Antisense Oligonucleotides Targeting Angiogenic Factors as Potential Cancer Therapeutics [PDF]
Molecular Therapy: Nucleic Acids, 2019 Cancer is one of the leading causes of death worldwide, and conventional cancer therapies such as surgery, chemotherapy, and radiotherapy do not address the underlying molecular pathologies, leading to inadequate treatment and tumor recurrence ...
Bao T. Le +5 more
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Antisense oligonucleotides for the arterial hypertension mechanisms study and therapy [PDF]
Вавиловский журнал генетики и селекции, 2018 Arterial hypertension is one of the most common chronic diseases in adults all over the world. This pathology can not only reduce patients’ life quality, but can also be accompanied by a number of complications.
L. O. Klimov +4 more
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Targeting TGFβ Signaling to Address Fibrosis Using Antisense Oligonucleotides [PDF]
Biomedicines, 2018 Fibrosis results from the excessive accumulation of extracellular matrix in chronically injured tissue. The fibrotic process is governed by crosstalk between many signaling pathways.
James T. March +6 more
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Meeting report: antisense oligonucleotides. [PDF]
Haematologica, 1994 The use of antisense oligonucleotides as a therapeutic tool in modulating gene expression represents a newly established strategy for treating diseases. Such oligomers may be designed to complement a region of a specific gene or messenger RNA. Using this approach, oligonucleotides can serve as a potential block of transcription or translation through ...
G, Martinelli, S, Ferrari
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Antisense Oligonucleotides: Concepts and Pharmaceutical Applications [PDF]
Borneo Journal of Pharmacy, 2023 Antisense oligonucleotides are drugs whose mechanism is based on binding to RNA target sequences. For this purpose, they modify the protein expression through steric hindrance and exon omission.
Ariana Araya +5 more
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Light-controlled cell-free protein synthesis using phosphorothioate-caged antisense oligonucleotides [PDF]
, 2022 Cell-free expression of a gene to protein has become a vital tool applied in DNA nanodevices and synthetic cells. Antisense oligonucleotides are often used to induce gene knockdown; however, they have been underexplored for cell-free applications ...
Denis, Hartmann, Michael, Booth
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Characterization and Evaluation of NGF Antisense Oligonucleotides: Inhibition of NGF Synthesis in Transfected COS Cells [PDF]
, 1997 We present a system for the assessment of the inhibiting capacity of antisense oligonucleotides. The aim of this study was to identify an oligonucleotide that can inhibit chicken nerve growth factor (NGF) synthesis.
Sahlén, Anders, +5 more
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Advances in antisense oligonucleotide development for target identification, validation, and as novel therapeutics [PDF]
, 2008 Antisense oligonucleotides (As-ODNs) are single stranded, synthetically prepared strands of deoxynucleotide sequences, usually 18–21 nucleotides in length, complementary to the mRNA sequence of the target gene.
Alirio J. Melendez +3 more
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CD4 expression decrease by antisense oligonucleotides. Inhibition of rat T CD4+ cell reactivity [PDF]
, 2012 In previous studies, we have demonstrated the inhibition of CD4 expression in rat lymphocytes treated with phorbol myristate acetate (PMA) by antisense oligonucleotides (AS-ODNs) directed against the AUG start region of the cd4 gene.
Franch i Masferrer, Àngels +6 more
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Respiratory Research, 2007 Background The most common pathologic form of pulmonary fibrosis arises from excessive deposition of extracellular matrix proteins such as collagen. The 47 kDa heat shock protein 47 (HSP47) is a collagen-specific molecular chaperone that has been shown ...
Noguchi Takayuki +3 more
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