATECHINS REGULATOR 1 (CCR1), and its excellent natural allele variation, coordinately enhancing cold tolerance and promoting catechins biosyntheis. CsCCR1 interacts with CsCBF1/3 and is transcriptionally activated by CsLUX and CsKUA1 to promote catechins ...
Yanli Wang, Wei Tong, Qiong Wu, Didi Wu, Yanrui Zhang, Qijuan Gao, Fangdong Li, Zhaoliang Zhang, Wenjie Wang, Chuankui Song, Enhua Xia   +10 more
wiley   +1 more source

Rap1-mediated steric hindrance protects telomeres from MRX sensing. [PDF]

Nat Struct Mol Biol
Mattarocci S, Reginato G, Cannavo E, Roisné-Hamelin F, Gnügge R, Deshayes A, Pobiega S, Alibert O, Morin V, Ropars V, Mehringer J, Geli V, Cuniasse P, Charbonnier JB, Symington LS, Cejka P, Marcand S.   +16 more
europepmc   +1 more source

Biodegradable Acoustic Targeting for Ultrasound‐Supported Gene Therapy (BATUS) in Glioblastoma

Advanced Science, Volume 13, Issue 53, 24 September 2026.
ABSTRACT Glioblastoma (GBM) remains one of the most challenging brain malignancies due to the restrictive nature of the blood–brain barrier (BBB), which severely limits effective drug and gene delivery. To overcome this, we introduce Biodegradable Acoustic Targeting for Ultrasound‐Supported Gene Therapy (BATUS), a modular platform that enables safe ...
Gulsah Erel‐Akbaba, Jinyoung Park, Achal Duhoon, Cao Thuy Giang Nguyen, Nitu Bhaskar, Sumanta Kumar Karan, Hasan Akbaba, Parbeen Singh, Thi Bao Tram Tran, Yuhui Zhu, Zhiming Li, I'jaaz Muhammad, Xiaojun Zhang, Hoang Quan Truong, A. Daniel Davidar, Elizabeth Schmitzer, Vikas N. Vattipally, Angelica F. Lopez, Patrick Kramer, Victor M. Quiroz, Ben Bykov, Claire Hao, Amir Manbachi, Nicholas Theodore, Joshua C. Doloff, Thanh D. Nguyen   +25 more
wiley   +1 more source

Generation of Nasal Cell‐Derived Human Alveolar Organoids and Organoid‐Macrophage Assembloids for in Vitro Lung Modeling

Advanced Science, Volume 13, Issue 53, 24 September 2026.
This study demonstrates the generation of human alveolar organoids from nasal cells, which, when co‐cultured with monocyte‐derived macrophages, promotes maturation of both components and forms alveolar assembloids resembling native alveoli. These alveolar organoids and assembloids offer accessible, physiologically relevant in vitro systems for ...
Man Chun Chiu, Shuxin Zhang, Cun Li, Yifei Yu, Zhixin Wan, Jingjing Huang, Wei Xue, Ying Zhou, Xiaoxin Zhu, Qiaoshuai Lan, Jiali Wu, Zijun Zhao, Yuhong Liu, Xinjie Meng, Lin Huang, Hin Chu, Honglin Chen, Kelvin Kai‐Wang To, Kwok Yung Yuen, Jie Zhou   +19 more
wiley   +1 more source

Ascertainment Bias in Cattle SNP Arrays and Implications for Multibreed Genomic Predictions. [PDF]

Anim Genet
Warburton CL, Hayes BJ.
europepmc   +1 more source

Mapping Meiotic Recombination DNA Double‐Strand Breaks (DSBs) Hotspots —Methodological Advances and Challenges

Advanced Genetics, Volume 7, Issue 3, September 2026.
ABSTRACT Programmed DNA double‐strand breaks (DSBs) initiate meiotic recombination at discrete genomic hotspots, and their precise mapping is crucial for understanding the molecular regulation of genome stability and evolution. A variety of genome‐wide methods have been developed, each leveraging different biochemical principles — from direct capture ...
Jianqiang Bao
wiley   +1 more source

Development and validation of a quantitative pcr array assay for the detection of viral sequences in breast cancer. [PDF]

J Genet Eng Biotechnol
Del Carmen Trujillo-Murillo K, Lugo-Trampe A, Rodríguez-Sánchez IP, Martínez-Fierro ML, Cordero-Chaclan C, Tafurt-Cardona Y, Pérez PM, de Jesús Joo-Domínguez A, De la Cruz-Calderón R, Espinoza-Ruiz M, Chang-Rueda C, Lee-Faviel FC.   +11 more
europepmc   +1 more source