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Antisense Oligonucleotides: Promise and Reality
Annual Review of Pharmacology and Toxicology, 2001Antisense oligonucleotides have been used for more than a decade to downregulate gene expression. Phosphodiester oligonucleotides are nuclease sensitive, and the more nuclease-resistant phosphorothioate oligonucleotides are now in common use in the laboratory and have entered clinical trials.
I, Lebedeva, C A, Stein
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History of Antisense Oligonucleotides
2003Biological science is a rapidly flowing experimental stream, at times encountering a dam that impedes further progress. At such a pomt, a single crack may induce a major breakthrough Discovery of the double helical structure of DNA in 1953 (1) caused such an event, with flooding of new information into the area now known as molecular biology.
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Antisense Oligonucleotides as Research Tools
2003The use of antisense oligonucleotides as both research tools and therapeutic molecules has emerged as a powerful alternative to small molecule inhibitors. Antisense oligonucleotides are short pieces of chemically modified DNA designed to hybridize to specific mRNA sequences present in the target gene.
J K, Taylor, S R, Cooper, N M, Dean
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Antisense oligonucleotide strategies in physiology
Molecular and Cellular Endocrinology, 1994Antisense oligonucleotides can inhibit gene expression in living cells by binding to complementary sequences of DNA, RNA or mRNA. The mechanisms include inhibition of RNA synthesis, RNA splicing, mRNA export, binding of initiation factors, assembly of ribosome subunits and of sliding of the ribosome along the mRNA coding sequence.
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Antisense technology: an overview and prospectus
Nature Reviews Drug Discovery, 2021Stanley T Crooke +2 more
exaly
Antisense oligonucleotide therapeutics
Expert Opinion on Investigational Drugs, 1999openaire +2 more sources
Immunomodulation by cytokine antisense oligonucleotides.
European cytokine network, 1995The cytokine network is involved in normal immune reaction and in the progression of several pathologies. Antisense (AS) oligonucleotides, which allow specific inhibition of expression of proteins, offer a new methodology to investigate this complex network. This review focuses on the use of AS to modulate cytokine expression.
Lefebvre d'Hellencourt, Christian +2 more
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