Results 31 to 40 of about 79,581 (296)

Sarm1 haploinsufficiency or low expression levels after antisense oligonucleotides delay programmed axon degeneration

Cell Reports, 2021
Summary: Activation of the pro-degenerative protein SARM1 after diverse physical and disease-relevant injuries causes programmed axon degeneration. Original studies indicate that substantially decreased SARM1 levels are required for neuroprotection ...
Stacey Anne Gould, Jonathan Gilley, Karen Ling, Paymaan Jafar-Nejad, Frank Rigo, Michael Coleman   +5 more
doaj   +1 more source

Consequences of Making the Inactive Active Through Changes in Antisense Oligonucleotide Chemistries

Frontiers in Genetics, 2019
Antisense oligonucleotides are short, single-stranded nucleic acid analogues that can interfere with pre-messenger RNA (pre-mRNA) processing and induce excision of a targeted exon from the mature transcript.
Khine Zaw, Khine Zaw, Kane Greer, Kane Greer, May Thandar Aung-Htut, May Thandar Aung-Htut, Chalermchai Mitrpant, Chalermchai Mitrpant, Rakesh N. Veedu, Rakesh N. Veedu, Sue Fletcher, Sue Fletcher, Steve D. Wilton, Steve D. Wilton   +13 more
doaj   +1 more source

Antisense-Induced Fas mRNA Degradation Produces Site-Specific Stable 3'-mRNA Fragment by Exonuclease Cleavage at the Complementary Sequence [PDF]

, 2004
Antisense-mediated degradation of target mRNA is achieved by the enzymatic action of nuclease RNase H. The enzyme recognizes hybrid RNA-DNA duplexes and hydrolyzes the RNA strand.
Dahlgren, Cecilia, Thonberg, H,, Cecilia Dahlgren, Dahlgren, C, Wahlestedt, C, Claes Wahlestedt, Wahlestedt, Claes, Håkan Thonberg, Thonberg, Håkan   +8 more
core   +1 more source

Taking control of gene expression with light-activated oligonucleotides

BioTechniques, 2007
The recent development of caged oligonucleotides that are efficiently activated by ultraviolet (UV) light creates opportunities for regulating gene expression with very high spatial and temporal resolution.
Ivan J. Dmochowski, XinJing Tang
doaj   +1 more source

Long-term administration of antisense oligonucleotides into the paraspinal muscles of mdx mice reduces kyphosis [PDF]

, 2008
The mdx mouse model of muscular dystrophy has a premature stop codon preventing production of dystrophin. This results in a progressive phenotype causing centronucleation of skeletal muscle fibers, muscle weakness and fibrosis and kyphosis.
Laws, Nicola, Fletcher, Susan, Cornford-Nairn, Renee A., Wilton, Stephen D., Hoey, Andrew J., Irwin, Nicole, Johnsen, Russell   +6 more
core   +1 more source

Anti-Niemann Pick C1 Single-Stranded Oligonucleotides with Locked Nucleic Acids Potently Reduce Ebola Virus Infection In Vitro

Molecular Therapy: Nucleic Acids, 2019
Ebola virus is the causative agent of Ebola virus disease, a severe, often fatal illness in humans. So far, there are no US Food and Drug Administration (FDA)-approved therapeutics directed against Ebola virus.
Anne Sadewasser, Erik Dietzel, Sven Michel, Michael Klüver, Markus Helfer, Tamara Thelemann, Richard Klar, Markus Eickmann, Stephan Becker, Frank Jaschinski   +9 more
doaj   +1 more source

The translation start codon region is sensitive to antisense PNA inhibition in Escherichia coli [PDF]

, 2003
Antisense peptide nucleic acids (PNA) can inhibit bacterial gene expression with gene and sequence specificity. Using attached carrier peptides that aid cell permeation, the antisense effects when targeting essential genes are sufficient to prevent ...
Aswasti, SK, Dryselius, R., Good, L., Good, L, Nielsen, P. E., Nielsen, PE, Rajarao, GK, Dryselius, R,, Kuttuva, Gunaratna R.,, Aswasti, S. K.   +9 more
core   +1 more source

Structural Diversity of Sense and Antisense RNA Hexanucleotide Repeats Associated with ALS and FTLD

Molecules, 2020
The hexanucleotide expansion GGGGCC located in C9orf72 gene represents the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar dementia (FTLD).
Tim Božič, Matja Zalar, Boris Rogelj, Janez Plavec, Primož Šket   +4 more
doaj   +1 more source

New treatments for myasthenia: a focus on antisense oligonucleotides [PDF]

, 2013
Corrado Angelini,1 Sara Martignago,2 Michela Bisciglia21IRCCS S Camillo, Via Alberoni, Venice, Italy; 2Department of Neurosciences, University of Padova, Via Giustiniani 5, 35128, Padova, ItalyAbstract: Autoimmune myasthenia gravis (MG) is a ...
Bisciglia M, Angelini C., Angelini C, Martignago S, Martignago S., Bisciglia M.   +5 more
core   +1 more source

A Kinetic Model Explains Why Shorter and Less Affine Enzyme-recruiting Oligonucleotides Can Be More Potent

Molecular Therapy: Nucleic Acids, 2014
Antisense oligonucleotides complementary to RNA targets promise generality and ease of drug design. The first systemically administered antisense drug was recently approved for treatment and others are in clinical development. Chemical modifications that
Lykke Pedersen, Peter H Hagedorn, Marie Wickström Lindholm, Morten Lindow   +3 more
doaj   +1 more source