Results 81 to 90 of about 1,424,575 (357)

Development of an oligonucleotide dye solution facilitates high throughput and cost-efficient chromosome identification in peanut

Plant Methods, 2019
Background Development of oligonucleotide probes facilitates chromosome identification via fluorescence in situ hybridization (FISH) in many organisms.
Pei Du, Caihong Cui, Hua Liu, Liuyang Fu, Lina Li, Xiaodong Dai, Li Qin, Siyu Wang, Suoyi Han, Jing Xu, Bing Liu, Bingyan Huang, Fengshou Tang, Wenzhao Dong, Zengjun Qi, Xinyou Zhang   +15 more
doaj   +1 more source

Cholesterol in mRNA‐Lipid Nanoparticles can be Replaced with the Synthetic Mycobacterial Monomycoloyl Glycerol Analogue MMG‐1

Advanced Functional Materials, EarlyView.
This study demonstrates that cholesterol in messenger RNA‐lipid nanoparticles (mRNA‐LNPs) can be completely replaced with an immunopotentiating lipid, i.e., a synthetic analogue of the C‐type lectin receptor agonist monomycoloyl glycerol (MMG‐1), without compromising physicochemical properties, in vivo transfection efficiency, and immunogenicity of the
Abhijeet G. Lokras, Saahil S. Baghel, Rune F. Jensen, Aneesh Thakur, Henrik Franzyk, Oskar Thofte, Marco Herrera‐Barrera, Madeleine Landry, Melike Ongun, Ahmad Tami, Marlene P. Thanthrige, Eva Callens, Corinne Beinat, Thomas Rades, Søren R. Paludan, Kristian Riesbeck, Ida Rosenkrands, Dennis Christensen, Gabriel K. Pedersen, Camilla Foged   +19 more
wiley   +1 more source

Molecular probes for the identification of avian Haemoproteus and Leucocytozoon parasites in tissue sections by chromogenic in situ hybridization

Parasites & Vectors, 2019
Background Avian haemosporidian parasites can cause severe disease in their hosts due to excessive exo-erythrocytic merogony and anaemia caused by blood stages.
Tanja Himmel, Josef Harl, Anna Kübber-Heiss, Cornelia Konicek, Nuhacet Fernández, Carles Juan-Sallés, Mikas Ilgūnas, Gediminas Valkiūnas, Herbert Weissenböck   +8 more
doaj   +1 more source

Molecular Probe Data Base: a database on synthetic oligonucleotides

Nucleic Acids Research, 1992
The Molecular Probe Data Base (MPDB) was designed to collect and make information on synthetic oligonucleotides available on-line. This paper briefly describes its purpose, contents and structure, forms and mode of data distribution. Particular emphasis is given to recent data extension and system enhancements that have been carried out in order to ...
Paolo Romano, Ottavia Aresu, Barbara Parodi, Assunta Manniello, Giuseppina Campi, Giovanna Angelini, Massimo Romani, Beatrice Lannotta, Gabriella Rondanina, Tiziana Ruzzon, Leonardo Santi   +10 more
openaire   +7 more sources

Metal Nanoclusters for Cancer Imaging and Treatment

Advanced Functional Materials, EarlyView.
This review aims to provide a comprehensive summary and discussion of the core–shell design capabilities of metal nanoclusters (NCs) at the atomic level for cancer imaging and treatment. It offers essential insights into the design principles of metal NCs while also encouraging the exploration of other nanomaterials and their potential theranostic ...
Haiguang Zhu, Ziping Wang, Qiaofeng Yao, Ping Zhang, Jianping Xie, Xun Yuan   +5 more
wiley   +1 more source

Reconfigurable Nucleic Acid Nanoparticles with Therapeutic RNAi Responses to Intracellular Disease Markers

Advanced Functional Materials, EarlyView.
Many known diseases arise from dysregulated gene expression, and differentially expressed genes can serve as biomarkers to distinguish diseased cells from healthy tissues. In this study, reconfigurable nucleic acid nanoparticles (recNANPs) are introduced that can detect overexpressed cancer biomarkers and subsequently release RNAi inducers to silence ...
Yelixza I. Avila, Anh Ha, Morgan R. Chandler, Nathalia Leal Santos, Taejin Kim, Hannah S. Newton, Marina A. Dobrovolskaia, Kirill A. Afonin   +7 more
wiley   +1 more source

Nonradioactive method to detect native single-stranded G-tails on yeast telomeres using a modified Southern blot protocol

BioTechniques, 2011
Because of their low abundance and short length, telomeric single-stranded extensions have not traditionally been assessed by Southern blot analysis.
Lina M. Ortega, Christoph J. Hengartner, Leticia R. Vega   +2 more
doaj   +1 more source

Microbubble‐Controlled Delivery of Biofilm‐Targeting Nanoparticles to Treat MRSA Infection

Advanced Functional Materials, EarlyView.
Here, an effective strategy using microbubble (MB)‐controlled delivery of biofilm‐targeting nanoparticles (BTNs) for removal and therapy of methicillin‐resistant Staphylococcus aureus (MRSA) biofilm infections is introduced. In vivo delivery of MB with BTN is demonstrated to silence key bacterial genes involved in biofilm formation (icaA), bacterial ...
Ju Yeon Chung, Yujin Ahn, Joo Hun Lee, Seungju Yang, Seung Cheol Lee, Hyunjoon Kong, Hyun Jung Chung   +6 more
wiley   +1 more source

Fluorogenic PNA probes

Beilstein Journal of Organic Chemistry, 2018
Fluorogenic oligonucleotide probes that can produce a change in fluorescence signal upon binding to specific biomolecular targets, including nucleic acids as well as non-nucleic acid targets, such as proteins and small molecules, have applications in ...
Tirayut Vilaivan
doaj   +1 more source

Steady-State Fluorescence and Lifetime Emission Study of pH-Sensitive Probes Based on i-motif Forming Oligonucleotides Single and Double Labeled with Pyrene

Chemosensors, 2015
Cytosine-rich nucleic acids undergo pH-stimulated structural transitions leading to formation of an i-motif architecture at an acidic pH. Thus, i-motifs are good foundation for designing simple pH-sensitive fluorescent probes. We report here steady-state
Anna Dembska, Patrycja Rzepecka, Bernard Juskowiak   +2 more
doaj   +1 more source