Results 221 to 230 of about 143,834 (286)

Safety and toxicity assessment of antisense oligonucleotides in brain-relevant human cellular models. [PDF]

Mol Ther Nucleic Acids
Colar Zanjko L, Andrés-Santamaria R, Balogh A, van Roon-Mom WMC, Dinnyés A.   +4 more
europepmc   +1 more source

Understanding extracellular vesicles in antiaging

Periodontology 2000, EarlyView.
Abstract Background Aging is a multifactorial process marked by gradual cellular dysregulation, regulated by hallmarks, including genomic instability, mitochondrial dysregulation, and chronic inflammation. Extracellular vesicles (EVs), especially exosomes, have emerged as pivotal mediators of cell‐to‐cell communication with potential roles in both ...
Paras Ahmad, Nathan E. Estrin, Anton Sculean, Richard J. Miron   +3 more
wiley   +1 more source

WDR91, an endosomal maturation protein, promotes antisense oligonucleotide activity. [PDF]

Mol Ther Nucleic Acids
Chen S, Zheng T, Li D.
europepmc   +1 more source

Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights

The Journal of Physiology, EarlyView.
Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò, Miguel Martín‐Aragón Baudel, Charlotte E. R. Smith, Gonzalo Hernandez Hernandez, Donald M. Bers, Patrick M. Boyle, Dobromir Dobrev, Shanna Hamilton, Osama F. Harraz, Na Li, Thomas A. Longden, William E. Louch, Madeline Nieves‐Cintron, Matthew A. Nystoriak, Walter Lee Murfee, Przemysław B. Radwański, Swapnil K. Sonkusare, Manuel F. Navedo, Eleonora Grandi   +18 more
wiley   +1 more source

Use of conformationally locking antisense oligonucleotides for the targeted inhibition of precursor microRNAs. [PDF]

RSC Chem Biol
Westwood MN, Ma S, Saunders AJ, Howden SA, Keane SC.   +4 more
europepmc   +1 more source

Targeting ARF6-SUCNR1 Axis: Antisense Oligonucleotide Adjuvants for Neutrophil Immunometabolism. [PDF]

Int J Mol Sci
Wang Y, Chen Y.
europepmc   +1 more source

A 4'-Thioribouridine Modification Mimics 2'-O-Methoxyethyl in ASO-Like 20-Mers Targeting PTEN Knockdown. [PDF]

Chembiochem
Parkes JE, Benckendorff CMM, Malinowska AL, Roberts J, Huynh HL, Bose S, Cochard LM, Cheallaigh AN, Lovelock SL, Oliver PL, Miller GJ.   +10 more
europepmc   +1 more source

Differential human telomerase RNA knockdown by antisense oligonucleotides reveals the existence and potential function of a robust RNA domain. [PDF]

RNA
Lim NBY, Jeitany M, Dröge P, Lim KW, Phan AT.   +4 more
europepmc   +1 more source

Metabolic Dysfunction-Associated Steatotic Liver Disease and Emerging Oligonucleotide Therapies. [PDF]

Int J Biol Sci
Chen Q, Jiang J, Chiang Z, Li X, Zhang L, Wang L, Tse HF, Wang S, Lian Q.   +8 more
europepmc   +1 more source