Results 231 to 240 of about 117,595 (294)

Morpholino-RNA duplex exhibits robust, sustained, and safe steric-block antisense activity by intracerebroventricular and intrathecal injection. [PDF]

Nat Commun
Yanagidaira M, Nagata T, Hasegawa J, Ishii T, Ebihara S, Nawa M, Yokota T.   +6 more
europepmc   +1 more source

Functional role of THRAP3 in modulating thyroid hormone-mediated gene networks in C2C12 myotubes. [PDF]

PLoS One
Fukushima T, Kuse S, Hasegawa Y, Fujioka T, Nikawa T, Masubuchi S, Sakakibara I.   +6 more
europepmc   +1 more source

Making sense of carbonic anhydrase function in zebrafish using antisense morpholinos. [PDF]

Mol Genet Genomics
Aspatwar A.
europepmc   +1 more source

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Antisense Oligonucleotides

Nephron Experimental Nephrology, 1998
Antisense technology was developed to inhibit gene expression by utilizing an oligonucleotide complementary to the mRNA which encodes the target gene. There are a few possible mechanisms for the inhibitory effects of antisense oligonucleotides. Among them, degradation of mRNA by RNase H is considered to be the major mechanism of action for antisense ...
N, Kashihara, Y, Maeshima, H, Makino
openaire   +2 more sources

Antisense-Oligonucleotide Therapy

New England Journal of Medicine, 1996
Many pharmacologic advances involve creating compounds that bind and disable proteins. Such compounds include propranolol, which blocks the β-adrenergic receptor; cimetidine, which blocks the H2 receptor; calcium-channel blockers; angiotensin-converting–enzyme inhibitors; and inhibitors of the H+/K+–ATPase pump.
F K, Askari, W M, McDonnell
openaire   +2 more sources

Antisense Oligonucleotide Drug Design

Current Pharmaceutical Design, 2004
Maneuvering single gene expression is not only an optimal way to study gene function but also an ambitious goal, which will lead to the treatment of a variety of human diseases whose main pathogenetic event is a genetic alteration. The recent efforts focusing on the genome project have led to array based, high throughput, gene expression analysis ...
SCHIAVONE, NICOLA, DONNINI, MARTINO, A. Nicolin, CAPACCIOLI, SERGIO   +3 more
openaire   +4 more sources

Antisense oligonucleotides.

Verhandelingen - Koninklijke Academie voor Geneeskunde van Belgie, 1997
Among the approaches which have been followed to convert a natural antisense phosphodiester oligonucleotide into a potential therapeutic agent, conjugation chemistry seems to be one of the most attractive. Indeed, natural phosphodiester oligonucleotide have the ideal properties (sequence specific hybridization, RNaseH activation, low or no toxicity ...
openaire   +3 more sources