Results 161 to 170 of about 119,501 (270)

Antisense Oligonucleotides [PDF]

, 2020
openaire   +1 more source

Gene therapy for epilepsy: An emerging, promising approach for a serious neurological disorder

Journal of Internal Medicine, EarlyView.
Abstract Gene therapy is emerging as a groundbreaking strategy for treating epilepsy, offering new hope to patients who do not respond to conventional medications. Despite advancements in anti‐seizure treatments, nearly 30%–40% of individuals with epilepsy continue to experience uncontrolled seizures, highlighting the urgent need for more effective and
Marco Ledri, Merab Kokaia
wiley   +1 more source

A pothole-filling strategy for selective targeting of rCUG-repeats associated with myotonic dystrophy type 1. [PDF]

Proc Natl Acad Sci U S A
Perera JDR, Thadke SA, Thrikawala SW, Dhami I, Hridya VM, Mukherjee A, Paul A, Wilson WD, Tan KWR, Chan NZW, Phan AT, Ly DH.   +11 more
europepmc   +1 more source

The FsrA‐Mediated Iron‐Sparing Response Regulates the Biosynthesis of the Epipeptide EPE in Bacillus subtilis

Molecular Microbiology, EarlyView.
Under iron‐limited conditions, FsrA base‐pairs with the intergenic region between epeX and epeE, enhancing epeE translation and triggering EPE production. Toxin‐mediated cell lysis releases nutrients, including iron, which can be taken up by surviving cells.
Sarah Miercke, Rabea Ghandour, Kai Papenfort, Thorsten Mascher   +3 more
wiley   +1 more source

LINC02081 as an oncogene promotes cell proliferation and G2/M cycle through p53 signaling pathway in lung adenocarcinoma. [PDF]

Transl Cancer Res
Zeng L, Wen H, Jiao T, Jiao T, Zhang Q, Han M, Chen Y, Yang S.   +7 more
europepmc   +1 more source

Cycloalkane Incorporation Into the 2',4'-Bridge of Locked Nucleic Acid: Enhancing Nuclease Stability, Reducing Phosphorothioate Modifications, and Lowering Hepatotoxicity in Antisense Oligonucleotides. [PDF]

JACS Au
Yamaguchi T, Komine H, Sugiura T, Kumagai R, Yoshida T, Sasaki K, Nakayama T, Kamada H, Inoue T, Obika S.   +9 more
europepmc   +1 more source

EBSn, a Robust Synthetic Reporter for Monitoring Ethylene Responses in Plants

Plant Biotechnology Journal, EarlyView.
ABSTRACT Ethylene is a gaseous plant hormone that controls a wide array of physiologically relevant processes, including plant responses to biotic and abiotic stress, and induces ripening in climacteric fruits. To monitor ethylene in plants, analytical methods, phenotypic assays, gene expression analysis and transcriptional or translational reporters ...
Josefina‐Patricia Fernandez‐Moreno, Mario Fenech, Anna E. Yaschenko, Chengsong Zhao, Matthew Neubauer, Hannah N. Davis, Alex J. Marchi, Raine Concannon, Alexandra Keren‐Keiserman, Moshe Reuveni, Victor Levitsky, Dmitry Oshchepkov, Vladislav Dolgikh, Alexander Goldshmidt, José T. Ascencio‐Ibáñez, Elena Zemlyanskaya, Jose M. Alonso, Anna N. Stepanova   +17 more
wiley   +1 more source

Systemic distribution of tricyclo-DNA antisense oligonucleotide following intratracheal instillation in the mouse. [PDF]

NAR Mol Med
Laurent J, Deramaudt TB, Cloix R, Robin V, Beley C, Garcia L, Bonay M.   +6 more
europepmc   +1 more source

Design of antisense oligonucleotides

Folia Pharmacologica Japonica, 2016
Satoshi, Obika, Yuuya, Kasahara
openaire   +3 more sources

The Jasmonate‐Responsive SmMPK3–SmWRKY33 Module Positively Regulates Tanshinone Biosynthesis in Salvia miltiorrhiza

Plant Biotechnology Journal, EarlyView.
ABSTRACT Tanshinones, the major bioactive diterpenes in Salvia miltiorrhiza Bunge, are widely used to treat cardiovascular and cerebrovascular diseases. While jasmonates (JAs) are known to modulate tanshinones accumulation, the molecular link between JA signalling and tanshinone biosynthesis remains unclear.
Renjun Qu, Shiwei Wang, Xinxin Wang, Jiaming Peng, Juan Guo, Guanghong Cui, Tong Chen, Meilan Chen, Shuangshuang Zhao, Ye Shen   +9 more
wiley   +1 more source