Results 61 to 70 of about 1,424,575 (357)

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

FEBS Open Bio, EarlyView.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr, Michael Fauler, Thomas Zimmer, Bettina Jungwirth, Hubert Schrezenmeier, David Alexander Christian Messerer   +5 more
wiley   +1 more source

Complex Approach to Species-Specific Detection of Cowpox Virus

Проблемы особо опасных инфекций, 2016
Objective of the study is to develop and validate the method for species-specific detection of cowpox virus (CPV). Materials and methods. Utilized were oligonucleotide primers and fluorescence-labeled probes for genus-specific detection of ...
R. A. Maksyutov
doaj   +1 more source

The cochaperone BAG3 promotes the stabilization of p53 under heat stress conditions

FEBS Open Bio, EarlyView.
Under heat stress, BAG3 translocates to the nucleus and forms a complex with Hsp70 and p53, thereby promoting p53 stabilization and enhancing its transcriptional activity. These findings suggest that BAG3 functions as a cochaperone that supports p53‐mediated stress responses in cooperation with Hsp70.
Ngoc Nguyen Thi Minh, Esther Lee, Soo‐A Kim   +2 more
wiley   +1 more source

Large Scale Explorative Oligonucleotide Probe Selection for Thousands of Genetic Groups on a Computing Grid: Application to Phylogenetic Probe Design Using a Curated Small Subunit Ribosomal RNA Gene Database

The Scientific World Journal, 2014
Phylogenetic Oligonucleotide Arrays (POAs) were recently adapted for studying the huge microbial communities in a flexible and easy-to-use way. POA coupled with the use of explorative probes to detect the unknown part is now one of the most powerful ...
Faouzi Jaziri, Eric Peyretaillade, Mohieddine Missaoui, Nicolas Parisot, Sébastien Cipière, Jérémie Denonfoux, Antoine Mahul, Pierre Peyret, David R. C. Hill   +8 more
doaj   +1 more source

Structural and functional characterization of chitinase from carnivorous plant Drosera adelae

FEBS Open Bio, EarlyView.
A class I chitinase from the carnivorous plant Drosera adelae was expressed and purified using a yeast system, revealing high enzymatic activity. Structural analyses of the catalytic and chitin‐binding domains identified key tyrosine residues involved in substrate binding, offering insights into the enzyme's adaptation for insect digestion.
Kazunari Yoneda, Yuki Naruse, Yusaku Suizu, Tomohiro Araki, Yoshikazu Hoshi, Haruhiko Sakuraba, Junji Hayashi, Toshihisa Ohshima   +7 more
wiley   +1 more source

The application of species specific DNA-targeted probes and fluorescently tagged lectin to differentiate several species of Pseudo-nitzschia (Bacillophyceae) in Chinhae Bay, Korea

Scientia Marina, 2001
We applied molecular methods using a DNA probe and fluorescently tagged lectins to discriminate toxic Pseudo-nitzschia multiseries from the Chinhae Bay for a Korean harmfulalgae monitoring program. From the binding activity of lectins, P. multistriata, P.
Eun Seob Cho, Jong Gyu Park, Bong Cheol Oh, Yong Chul Cho   +3 more
doaj   +1 more source

probeBase—an online resource for rRNA-targeted oligonucleotide probes: new features 2007

Nucleic Acids Res., 2006
probeBase is a curated database of annotated rRNA-targeted oligonucleotide probes and supporting information. Rapid access to probe, microarray and reference data is achieved by powerful search tools and via different lists that are based on selected ...
A. Loy, F. Maixner, M. Wagner, M. Horn
semanticscholar   +1 more source

Durable B‐Cell Impairment While Sparing IgA B Cells After Ocrelizumab Therapy in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Ocrelizumab (OCR), a humanized anti‐CD20 monoclonal antibody, is highly efficient in relapsing–remitting multiple sclerosis (RR‐MS). We assessed early cellular B‐cell profiles in patients prior to OCR treatment, on OCR treatment, and after 15 months of therapy discontinuation.
Alexandra Garcia, Stephane Rodriguez, Emilie Dugast, Christine Lebrun‐Frenay, Eric Thouvenot, Jérôme de Sèze, Emmanuelle Le Page, Sandra Vukusic, Inès Doghri, Eric Berger, Olivier Casez, Pierre Labauge, Aurélie Ruet, Catarina Raposo, Fabienne Le Frère, Arnaud B. Nicot, Sandrine Wiertlewski, Pierre‐Antoine Gourraud, Laure Michel, Laureline Berthelot, David‐Axel Laplaud   +20 more
wiley   +1 more source

Spotted cotton oligonucleotide microarrays for gene expression analysis

BMC Genomics, 2007
Background Microarrays offer a powerful tool for diverse applications plant biology and crop improvement. Recently, two comprehensive assemblies of cotton ESTs were constructed based on three Gossypium species.
Nettleton Dan, Gingle Alan R, Lee Jinsuk J, Swanson Jordan M, Rapp Ryan A, Hovav Ran, Woodward Andrew W, Cheung Foo, Flagel Lex E, Udall Joshua A, Town Christopher D, Chen Z Jeffrey, Wendel Jonathan F   +12 more
doaj   +1 more source

Using amino-labeled nucleotide probes for simultaneous single molecule RNA-DNA FISH. [PDF]

PLoS ONE, 2014
Using amino-labeled oligonucleotide probes, we established a simple, robust and low-noise method for simultaneous detection of RNA and DNA by fluorescence in situ hybridization, a highly useful tool to study the large pool of long non-coding RNAs being ...
Reelina Basu, Lan-Tian Lai, Zhenyu Meng, Jun Wu, Fangwei Shao, Li-Feng Zhang   +5 more
doaj   +1 more source